Exosome: The “Off-the-Shelf” Cellular Nanocomponent as a Potential Pathogenic Agent, a Disease Biomarker, and Neurotherapeutics

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works

Exosomes: composition, biogenesis and function

Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,776 · see citing works

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Doyle, L. M., & Wang, M. Z. (2019) · Cells · doi:10.3390/cells8070727 · Cited by 3,271 · see citing works

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · cited 1× · see citing works

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843 · see citing works

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,768 · see citing works

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Asai, H., Ikezu, S., Tsunoda, S., Medalla, M., Luebke, J., Haydar, T., Wolozin, B., Butovsky, O., Kügler, S., & Ikezu, T. (2015) · Nature Neuroscience · doi:10.1038/nn.4132 · Cited by 1,591 · see citing works

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579 · see citing works

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Le‐Deygen, I. M., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky‐Papkov, M., Okolie, O., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,498 · see citing works

ExoCarta: A Web-Based Compendium of Exosomal Cargo

Keerthikumar, S., Chisanga, D., Ariyaratne, D., Saffar, H. A., Anand, S., Zhao, K., Samuel, M., Pathan, M., Jois, M., Chilamkurti, N., et al. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.09.019 · Cited by 1,447 · see citing works

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Lee, V. M.-Y., Balin, B. J., Otvos, L., & Trojanowski, J. Q. (1991) · Science · doi:10.1126/science.1899488 · Cited by 1,418 · see citing works

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356 · see citing works

Alzheimer’s disease β-amyloid peptides are released in association with exosomes

Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343 · see citing works

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246 · see citing works

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

Tian, T., Zhang, H.-X., He, C.-P., Fan, S., Zhu, Y.-L., Qi, C., Huang, N.-P., Xiao, Z.-D., Lu, Z.-H., Tannous, B. A., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.012 · Cited by 1,154 · see citing works

Frontotemporal dementia

Bang, J., Spina, S., & Miller, B. L. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00461-4 · Cited by 1,144 · see citing works

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115 · see citing works

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075 · see citing works

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., & Goedert, M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00504-7 · Cited by 1,026 · see citing works

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C. Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277061 · Cited by 985 · see citing works

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

Yang, T., Martin, P. B., Fogarty, B., Brown, A. H., Schurman, K., Phipps, R. J., Yin, V. P., Lockman, P. R., & Bai, S. (2015) · Pharmaceutical Research · doi:10.1007/s11095-014-1593-y · Cited by 980 · see citing works

Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes

Théry, C., Duban, L., Segura, É., Véron, P., Lantz, O. J., & Amigorena, S. (2002) · Nature Immunology · doi:10.1038/ni854 · Cited by 961 · see citing works

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

Fiandaca, M. S., Kapogiannis, D., Mapstone, M., Boxer, A., Eitan, E., Schwartz, J. B., Abner, E. L., Petersen, R. C., Federoff, H. J., Miller, B. L., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.008 · Cited by 959 · see citing works

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

Wu, M., Ouyang, Y., Wang, Z., Zhang, R., Huang, P., Chen, C., Li, H., Li, P., Quinn, D., Dao, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1709210114 · Cited by 958 · see citing works

A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

Brennan, K., Martin, K., Fitzgerald, S. P., O’Sullivan, J., Wu, Y., Blanco, A., Richardson, C., & Gee, M. M. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-57497-7 · Cited by 900 · see citing works

Exosomes are released by cultured cortical neurones

Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.003 · Cited by 896 · see citing works

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 894 · see citing works

Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein

Cabin, D. E., Shimazu, K., Murphy, D., Cole, N. B., Gottschalk, W., McIlwain, K. L., Orrison, B., Chen, A., Ellis, C. E., Paylor, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08797.2002 · Cited by 865 · see citing works

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal‐Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R., & McLean, P. J. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-42 · Cited by 852 · see citing works

WHO 2016 Classification of gliomas

Wesseling, P., & Capper, D. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12432 · Cited by 799 · see citing works

Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates

Lee, H.-J., Patel, S. S., & Lee, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0692-05.2005 · Cited by 798 · see citing works

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 773 · see citing works

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

Shao, H., Chung, J., Balaj, L., Charest, A., Bigner, D. D., Carter, B. S., Hochberg, F. H., Breakefield, X. O., Weissleder, R., & Lee, H. (2012) · Nature Medicine · doi:10.1038/nm.2994 · Cited by 757 · see citing works

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

Jia, G., Han, Y., An, Y., Ding, Y., He, C., Wang, X., & Tang, Q. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.029 · Cited by 753 · see citing works

Sorting it out: Regulation of exosome loading

Villarroya‐Beltri, C., Baixauli, F., Gutiérrez‐Vázquez, C., Sánchez‐Madrid, F., & Mittelbrunn, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.04.009 · Cited by 745 · see citing works

Engineering hybrid exosomes by membrane fusion with liposomes

Sato, Y. T., Umezaki, K., Sawada, S., Mukai, S.-A., Sasaki, Y., Harada, N., Shiku, H., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep21933 · Cited by 744 · see citing works

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Alvarez‐Erviti, L., Seow, Y., Schapira, A. H. V., Gardiner, C., Sargent, I. L., Wood, M. J. A., & Cooper, J. A. D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.029 · Cited by 741 · see citing works

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

Zhang, Y., Chopp, M., Meng, Y., Katakowski, M., Xin, H., Mahmood, A., & Xiong, Y. (2015) · Journal of neurosurgery · doi:10.3171/2014.11.jns14770 · Cited by 737 · see citing works

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

Stuffers, S., Wegner, C. S., Stenmark, H., & Brech, A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00920.x · Cited by 731 · see citing works

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 729 · see citing works

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 716 · see citing works

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

Shi, M., Liu, C., Cook, T. J., Bullock, K. M., Zhao, Y., Ginghina, C., Li, Y., Aro, P., Dator, R., He, C., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1314-y · Cited by 676 · see citing works

Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications

Patel, G. K., Khan, M. A., Zubair, H., Srivastava, S. K., Khushman, M. M., Singh, S., & Singh, A. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-41800-2 · Cited by 645 · see citing works

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

Kooijmans, S. A. A., Fliervoet, L. A. L., van der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., Henegouwen, P. M. P. V. B. E., Vader, P., & Schiffelers, R. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.009 · Cited by 629 · see citing works

Mesenchymal stem cell therapy: Two steps forward, one step back

Ankrum, J. A., & Karp, J. M. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.02.005 · Cited by 615 · see citing works

Exosomes and their roles in immune regulation and cancer

Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.009 · Cited by 608 · see citing works

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

Yang, J., Zhang, X., Chen, X., Wang, L., & Yang, G. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.04.010 · Cited by 592 · see citing works

Traumatic Brain Injury

Galgano, M. A., Toshkezi, G., Qiu, X., Russell, T., Chin, L. S., & Zhao, L. (2017) · Cell Transplantation · doi:10.1177/0963689717714102 · Cited by 588 · see citing works

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module

Yim, N., Ryu, S.-W., Choi, K., Lee, K. R., Lee, S., Choi, H., Kim, J., Shaker, M. R., Sun, W., Park, J.-H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12277 · Cited by 578 · see citing works

Microfluidic isolation and transcriptome analysis of serum microvesicles

Chen, C., Skog, J., Hsu, C.-H., Lessard, R. T., Balaj, L., Wurdinger, T., Carter, B. S., Breakefield, X. O., Toner, M., & Irimia, D. (2010) · Lab Chip · doi:10.1039/b916199f · Cited by 572 · see citing works

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

Riazifar, M., Mohammadi, M. R., Pone, E. J., Yeri, A., Lässer, C., Segaliny, A. I., McIntyre, L. L., Shelke, G. V., Hutchins, E., Hamamoto, A., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01004 · Cited by 551 · see citing works

Oligodendrocytes secrete exosomes containing major myelin and stress‐protective proteins: Trophic support for axons?

Krämer‐Albers, E., Bretz, N. P., Tenzer, S., Winterstein, C., Möbius, W., Berger, H., Nave, K., Schild, H., & Trotter, J. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200700522 · Cited by 548 · see citing works

Surface Functionalization of Exosomes Using Click Chemistry

Smyth, T., Petrova, K., Payton, N. M., Persaud, I., Redzic, J. S., Graner, M. W., Smith-Jones, P., & Anchordoquy, T. J. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500291r · Cited by 532 · see citing works

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Sardar Sinha, M., Ansell-Schultz, A., Civitelli, L., Hildesjö, C., Larsson, M., Lannfelt, L., Ingelsson, M., & Hallbeck, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1868-1 · Cited by 527 · see citing works

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

Guo, M., Wang, J., Zhao, Y., Feng, Y., Han, S., Dong, Q., Cui, M., & Tieu, K. (2020) · Brain · doi:10.1093/brain/awaa090 · Cited by 522 · see citing works

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

Nonaka, T., Masuda‐Suzukake, M., Arai, T., Hasegawa, Y., Akatsu, H., Obi, T., Yoshida, M., Murayama, S., Mann, D. M. A., Akiyama, H., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.007 · Cited by 520 · see citing works

Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice

Cooper, J. A. D., Wiklander, O. P. B., Nordin, J. Z., Al‐Shawi, R., Wood, M. J. A., Vithlani, M., Schapira, A. H. V., Simons, J. P., Andaloussi, S. E., & Alvarez‐Erviti, L. (2014) · Movement Disorders · doi:10.1002/mds.25978 · Cited by 509 · see citing works

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

Dinkins, M. B., Dasgupta, S., Wang, G., Zhu, G., & Bieberich, E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.012 · Cited by 494 · see citing works

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

Street, J. M., Barran, P. E., Mackay, C. L., Weidt, S. K., Balmforth, C., Walsh, T. S., Chalmers, R. T. A., Webb, D. J., & Dear, J. W. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-5 · Cited by 491 · see citing works

Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing

Didiot, M.-C., Hall, L. M., Coles, A. H., Haraszti, R. A., Godinho, B. M., Chase, K., Sapp, E., Ly, S., Alterman, J. F., Hassler, M. R., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.126 · Cited by 483 · see citing works

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b06939 · Cited by 482 · see citing works

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

Goetzl, E. J., Boxer, A. L., Schwartz, J. B., Abner, E. L., Petersen, R. C., Miller, B. L., & Kapogiannis, D. (2015) · Neurology · doi:10.1212/wnl.0000000000001702 · Cited by 466 · see citing works

Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

Thompson, A. G., Gray, E., Heman-Ackah, S. M., Mäger, I., Talbot, K., Andaloussi, S. E., Wood, M. J., & Turner, M. R. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.68 · Cited by 431 · see citing works

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

Lamichhane, T. N., Raiker, R. S., & Jay, S. M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00364 · Cited by 413 · see citing works

Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

Cheng, L., Doecke, J. D., Sharples, R. A., Villemagne, V. L., Fowler, C. J., Rembach, A., Martins, R. N., Rowe, C. C., Macaulay, S. L., Masters, C. L., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.127 · Cited by 409 · see citing works

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies

Jo, M., Lee, S., Jeon, Y., Kim, S., Kwon, Y., & Kim, H. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00513-7 · Cited by 405 · see citing works

Schwann cell‐derived exosomes enhance axonal regeneration in the peripheral nervous system

Lopez‐Verrilli, M. A., Picou, F., & Court, F. A. (2013) · Glia · doi:10.1002/glia.22558 · Cited by 404 · see citing works

Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease

Goetzl, E. J., Mustapić, M., Kapogiannis, D., Eitan, E., Lobach, I. V., Goetzl, L. M., Schwartz, J. B., & Miller, B. L. (2016) · The FASEB Journal · doi:10.1096/fj.201600756r · Cited by 397 · see citing works

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

Morel, L., Regan, M., Higashimori, H., Ng, S. K., Esau, C., Vidensky, S., Rothstein, J., & Yang, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410944 · Cited by 390 · see citing works

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

Cui, G., Wu, J., Mou, F., Xie, W., Wang, F., Wang, Q., Fang, J., Xu, Y., Dong, Y., Liu, J., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700600r · Cited by 387 · see citing works

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

Teng, F., & Fussenegger, M. (2020) · Advanced Science · doi:10.1002/advs.202003505 · Cited by 384 · see citing works

Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile

Winston, C. N., Goetzl, E. J., Akers, J. C., Carter, B. S., Rockenstein, E. M., Galasko, D. R., Masliah, E., & Rissman, R. A. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.04.001 · Cited by 379 · see citing works

Acceleration of α-Synuclein Aggregation by Exosomes

Grey, M., Dunning, C. J. R., Gaspar, R., Grey, C. E., Brundin, P., Sparr, E., & Linse, S. S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.585703 · Cited by 378 · see citing works

Concordance between the assessment of Aβ42, T‐tau, and P‐T181‐tau in peripheral blood neuronal‐derived exosomes and cerebrospinal fluid

Jia, L., Qiu, Q., Zhang, H., Chu, L., Du, Y., Zhang, J., Zhou, C., Liang, F., Shi, S., Wang, S., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.05.002 · Cited by 376 · see citing works

CD24 is a marker of exosomes secreted into urine and amniotic fluid

Keller, S., Rupp, C., Stoeck, A., Runz, S., Fogel, M., Lugert, S., Hager, H. D., Abdel‐Bakky, M. S., Gutwein, P., & Altevogt, P. (2007) · Kidney International · doi:10.1038/sj.ki.5002486 · Cited by 372 · see citing works

Exosome isolation from distinct biofluids using precipitation and column-based approaches

Martins, T. S., Catita, J. A. M., Rosa, I. M., Silva, O. A. B. D. C. E., & Henriques, A. G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198820 · Cited by 369 · see citing works

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers

Wu, Y., Deng, W., & Klinke, D. J. (2015) · The Analyst · doi:10.1039/c5an00688k · Cited by 368 · see citing works

The emerging role of exosomes in mental disorders

Saeedi, S., Israel, S. A., Nagy, C., & Turecki, G. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0459-9 · Cited by 367 · see citing works

Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism

Potolicchio, I., Carven, G. J., Xu, X., Stipp, C., Riese, R. J., Stern, L. J., & Santambrogio, L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2237 · Cited by 365 · see citing works

Exosome secretion is a key pathway for clearance of pathological TDP-43

Iguchi, Y., Eid, L., Parent, M., Soucy, G., Bareil, C., Riku, Y., Kawai, K., Takagi, S., Yoshida, M., Katsuno, M., et al. (2016) · Brain · doi:10.1093/brain/aww237 · Cited by 360 · see citing works

Engineered Exosomes as Vehicles for Biologically Active Proteins

Sterzenbach, U., Putz, U., Low, L., Silke, J., Tan, S., & Howitt, J. A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.030 · Cited by 341 · see citing works

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

Akers, J. C., Ramakrishnan, V., Kim, R., Skog, J., Nakano, I., Pingle, S. C., Kalinina, J., Hua, W., Kesari, S., Mao, Y. Q., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078115 · Cited by 335 · see citing works

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

Kalani, A., Tyagi, A. A., & Tyagi, N. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8544-1 · Cited by 333 · see citing works

Comparison of serum exosome isolation methods for microRNA profiling

Rekker, K., Saare, M., Roost, A. M., Kubo, A., Zarovni, N., Chiesi, A., Salumets, A., & Peters, M. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.10.020 · Cited by 327 · see citing works

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

Sung, B. H., von Lersner, A. K., Guerrero, J. F., Krystofiak, E., Inman, D. R., Pelletier, R., Zijlstra, A., Ponik, S. M., & Weaver, A. M. (2020) · Nature Communications · doi:10.1038/s41467-020-15747-2 · Cited by 313 · see citing works

Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

Chivet, M., Javalet, C., Laulagnier, K., Blot, B., Hemming, F. J., & Sadoul, R. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24722 · Cited by 307 · see citing works

Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages

Momen‐Heravi, F., Bala, S., Bukong, T. N., & Szabó, G. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.03.014 · Cited by 306 · see citing works

Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?

Gangoda, L., Boukouris, S., Liem, M., Kalra, H., & Mathivanan, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400234 · Cited by 301 · see citing works

Maximizing exosome colloidal stability following electroporation

Hood, J. L., Scott, M. J., & Wickline, S. A. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.12.001 · Cited by 297 · see citing works

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats

Huang, J., Yin, X.-M., Xu, Y., Xu, C., Lin, X., Ye, F., Cao, Y. B., & Lin, F. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5063 · Cited by 293 · see citing works

A Lumenal Domain-Dependent Pathway for Sorting to Intralumenal Vesicles of Multivesicular Endosomes Involved in Organelle Morphogenesis

Theos, A. C., Truschel, S. T., Tenza, D., Hurbain, I., Harper, D. C., Berson, J. F., Thomas, P. C., Raposo, G., & Marks, M. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.01.012 · Cited by 289 · see citing works

Exosomes in the Pathology of Neurodegenerative Diseases

Howitt, J. A., & Hill, A. F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.757955 · Cited by 287 · see citing works

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

Zhang, H., Wu, J. S., Wu, J., Fan, Q. W., Zhou, J., Wu, J., Liu, S., Zang, J., Ye, J., Xiao, M., et al. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0461-7 · Cited by 281 · see citing works

Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease

Ding, M., Shen, Y., Wang, P., Xie, Z., Xu, S., Zhu, Z., Wang, Y., Lyu, Y., Dewei, W., Xu, L., et al. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2641-5 · Cited by 279 · see citing works

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

Joshi, P., Turola, E., Ruiz, A., Bergami, A., Libera, D. D., Benussi, L., Giussani, P., Magnani, G., Comı, G., Legname, G., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.180 · Cited by 274 · see citing works

Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation

Fröhlich, D., Kuo, W. P., Frühbeis, C., Sun, J.-J., Zehendner, C. M., Luhmann, H. J., Pinto, S., Toedling, J., Trotter, J., & Krämer-Albers, E.-M. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0510 · Cited by 274 · see citing works

Regulation of heat shock protein 70 release in astrocytes: Role of signaling kinases

Taylor, A. R., Robinson, M., Gifondorwa, D. J., Tytell, M., & Milligan, C. E. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20559 · Cited by 261 · see citing works

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

Jarmalavičiūtė, A., Tunaitis, V., Pivoraitė, U., Venalis, A., & Pivoriūnas, A. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2014.07.013 · Cited by 260 · see citing works

Aptamer-Conjugated Extracellular Nanovesicles for Targeted Drug Delivery

Wan, Y., Wang, L., Zhu, C., Zheng, Q., Wang, G., Tong, J., Fang, Y., Xia, Y., Cheng, G., He, X., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-2880 · Cited by 260 · see citing works

The second brain and Parkinson’s disease

Lebouvier, T., Chaumette, T., Paillusson, S., Duyckaerts, C. J., Varannes, S. B. D., Neunlist, M., & Derkinderen, P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06873.x · Cited by 258 · see citing works

Exosomes regulate neurogenesis and circuit assembly

Sharma, P., Mesci, P., Carromeu, C., Mcclatchy, D., Schiapparelli, L., Yates, J., Muotri, A., & Cline, H. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1902513116 · Cited by 257 · see citing works

Molecules relevant for T cell‐target cell interaction are present in cytolytic granules of human T lymphocytes

Peters, P. J., Geuze, H. J., van der Donk, H., Slot, J. W., Griffith, J. M., Stam, N. J., Clevers, H. C., & Borst, J. G. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190819 · Cited by 251 · see citing works

Exosomal transfer of proteins and RNAs at synapses in the nervous system

Smalheiser, N. R. (2007) · Biology Direct · doi:10.1186/1745-6150-2-35 · Cited by 251 · see citing works

Blood neuro‐exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

Jia, L., Zhu, M., Kong, C., Pang, Y., Zhang, H., Qiu, Q., Wei, C., Tang, Y., Wang, Q., Li, Y., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12166 · Cited by 251 · see citing works

Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium

Dong, L., Zieren, R. C., Horie, K., Kim, C., Mallick, E. R., Jing, Y., Feng, M., Kuczler, M. D., Green, J. J., Amend, S. R., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12044 · Cited by 248 · see citing works

Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

Korkut, C., Li, Y., Koles, K., Brewer, C., Ashley, J., Yoshihara, M., & Budnik, V. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.013 · Cited by 242 · see citing works

CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

Hornung, S., Dutta, S., & Bitan, G. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00038 · Cited by 239 · see citing works

MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury

Yang, Y., Ye, Y., Su, X., He, J., Bai, W., & He, X. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00055 · Cited by 236 · see citing works

Diffuse type of senile plaques in the brains of Alzheimer-type dementia

Yamaguchi, H., Hirai, S., Morimatsu, M., Shoji, M., & Harigaya, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00687420 · Cited by 235 · see citing works

The Serum Exosome Derived MicroRNA-135a, -193b, and -384 Were Potential Alzheimer's Disease Biomarkers.

Yang, T., Liu, C. G., Gao, S. C., Zhang, Y., & Wang, P. C. (2018) · PubMed · doi:10.3967/bes2018.011 · Cited by 230 · see citing works

Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis

Gomes, C., Keller, S., Altevogt, P., & Costa, J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.024 · Cited by 228 · see citing works

Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke

Chen, K., Chen, C., Wallace, C. G., Yuen, C.-M., Kao, G., Chen, Y., Shao, P., Chen, Y., Chai, H., Lin, K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12902 · Cited by 226 · see citing works

Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

Ladiwala, A. R. A., Litt, J., Kane, R. S., Aucoin, D., Smith, S. O., Ranjan, S., Davis, J., Nostrand, W. E. V., & Tessier, P. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.329763 · Cited by 223 · see citing works

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease

Liu, C., Song, J., Zhang, Y., & Wang, P. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2484 · Cited by 221 · see citing works

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

Webb, R. L., Kaiser, E. E., Jurgielewicz, B. J., Spellicy, S. E., Scoville, S. L., Thompson, T. A., Swetenburg, R. L., Hess, D. C., West, F. D., & Stice, S. L. (2018) · Stroke · doi:10.1161/strokeaha.117.020353 · Cited by 219 · see citing works

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

Yang, Z., Xie, J., Zhu, J., Chen, K., Chiang, C., Wang, X., Wang, X., Kuang, T., Chen, F., Chen, Z., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.008 · Cited by 217 · see citing works

Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes

Wan, S., Zhang, L., Wang, S., Liu, Y., Wu, C. S., Cui, C., Sun, H. R., Shi, M., Jiang, Y. Y., Li, L., et al. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b00319 · Cited by 209 · see citing works

MicroRNA biomarkers of Parkinson’s disease in serum exosome-like microvesicles

Cao, X., Lu, J., Zhao, Z., Li, M.-C., Lu, T., An, X., & Xue, L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.045 · Cited by 207 · see citing works

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease

Shi, M., Kovac, A., Korff, A., Cook, T. J., Ginghina, C., Bullock, K. M., Yang, L., Stewart, T., Zheng, D., Aro, P., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.04.003 · Cited by 206 · see citing works

Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme

Ye, Z., Zhang, T., He, W., Jin, H., Liu, C., Yang, Z., & Ren, J. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18135 · Cited by 206 · see citing works

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients

Cha, D. J., Mengel, D., Mustapić, M., Liu, W., Selkoe, D. J., Kapogiannis, D., Galasko, D. R., Rissman, R. A., Bennett, D. A., & Walsh, D. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01208 · Cited by 200 · see citing works

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

Abels, E. R., Maas, S. L. N., Nieland, L., Wei, Z., Cheah, P. S., Tai, E., Kolsteeg, C.-J., Dusoswa, S. A., Ting, D. T., Hickman, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.036 · Cited by 199 · see citing works

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

von Bartheld, C. S., & Altick, A. L. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.003 · Cited by 197 · see citing works

Increasing vaccine potency through exosome antigen targeting

Hartman, Z. C., Wei, J., Glass, O. K., Guo, H., Lei, G., Yang, X.-Y., Osada, T., Hobeika, A., Delcayre, A., Le Pecq, J.-B., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.09.133 · Cited by 196 · see citing works

Exosome Display technology: Applications to the development of new diagnostics and therapeutics

Delcayre, A. X., Estellés, A., Sperinde, J. J., Roulon, T., PAZ, P. E., Aguilar, B. A., Villanueva, J. C., Khine, S., & Pecq, J. L. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.07.003 · Cited by 190 · see citing works

Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine

Wei, W., Ao, Q., Wang, X., Cao, Y., Liu, Y., Zheng, S. G., & Tian, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.590470 · Cited by 189 · see citing works

Microfluidic affinity separation chip for selective capture and release of label-free ovarian cancer exosomes

Hisey, C. L., Dorayappan, K. D. P., Cohn, D. E., Selvendiran, K., & Hansford, D. J. (2018) · Lab on a Chip · doi:10.1039/c8lc00834e · Cited by 182 · see citing works

Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation

Wang, J.-H., Forterre, A. V., Zhao, J., Frimannsson, D. O., Delcayre, A., Antes, T. J., Efron, B., Jeffrey, S. S., Pegram, M. D., & Matin, A. C. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0827 · Cited by 181 · see citing works

The Impact of Oncogenic EGFRvIII on the Proteome of Extracellular Vesicles Released from Glioblastoma Cells

Choi, D., Montermini, L., Kim, D., Meehan, B., Roth, F. P., & Rak, J. W. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000644 · Cited by 177 · see citing works

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

Zhao, Z., Chen, Z., Zhou, R., Zhang, X., Ye, Q., & Wang, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00438 · Cited by 177 · see citing works

MicroRNA Expression Levels Are Altered in the Cerebrospinal Fluid of Patients with Young-Onset Alzheimer’s Disease

McKeever, P. M., Schneider, R., Taghdiri, F., Weichert, A., Multani, N., Brown, R. A., Boxer, A. L., Karydas, A., Miller, B. L., Robertson, J., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1032-x · Cited by 175 · see citing works

Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy

Zhan, Q., Yi, K., Qi, H., Li, S., Li, X., Wang, Q., Wang, Y., Liu, C., Qiu, M., Yuan, X., et al. (2020) · Theranostics · doi:10.7150/thno.45028 · Cited by 174 · see citing works

BIN1 favors the spreading of Tau via extracellular vesicles

Crotti, A., Sait, H. R., McAvoy, K. M., Estrada, K., Ergun, A., Szak, S., Marsh, G., Jandreski, L., Peterson, M., Reynolds, T. L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45676-0 · Cited by 171 · see citing works

Application of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Stroke: Biodistribution and MicroRNA Study

Moon, G. J., Sung, J. H., Kim, D. H., Kim, E. H., Cho, Y. H., Son, J. P., Cha, J. M., & Bang, O. Y. (2019) · Translational Stroke Research · doi:10.1007/s12975-018-0668-1 · Cited by 166 · see citing works

Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery

Wang, M., Altınoglu, S., Takeda, Y. S., & Xu, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141860 · Cited by 164 · see citing works

Urine Exosomes

Street, J. M., Koritzinsky, E. H., Glispie, D. M., Star, R. A., & Yuen, P. S. T. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.07.003 · Cited by 162 · see citing works

A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker

Santangelo, A., Imbrucè, P., Gardenghi, B., Belli, L., Agushi, R., Tamanini, A., Munari, S., Bossi, A., Scambi, I., Benati, D., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2639-x · Cited by 160 · see citing works

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

Muraoka, S., Jedrychowski, M. P., Yanamandra, K., Ikezu, S., Gygi, S. P., & Ikezu, T. (2020) · Cells · doi:10.3390/cells9091959 · Cited by 157 · see citing works

Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

Feneberg, E., Steinacker, P., Lehnert, S., Schneider, A., Walther, P., Thal, D. R., Linsenmeier, M., Ludolph, A. C., & Otto, M. (2014) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2014.905606 · Cited by 156 · see citing works

Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells

Lucero, R., Zappulli, V., Sammarco, A., Murillo, O. D., Cheah, P.-S., Srinivasan, S., Tai, E. C., Ting, D. T., Wei, Z., Roth, M. E., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.073 · Cited by 155 · see citing works

Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel

Gill, J., Mustapić, M., Diaz-Arrastia, R. R., Lange, R. T., Gulyani, S., Diehl, T., Motamedi, V., Osier, N. D., Stern, R. A., & Kapogiannis, D. (2018) · Brain Injury · doi:10.1080/02699052.2018.1471738 · Cited by 152 · see citing works

Genome-Wide, Integrative Analysis Implicates Exosome-Derived MicroRNA Dysregulation in Schizophrenia

Du, Y., Yu, Y., Hu, Y., Li, X., Wei, Z., Pan, R., Li, X.-S., Zheng, G.-E., Qin, X., Liu, Q., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby191 · Cited by 152 · see citing works

Exosomes in Human Breast Milk Promote EMT

Qin, W., Tsukasaki, Y., Dasgupta, S., Mukhopadhyay, N. D., Ikebe, M., & Sauter, E. R. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0135 · Cited by 145 · see citing works

MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging

Machida, T., Tomofuji, T., Ekuni, D., Maruyama, T., Yoneda, T., Kawabata, Y., Mizuno, H., Miyai, H., Kunitomo, M., & Morita, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921294 · Cited by 144 · see citing works

Cerebrospinal fluid extracellular vesicle enrichment for protein biomarker discovery in neurological disease; multiple sclerosis

Welton, J. L., Loveless, S., Stone, T., von Ruhland, C., Robertson, N. P., & Clayton, A. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1369805 · Cited by 142 · see citing works

Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer’s Disease

Elia, C. A., Tamborini, M., Rasile, M., Desiato, G., Marchetti, S., Swuec, P., Mazzitelli, S., Clemente, F., Anselmo, A., Matteoli, M., et al. (2019) · Cells · doi:10.3390/cells8091059 · Cited by 142 · see citing works

The basis of clinicopathological heterogeneity in TDP-43 proteinopathy

Kawakami, I., Arai, T., & Hasegawa, M. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02077-x · Cited by 128 · see citing works

State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review

Donoso‐Quezada, J., Ayala‐Mar, S., & González‐Valdez, J. (2020) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1785385 · Cited by 127 · see citing works

The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes

Huang, K., Fang, C., Yi, K., Liu, X., Qi, H., Tan, Y., Zhou, J., Li, Y., Liu, M., Zhang, Y., et al. (2018) · Theranostics · doi:10.7150/thno.22952 · Cited by 126 · see citing works

Exosomes from Human Gingiva-Derived Mesenchymal Stem Cells Combined with Biodegradable Chitin Conduits Promote Rat Sciatic Nerve Regeneration

Rao, F., Zhang, D., Fang, T., Lu, C., Wang, B., Ding, X., Wei, S., Zhang, Y., Pi, W., Xu, H., et al. (2019) · Stem Cells International · doi:10.1155/2019/2546367 · Cited by 123 · see citing works

Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system

Trueta, C., & De‐Miguel, F. F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00319 · Cited by 122 · see citing works

The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks

Borroto‐Escuela, D. O., Agnati, L. F., Bechter, K., Jansson, A., Tarakanov, A. O., & Fuxé, K. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0183 · Cited by 121 · see citing works

Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation

Lässer, C., O’Neil, S., Shelke, G. V., Sihlbom, C., Hansson, S., Gho, Y. S., Lundbäck, B., & Lötvall, J. O. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0927-4 · Cited by 120 · see citing works

Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures

Cohn, W., Melnik, M., Huang, C., Teter, B., Chandra, S., Zhu, C., McIntire, L. B., John, V., Gylys, K. H., & Bilousova, T. V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.766082 · Cited by 120 · see citing works

Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex

Madison, M. N., Jones, P. H., & Okeoma, C. M. (2015) · Virology · doi:10.1016/j.virol.2015.03.040 · Cited by 116 · see citing works

Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes

Yagi, Y., Ohkubo, T., Kawaji, H., Machida, A., Miyata, H., Goda, S., Roy, S., Hayashizaki, Y., Suzuki, H., & Yokota, T. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.042 · Cited by 115 · see citing works

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways

Hallal, S. M., Mallawaaratchy, D. M., Wei, H., Ebrahimkhani, S., Stringer, B. W., Day, B. W., Boyd, A., Guillemin, G. J., Buckland, M. E., & Alexander, K. L. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1385-1 · Cited by 114 · see citing works

Highly efficient exosome purification from human plasma by tangential flow filtration based microfluidic chip

Han, Z., Peng, C., Yi, J., Zhang, D., Xiang, X., Peng, X., Su, B., Liu, B., Shen, Y., & Qiao, L. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.129563 · Cited by 114 · see citing works

Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance

Nasca, C., Dobbin, J., Bigio, B., Watson, K. T., de Angelis, P., Kautz, M. M., Cochran, A., Mathé, A. A., Kocsis, J. H., Lee, F. S., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0804-7 · Cited by 113 · see citing works

Exosomal neurofilament light

Guedes, V. A., Kenney, K., Shahim, P., Qu, B., Lai, C., Devoto, C., Walker, W. C., Nolen, T. L., Diaz-Arrastia, R. R., Gill, J., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009577 · Cited by 112 · see citing works

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity

Winston, C. N., Romero, H. K., Ellisman, M., Nauss, S. N., Julovich, D. A., Conger, T., Hall, J. R., Campana, W. M., O’Bryant, S. E., Nievergelt, C. M., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01005 · Cited by 111 · see citing works

Combination of Size-Exclusion Chromatography and Ultracentrifugation Improves the Proteomic Profiling of Plasma-Derived Small Extracellular Vesicles

Wei, R., Zhao, L., Kong, G., Liu, X., Zhu, S., Zhang, S., & Min, L. (2020) · Biological Procedures Online · doi:10.1186/s12575-020-00125-5 · Cited by 110 · see citing works

Apolipoprotein E4 genotype compromises brain exosome production

Peng, K. Y., Pérez-González, R., Alldred, M. J., Goulbourne, C. N., Morales-Corraliza, J., Saito, M., Saito, M., Ginsberg, S. D., Mathews, P. M., & Levy, E. (2019) · Brain · doi:10.1093/brain/awy289 · Cited by 109 · see citing works

BDNF and pro-BDNF in serum and exosomes in major depression: Evolution after antidepressant treatment

Gellé, T., Samey, R. A., Plansont, B., Bessette, B., Jauberteau, M., Lalloué, F., & Girard, M. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110229 · Cited by 109 · see citing works

SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status

Sheng, Y., Chattopadhyay, M., Whitelegge, J. P., & Valentine, J. S. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611212220010 · Cited by 108 · see citing works

Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage

Luo, Q., Xian, P., Wang, T., Wu, S., Sun, T., Wang, W., Wang, B., Yang, H., Yang, Y., Wang, H., et al. (2021) · Theranostics · doi:10.7150/thno.58632 · Cited by 104 · see citing works

Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype

Oushy, S. H., Hellwinkel, J. E., Wang, M. X., Nguyen, G. J., Gunaydin, D., Harland, T., Anchordoquy, T. J., & Graner, M. W. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0477 · Cited by 103 · see citing works

An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease

Banack, S. A., Dunlop, R. A., & Cox, P. A. (2020) · Open Biology · doi:10.1098/rsob.200116 · Cited by 103 · see citing works

Profiling of Serum Exosome MiRNA Reveals the Potential of a MiRNA Panel as Diagnostic Biomarker for Alzheimer’s Disease

Dong, Z., Gu, H., Guo, Q., Liang, S., Xue, J., Yao, F., Liu, X., Li, F., Liu, H., Sun, L., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02323-y · Cited by 103 · see citing works

A novel cell‐cell communication mechanism in the nervous system: exosomes

Zhang, G., & Yang, P. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24113 · Cited by 97 · see citing works

Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson's Disease

Zou, J., Guo, Y., Wei, L., Yu, F. F., Yu, B., & Xu, A. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00842-5 · Cited by 95 · see citing works

Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid

Otake, K., Kamiguchi, H., & Hirozane, Y. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0473-z · Cited by 94 · see citing works

Knockdown of TGF-β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells

Zhao, X., Wu, X., Qian, M., Song, Y., Wu, D. L., & Zhang, W. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.026 · Cited by 93 · see citing works

Isolation and Analysis of Plasma-Derived Exosomes in Patients With Glioma

Garcia, L. M. C., Peterson, T. E., Cepeda, M. A., Johnson, A. J., & Parney, I. F. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00651 · Cited by 92 · see citing works

Modulatory effects of oligodendrocytes on the conduction velocity of action potentials along axons in the alveus of the rat hippocampal CA1 region.

Yamazaki, Y., Hozumi, Y., Kaneko, K., Sugihara, T., Fujii, S., Goto, K., & Kato, H. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000070 · Cited by 91 · see citing works

Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

Gao, X., Zhang, Z., Mashimo, T., Shen, B., Nyagilo, J. O., Wang, H., Wang, Y., Liu, Z., Mulgaonkar, A., Hu, X.-L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.089 · Cited by 88 · see citing works

Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls

Denk, J., Oberhauser, F., Kornhuber, J., Wiltfang, J., Fassbender, K. C., Schroeter, M. L., Volk, A. E., Diehl‐Schmid, J., Prudlo, J., Danek, A., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197329 · Cited by 87 · see citing works

MiR-17–92 Cluster-Enriched Exosomes Derived from Human Bone Marrow Mesenchymal Stromal Cells Improve Tissue and Functional Recovery in Rats after Traumatic Brain Injury

Zhang, Y., Zhang, Y., Chopp, M., Pang, H., Zhang, Z. G., Mahmood, A., & Xiong, Y. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2020.7575 · Cited by 87 · see citing works

Emerging concepts on the role of exosomes in lipid metabolic diseases

Record, M., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimie · doi:10.1016/j.biochi.2013.06.016 · Cited by 86 · see citing works

Targeting soluble proteins to exosomes using a ubiquitin tag

Cheng, Y., & Schorey, J. S. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25884 · Cited by 85 · see citing works

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Wang, S., Liu, Z., Ye, T., Mabrouk, O. S., Maltbie, T., Aasly, J. O., & West, A. B. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0492-y · Cited by 84 · see citing works

Comparison of the extraction and determination of serum exosome and miRNA in serum and the detection of miR-27a-3p in serum exosome of ALS patients

Xu, Q., Zhao, Y., Zhou, X., Luan, J. Y., Cui, Y., & Han, J. (2018) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2017.01091 · Cited by 83 · see citing works

Exosomal lncRNA‑ATB activates astrocytes that promote glioma cell invasion

Bian, E., Chen, E., Xu, Y., Yang, Z., Tang, F. R., Ma, C., Wang, H., & Zhao, B. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4644 · Cited by 81 · see citing works

Circulating exosomal microRNAs in bipolar disorder

Ceylan, D., Tüfekçi, K. U., Keskinoğlu, P., Genç, Ş., & Özerdem, A. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.10.038 · Cited by 81 · see citing works

Cloaked Exosomes: Biocompatible, Durable, and Degradable Encapsulation

Kumar, S., Michael, I. J., Park, J., Granick, S., & Cho, Y. (2018) · Small · doi:10.1002/smll.201802052 · Cited by 73 · see citing works

Surface Engineering of Extracellular Vesicles through Chemical and Biological Strategies

Richardson, J. J., & Ejima, H. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b00050 · Cited by 73 · see citing works

A direct extraction method for microRNAs from exosomes captured by immunoaffinity beads

Yoo, C. E., Kim, G., Kim, M.-S., Park, D., Kang, H. J., Lee, M., & Huh, N. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.09.008 · Cited by 71 · see citing works

Circulating Brain Injury Exosomal Proteins following Moderate-to-Severe Traumatic Brain Injury: Temporal Profile, Outcome Prediction and Therapy Implications

Mondello, S., Guedes, V. A., Lai, C., Czeiter, E., Amrein, K., Kobeissy, F. H., Mechref, Y. S., Jeromin, A., Mithani, S., Martin, C. A., et al. (2020) · Cells · doi:10.3390/cells9040977 · Cited by 71 · see citing works

Proteomic analysis of exosome-enriched fractions derived from cerebrospinal fluid of amyotrophic lateral sclerosis patients

Hayashi, N., Doi, H., Kurata, Y., Kagawa, H., Atobe, Y., Funakoshi, K., Tada, M., Katsumoto, A., Tanaka, K., Kunii, M., et al. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.10.010 · Cited by 70 · see citing works

Current strategies in tailoring methods for engineered exosomes and future avenues in biomedical applications

Mishra, A., Singh, P., Qayoom, I., Prasad, A., & Kumar, A. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01088c · Cited by 68 · see citing works

Low dose of extracellular vesicles identified that promote recovery after ischemic stroke

Otero‐Ortega, L., Laso-García, F., Frutos, M. C. G.-D., Diekhorst, L., Martínez-Arroyo, A., Alonso‐López, E., García‐Bermejo, L., Rodríguez‐Serrano, M., Arrúe-Gonzalo, M., Díez‐Tejedor, E., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01601-1 · Cited by 67 · see citing works

Exosomal TAR DNA-binding protein-43 and neurofilaments in plasma of amyotrophic lateral sclerosis patients: A longitudinal follow-up study

Chen, P.-C., Wu, D., Hu, C., Chen, H., Hsieh, Y., & Huang, C. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117070 · Cited by 67 · see citing works

Biophysical Characterization and Drug Delivery Potential of Exosomes from Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

Chopra, N., Arya, B., Jain, N., Yadav, P., Wajid, S., Singh, S. P., & Choudhury, S. (2019) · ACS Omega · doi:10.1021/acsomega.9b01180 · Cited by 63 · see citing works

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

Zhao, J., Zou, F.-L., Zhu, J.-F., Huang, C., Bu, F., Zhu, Z., & Yuan, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1025618 · Cited by 25 · see citing works

Small extracellular vesicles from HO-1-modified bone marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury after steatotic liver transplantation by suppressing ferroptosis via miR-214-3p

Zuo, H., Wang, Y., Yuan, M., Zheng, W., Tian, X., Pi, Y., Zhang, X., & Song, H. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110793 · Cited by 23 · see citing works

Characterization of Exosome-like Nanoparticles from Saffron Tepals and Their Immunostimulatory Activity

Fajardo, C. M., Jiménez, A. J. L., López‐López, S., Morote, L., Giménez, E. M., Diretto, G., guerra, M. J. M. M., Rubio‐Moraga, Á., Ahrazem, O., & Gómez‐Gómez, L. (2025) · Biology · doi:10.3390/biology14020215 · Cited by 19 · see citing works

Application of exosomes as nanocarriers in cancer therapy

Hu, J., Zhu, J., Chai, J., Zhao, Y., Luan, J., & Wang, Y. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01991h · Cited by 17 · see citing works

EphA4 Targeting Peptide-Conjugated Extracellular Vesicles Rejuvenates Adult Neural Stem Cells and Exerts Therapeutic Benefits in Aging Rats

Ghosh, S., Roy, R., Mukherjee, N., Ghosh, S., Jash, M., Jana, A., & Ghosh, S. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00331 · Cited by 6 · see citing works

Enhanced endometrial receptivity via epigallocatechin gallate (EGCG)-loaded menstrual blood-derived exosomes

Rasool, G. S., Shihab, E. M., Al-bahrani, M. H., Al‐Musawi, M. H., Nouri, K. M. M., Roshan, M. M., & Hajipour, H. (2025) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2025.103801 · Cited by 5 · see citing works

Olig2-enriched exosomes: A novel therapeutic approach for cuprizone-induced demyelination

Li, Y., He, J. M., Zhang, Q., Wei, B., Tao, X., Yu, C.-C., Shi, L., Wang, Z., Li, X., & Wang, L. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.021 · Cited by 4 · see citing works

Comprehensive account of exosome isolation from rat substantia nigra for mass spectrometry-based proteomics study

Ghosh, S., Ghosh, S., Jana, A., Roy, R., & Ghosh, S. (2025) · Methods · doi:10.1016/j.ymeth.2025.06.002 · Cited by 2 · see citing works

Diagnostic use of circulating cells and sub-cellular bio-particles

Tevlek, A. (2024) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2024.08.002 · Cited by 1 · see citing works

Development of engineered magnetic liposome/exosome hybrid as a novel caffeine nanocarrier for restraining liver fibrosis induced in rats

Elakkad, Y. E., Refai, H., Ahmed, H. H., Abdallah, A. N., Abdellatif, M. M., Mohawed, O. A. M., & Abohashem, R. S. (2026) · Scientific Reports · doi:10.1038/s41598-025-31169-w · Cited by 1 · see citing works

Regeneración corneal mediante tratamiento con vesículas extracelulares derivadas de células madre mesenquimales en un modelo murino de injuria alcalina

Cruz, D. M. S., Cantero, M. J., Fiore, E. J., & Pacienza, N. (2025) · Oftalmología clínica y experimental. · doi:10.70313/2718.7446.v18.n2.421

Dental Pulp Stem Cell-Derived Small Extracellular Vesicle miR-100-5p Attenuates Neuronal Oxidative Stress via Regulating the mTOR-Autophagy Signaling Axis

Zhou, W., Zhao, Y., Yang, F., Zhang, W., & Zhang, X. (2026) · Cells · doi:10.3390/cells15201843

Translational advances of exosomes in neurodegeneration towards precision healthcare: From biomarkers to therapeutic frontiers

Sharma, R., Song, B. S., Rane, R., Paul, D., Singh, B., Verma, T., Mishra, A., Karan, A., & Song, J. J. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119297 · Cited by 2 · see citing works

Exosomes, an Unmasked Culprit in Neurodegenerative Diseases

Soria, F. N., Pampliega, O., Bourdenx, M., Meissner, W. G., Bézard, E., & Dehay, B. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00026 · Cited by 144 · see citing works

Diagnostic and therapeutic potentials of exosomes in CNS diseases

Kawiková, I., & Askenase, P. W. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.070 · Cited by 144 · see citing works

Small but Mighty—Exosomes, Novel Intercellular Messengers in Neurodegeneration

Kumari, M., & Anji, A. (2022) · Biology · doi:10.3390/biology11030413 · Cited by 40 · see citing works

Function of exosomes in neurological disorders and brain tumors

Xiao, L., Hareendran, S., & Loh, Y. P. (2021) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2021.04 · Cited by 62 · see citing works