Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population
Open accessPublished version of a preprint
Abstract
In current clinical practice, genetic testing to detect Lynch syndrome mutations ideally begins with diagnostic testing of an individual affected with cancer before offering predictive testing to at-risk relatives. An alternative strategy that warrants exploration involves screening unaffected individuals via demographic and family histories, and offering genetic testing to those individuals whose risks for carrying a mutation exceed a selected threshold. Whether this approach would improve health outcomes in a manner that is cost-effective relative to current standards of care has yet to be demonstrated. To do so, we developed a simulation framework that integrated models of colorectal and endometrial cancers with a 5-generation family history model to predict health and economic outcomes of 20 primary screening strategies (at a wide range of compliance levels) aimed at detecting individuals with mismatch repair gene mutations and their at-risk relatives. These strategies were characterized by (i) different screening ages for starting risk assessment and (ii) different risk thresholds above which to implement genetic testing. For each strategy, 100,000 simulated individuals, representative of the U.S. population, were followed from the age of 20, and the outcomes were compared with current practice. Findings indicated that risk assessment starting at ages 25, 30, or 35, followed by genetic testing of those with mutation risks exceeding 5%, reduced colorectal and endometrial cancer incidence in mutation carriers by approximately 12.4% and 8.8%, respectively. For a population of 100,000 individuals containing 392 mutation carriers, this strategy increased quality-adjusted life-years (QALY) by approximately 135 with an average cost-effectiveness ratio of $26,000 per QALY. The cost-effectiveness of screening for mismatch repair gene mutations is comparable to that of accepted cancer screening activities in the general population such as colorectal cancer screening, cervical cancer screening, and breast cancer screening. These results suggest that primary screening of individuals for mismatch repair gene mutations, starting with risk assessment between the ages of 25 and 35, followed by genetic testing of those whose risk exceeds 5%, is a strategy that could improve health outcomes in a cost-effective manner relative to current practice.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Screening for Lynch syndrome has been proven cost-effective, and surveillance for colon cancer with regular colonoscopies significantly decreases morbidity and mortality in affected patients.
“Screening has been proven cost-effective, and surveillance for colon cancer with regular colonoscopies significantly decreases morbidity and mortality in affected patients (60, 61).”
From Adrenocortical carcinoma (2014) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer
Lieberman, D. A., Weiss, D. G., Bond, J. H., Ahnen, D. J., Garewal, H. S., Harford, W. V., Provenzale, D., SONTAG, S., Schnell, T., Durbin, T. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007203430301 · Cited by 1,810 · see citing works
Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
Hampel, H., Frankel, W. L., Martin, E., Arnold, M., Khanduja, K., Kuebler, P., Nakagawa, H., Sotamaa, K., Prior, T. W., Westman, J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043146 · Cited by 1,408 · see citing works
Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer
Gryfe, R., Kim, H., Hsieh, E., Aronson, M. D., Holowaty, E. J., Bull, S. B., Redston, M. S., & Gallinger, S. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001133420201 · Cited by 1,378 · see citing works
Järvinen, H. J., Aarnio, M., Mustonen, H., Aktan–Collan, K., Aaltonen, L. A., Peltomäki, P., Chapelle, A. D. L., & Mecklin, J. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70168-5 · Cited by 1,337 · see citing works
Aaltonen, L. A., Salovaara, R., Kristo, P., Canzian, F., Hemminki, A., Peltomäki, P., Chadwick, R. B., Kääriäinen, H., Eskelinen, M. J., Järvinen, H., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805213382101 · Cited by 1,150 · see citing works
Recommendations for Reporting Cost-effectiveness Analyses
Siegel, J. E. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540160061034 · Cited by 1,147 · see citing works
Siegel, J. E. (1996) · JAMA · doi:10.1001/jama.276.16.1339 · Cited by 1,040 · see citing works
Robson, M. E., Bradbury, A. R., Arun, B., Domchek, S. M., Ford, J. M., Hampel, H. L., Lipkin, S. M., Syngal, S., Wollins, D. S., & Lindor, N. M. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.0996 · Cited by 939 · see citing works
Self-citationWillingness to Pay for a Quality-adjusted Life Year: In Search of a Standard
Hirth, R. A., Chernew, M. E., Miller, E., Fendrick, A. M., & Weissert, W. G. (2000) · Medical Decision Making · doi:10.1177/0272989x0002000310 · Cited by 850 · see citing works
Vasen, H. F. A., Wijnen, J., Menko, F. H., KLEIBEUKER, J. H., Taal, B. G., Griffioen, G. G., Nagengast, F. M., Meijers-Heijboer, E. H., Bertario, L., Varesco, L., et al. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8612988 · Cited by 812 · see citing works
Self-citationProphylactic Surgery to Reduce the Risk of Gynecologic Cancers in the Lynch Syndrome
Schmeler, K. M., Lynch, H. T., Chen, L.-M., Munsell, M. F., Soliman, P. T., Clark, M. B., Daniels, M. S., White, K. G., Boyd-Rogers, S. G., Conrad, P. G., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052627 · Cited by 792 · see citing works
(2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.03.189 · Cited by 748 · see citing works
Cancer risk associated with germline DNA mismatch repair gene mutations
Dunlop, M. G. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.1.105 · Cited by 694 · see citing works
Priorities Among Effective Clinical Preventive Services
Maciosek, M. V., Coffield, A. B., Edwards, N. M., Flottemesch, T. J., Goodman, M. J., & Solberg, L. I. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.03.012 · Cited by 627 · see citing works
Cost-Effectiveness of Colonoscopy in Screening for Colorectal Cancer
Sonnenberg, A., Delcò, F., & Inadomi, J. M. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-8-200010170-00007 · Cited by 621 · see citing works
The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome
Watson, P. A., Vasen, H. F. A., Mecklin, J., Bernstein, I., Aarnio, M., Järvinen, H., Myrhøj, T., Sunde, L., Wijnen, J., & Lynch, H. T. (2008) · International Journal of Cancer · doi:10.1002/ijc.23508 · Cited by 594 · see citing works
Self-citationBraithwaite, R. S., Meltzer, D. O., King, J. T., Leslie, D., & Roberts, M. S. (2008) · Medical Care · doi:10.1097/mlr.0b013e31815c31a7 · Cited by 579 · see citing works
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)
Vasen, H. F. A., Möslein, G., Alonso, Á. M., et al. (2007) · Journal of Medical Genetics · doi:10.1136/jmg.2007.048991 · Cited by 554 · see citing works
Self-citationThe Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations
Senter, L. A., Clendenning, M., Sotamaa, K., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.026 · Cited by 552 · see citing works
Identification and Survival of Carriers of Mutations in DNA Mismatch-Repair Genes in Colon Cancer
Barnetson, R. A., Tenesa, A., Farrington, S. M., Nicholl, I. D., Cetnarskyj, R., Porteous, M. E., Campbell, H., & Dunlop, M. G. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053493 · Cited by 476 · see citing works
Palomaki, G. E., McClain, M. R., Melillo, S. N., et al. (2009) · Genetics in Medicine · doi:10.1097/gim.0b013e31818fa2db · Cited by 469 · see citing works
Hendriks, Y. M. C., Wagner, A., Morreau, H. M., Menko, F. H., Stormorken, A. T., Quehenberger, F., Sandkuijl, L. A., Møller, P., Genuardi, M., van Houwelingen, H. C., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.068 · Cited by 425 · see citing works
Self-citationRobson, M. E., Storm, C. D., Weitzel, J. N., Wollins, D. S., & Offit, K. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.0660 · Cited by 421 · see citing works
Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer Syndrome: Later Age of Onset
Hampel, H., STEPHENS, J., Pukkala, ., Sankila, R. J., Aaltonen, L. A., Mecklin, J., & DELACHAPELLE, A. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.011 · Cited by 400 · see citing works
Prediction of Germline Mutations and Cancer Risk in the Lynch Syndrome
Chen, S., Wang, W., Lee, S., Nafa, K., Lee, J., Romans, K., Watson, P. A., Gruber, S. B., Euhus, D., Kinzler, K. W., et al. (2006) · JAMA · doi:10.1001/jama.296.12.1479 · Cited by 385 · see citing works
Self-citationCalculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome
Stoffel, E., Mukherjee, B., Raymond, V. M., Tayob, N., Kastrinos, F., Sparr, J., Wang, F., Bandipalliam, P., Syngal, S., & Gruber, S. B. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.039 · Cited by 360 · see citing works
Self-citationCancer Risk in Hereditary Nonpolyposis Colorectal Cancer Syndrome: Later Age of Onset
Hampel, H., Stephens, J. A., Pukkala, ., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.011 · Cited by 357 · see citing works
Better survival rates in patients with MLH1-associated hereditary colorectal cancer
Sankila, R. J., Aaltonen, L. A., Järvinen, H., & Mecklin, J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8608876 · Cited by 354 · see citing works
Nelson, H. D., Huffman, L. H., Fu, R. F., & Harris, E. L. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-5-200509060-00012 · Cited by 345 · see citing works
Does This Patient Have a Family History of Cancer?
Murff, H. J., Spigel, D. R., & Syngal, S. (2004) · JAMA · doi:10.1001/jama.292.12.1480 · Cited by 315 · see citing works
Self-citationBurt, R. W., Barthel, J. S., Dunn, K. B., et al. (2010) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2010.0003 · Cited by 310 · see citing works
Self-citationEffect of Aspirin or Resistant Starch on Colorectal Neoplasia in the Lynch Syndrome
Burn, J., Bishop, D. T., Mecklin, J., Macrae, F., Möslein, G., Olschwang, S., Bisgaard, M.-L., Ramesar, R., Eccles, D., Maher, E. R., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801297 · Cited by 298 · see citing works
Self-citationMvundura, M., Grosse, S. D., Hampel, H., & Palomaki, G. E. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181cd666c · Cited by 292 · see citing works
Kahn, R., Alperin, P., Eddy, D., Borch-Johnsen, K., Buse, J., Feigelman, J., Gregg, E., Holman, R. R., Kirkman, M. S., Stern, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62162-0 · Cited by 287 · see citing works
Endometrial Cancer and Lynch Syndrome: Clinical and Pathologic Considerations
Meyer, L. A., Broaddus, R. R., & Lu, K. H. (2009) · Cancer Control · doi:10.1177/107327480901600103 · Cited by 281 · see citing works
Quehenberger, F., Vasen, H. F. A., & van Houwelingen, H. C. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024299 · Cited by 280 · see citing works
Self-citationDove‐Edwin, I., Boks, D. E. S., Goff, S., et al. (2002) · Cancer · doi:10.1002/cncr.10380 · Cited by 229 · see citing works
Dijkhuizen, F. P. H. L. J., Mol, B. W., Brölmann, H. A., & Heintz, A. P. M. (2000) · PubMed · Cited by 224 · see citing works
The role of mismatch repair gene defects in the development of adenomas in patients with HNPCC
Jong, A. E. V. D. M., Morreau, H. M., van Puijenbroek, M., et al. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.043 · Cited by 218 · see citing works
Colonoscopy: a review of its yield for cancers and adenomas by indication.
Rex, D. (1995) · PubMed · Cited by 210 · see citing works
Ara, R., & Brazier, J. E. (2008) · Value in Health · doi:10.1111/j.1524-4733.2008.00352.x · Cited by 208 · see citing works
Clinical features of colorectal carcinoma in cancer family syndrome
Mecklin, J., & Järvinen, H. (1986) · Diseases of the Colon & Rectum · doi:10.1007/bf02555012 · Cited by 204 · see citing works
Surveillance for hereditary nonpolyposis colorectal cancer - A long-term study on 114 families
Cappel, W., Nagengast, F. M., Griffioen, G. G., Menko, F. H., Taal, B. G., Kleibeuker, J. H., & Vasen, H. F. A. (2002) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.1097/01.dcr.0000034502.64985.3f · Cited by 204 · see citing works
Self-citationValidation of the Archimedes Diabetes Model
Eddy, D. M., & Schlessinger, L. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3102 · Cited by 192 · see citing works
Prediction of MLH1 and MSH2 Mutations in Lynch Syndrome
Balmañà, J., Stockwell, D. H., Steyerberg, E. W., Stoffel, E. M., Deffenbaugh, A. M., Reid, J., Ward, B. E., Scholl, T., Hendrickson, B. C., Tazelaar, J., et al. (2006) · JAMA · doi:10.1001/jama.296.12.1469 · Cited by 187 · see citing works
Self-citationSurveillance for Hereditary Nonpolyposis Colorectal Cancer
Cappel, W. H. D. V. T. N., Nagengast, F. M., Griffioen, G. G., Menko, F. H., Taal, B. G., Kleibeuker, J. H., & Vasen, H. F. A. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-7244-3 · Cited by 186 · see citing works
Self-citationKastrinos, F., Steyerberg, E. W., Mercado, R. C., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.021 · Cited by 185 · see citing works
Accuracy of reporting of family history of colorectal cancer
Mitchell, R. J., Brewster, D., Campbell, H., et al. (2004) · Gut · doi:10.1136/gut.2003.027896 · Cited by 182 · see citing works
Utility Valuations for Outcome States of Colorectal Cancer
Ness, R. M., Holmes, A. M., Klein, R., & Dittus, R. S. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01157.x · Cited by 181 · see citing works
Rijcken, F. E. M., Hollema, H., & Kleibeuker, J. K. (2002) · Gut · doi:10.1136/gut.50.3.382 · Cited by 176 · see citing works
Gross, C. P., McAvay, G., Krumholz, H. M., Paltiel, A. D., Bhasin, D., & Tinetti, M. E. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-9-200611070-00006 · Cited by 171 · see citing works
Jenkins, M. A., Baglietto, L., Dowty, J. G., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.01.002 · Cited by 171 · see citing works
Rectal Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer After Abdominal Colectomy
Rodrı́guez-Bigas, M. A., Vasen, H. F. A., Pekka-Mecklin, J., et al. (1997) · Annals of Surgery · doi:10.1097/00000658-199702000-00008 · Cited by 166 · see citing works
Self-citationAtypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree
Wagner, A., Hendriks, Y., Meijers-Heijboer, E. J., et al. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.5.318 · Cited by 166 · see citing works
Archimedes: a new model for simulating health care systems—the mathematical formulation
Schlessinger, L., & Eddy, D. M. (2002) · Journal of Biomedical Informatics · doi:10.1016/s1532-0464(02)00006-0 · Cited by 161 · see citing works
Ramsey, S. D., Yoon, P. W., Moonesinghe, R., et al. (2006) · Genetics in Medicine · doi:10.1097/01.gim.0000237867.34011.12 · Cited by 158 · see citing works
Grover, S., Stoffel, E. M., Bussone, L., et al. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00352-0 · Cited by 143 · see citing works
Development of Colorectal Tumors in Colonoscopic Surveillance in Lynch Syndrome
Mecklin, J., Aarnio, M., Läärä, E., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.019 · Cited by 139 · see citing works
Lin, K. M., Shashidharan, M., Thorson, A. G., Ternent, C. A., Blatchford, G. J., Christensen, M. A., Watson, P. A., Lemon, S. J., Franklin, B., Karr, B., et al. (1998) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(98)80105-4 · Cited by 137 · see citing works
Psychological Impact of Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer
Gritz, E. R., Peterson, S. K., Vernon, S. W., Marani, S. K., Baile, W. F., Watts, B. G., Amos, C. I., Frazier, M. L., & Lynch, P. M. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.07.102 · Cited by 134 · see citing works
Survival analysis of endometrial carcinoma associated with hereditary nonpolyposis colorectal cancer
Boks, D. E. S., Trujillo, A. P., Voogd, A. C., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10667 · Cited by 133 · see citing works
Burt, R. W., Cannon, J. A., David, D. S., Early, D. S., Ford, J. M., Giardiello, F. M., Halverson, A. L., Hamilton, S. R., Hampel, H., Ismail, M. K., et al. (2013) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2013.0180 · Cited by 126 · see citing works
Self-citationAdenoma prevalence and cancer risk in familial non-polyposis colorectal cancer
Lindgren, G., Liljegren, A., Jaramillo, E., et al. (2002) · Gut · doi:10.1136/gut.50.2.228 · Cited by 124 · see citing works
Clinical Description of the Lynch Syndrome [Hereditary Nonpolyposis Colorectal Cancer (HNPCC)]
Vasen, H. F. A. (2005) · Familial Cancer · doi:10.1007/s10689-004-3906-5 · Cited by 110 · see citing works
Self-citationRenkonen‐Sinisalo, L., Aarnio, M., Mecklin, J., et al. (2000) · PubMed · Cited by 110 · see citing works
Deficient DNA Mismatch Repair Is Common in Lynch Syndrome-Associated Colorectal Adenomas
Pino, M. S., Mino-Kenudson, M. A., Wildemore, B., et al. (2009) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2009.080142 · Cited by 105 · see citing works
Barrow, E., Alduaij, W., Robinson, L. A., et al. (2008) · Clinical Genetics · doi:10.1111/j.1399-0004.2008.01035.x · Cited by 101 · see citing works
Cost‐effectiveness analysis of prevention strategies for gynecologic cancers in Lynch syndrome
Kwon, J. S., Sun, C. C., Peterson, S. K., et al. (2008) · Cancer · doi:10.1002/cncr.23554 · Cited by 99 · see citing works
Wagner, A., van Kessel, I., Kriege, M., et al. (2005) · Familial Cancer · doi:10.1007/s10689-005-0658-9 · Cited by 96 · see citing works
van Duijvendijk, P., Slors, J. F. M., Taat, C. W., Oosterveld, P., Sprangers, M. A. G., Obertop, H., & Vasen, H. F. A. (2000) · British journal of surgery · doi:10.1046/j.1365-2168.2000.01442.x · Cited by 96 · see citing works
Self-citationEstablishment of a human hemangiosarcoma cell line (ISO-HAS)
Masuzawa, M., Fujimura, T., Hamada, Y., Fujita, Y., Hara, H., Nishiyama, S., Katsuoka, K., Tamauchi, H., & Sakurai, Y. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990412)81:2 · Cited by 81 · see citing works
Prognosis of colorectal cancer varies in different high-risk conditions
Aarnio, M., Mustonen, H. K., Mecklin, J., & Järvinen, H. (1998) · Annals of Medicine · doi:10.3109/07853899808999387 · Cited by 81 · see citing works
Collins, V., Meiser, B., Gaff, C., John, D., & Halliday, J. L. (2005) · Cancer · doi:10.1002/cncr.21183 · Cited by 77 · see citing works
Underdiagnosis of Lynch Syndrome Involves More Than Family History Criteria
Singh, H., Schiesser, R. L., Anand, G. S., et al. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.03.010 · Cited by 76 · see citing works
Buttin, B. M., Powell, M. A., Mutch, D. G., Babb, S. A., Huettner, P. C., Edmonston, T. B., Herzog, T. J., Rader, J. S., Gibb, R. K., Whelan, A. J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/421332 · Cited by 68 · see citing works
Gynecologic cancers associated with Lynch syndrome/HNPCC
Schmeler, K. M., & Lu, K. H. (2008) · Clinical & Translational Oncology · doi:10.1007/s12094-008-0206-9 · Cited by 51 · see citing works
Liljegren, A., Barker, G., Elliott, F., Bertario, L., Bisgaard, M. L., Eccles, D., Evans, D. G., Macrae, F., Maher, E. R., Lindblom, A., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.2795 · Cited by 50 · see citing works
Ramsey, S. D., Burke, W., & Clarke, L. (2003) · Genetics in Medicine · doi:10.1097/01.gim.0000086626.03082.b5 · Cited by 45 · see citing works
Cancer surveillance is often inadequate in people at high risk for colorectal cancer
Stoffel, E. M., Garber, J. E., Grover, S., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.5.e54 · Cited by 29 · see citing works
Standards of care in diagnosis and testing for hereditary colon cancer
Lynch, P. M. (2007) · Familial Cancer · doi:10.1007/s10689-007-9159-3 · Cited by 25 · see citing works
Kern, W., Behre, G., Rudolf, T., Kerkhoff, A., Grote‐Metke, A., Eimermacher, H., Kubica, U., Wormann, B. J., Büchner, T., & Hiddemann, W. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980715)83:2 · Cited by 19 · see citing works
A computer model to simulate family history of breast/ovarian cancer in BRCA1 mutation carriers
Bajdik, C. D., Raboud, J., Schechter, M. T., et al. (2001) · Mathematical Biosciences · doi:10.1016/s0025-5564(01)00052-9 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [77]Zauber AG Lansdorp-Vogelaar I Wilschut J Knudsen AB van Ballegooijen M Kuntz KM Cost-effectiveness of DNA stool testing to screen for colorectal cancer: Report to Agency for Healthcare Research and Quality (AHRQ) and CMS from the Cancer Intervention and Surveillance Modeling Network (CISNET) for MISCAN and SimCRC Models 2007 25879132
Cited by
Sorted by citations
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662 · see citing works
Self-citationElse, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
Adrenocortical carcinoma is a Lynch syndrome-associated cancer
Raymond, V. M., Everett, J. N., Furtado, L. V., Gustafson, S. L., Jungbluth, C. R., Gruber, S. B., Hammer, G. D., Stoffel, E. M., Greenson, J. K., Giordano, T. J., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.0988 · Cited by 208 · see citing works
Self-citationFamily health history: underused for actionable risk assessment
Ginsburg, G. S., Wu, R. R., & Orlando, L. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31275-9 · Cited by 105 · see citing works
- Authors
- Dinh, T. A., Rosner, B. I., Atwood, J. C., Boland, C. R., Syngal, S., Vasen, H. F. A., Gruber, S. B., & Burt, R. W.
- Affiliations
- Leiden University (NL)
- Corresponding author
- Gruber, Stephen B.
- Venue
- Cancer Prevention Research
- Published
- 2011-01-01
- Volume
- 4
- Issue
- 1
- Pages
- 9-22
- ISSN
- 1940-6207 (ISSN-L)
- 1940-6215
- PMC
- PMC3793254
- OpenAlex
- W2103848163
- Cited by
- 175
- References
- 84
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 10 · 2018: 10 · 2017: 12 · 2016: 7 · 2015: 21 · 2014: 20 · 2013: 25 · 2012: 17
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Cancer Prevention Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Cancer Institute (R01CA072851)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- Lynch syndrome, mismatch repair gene mutations, predictive genetic testing, colorectal cancer, endometrial cancer, family history (medicine), risk assessment, cost-effectiveness, quality-adjusted life years, cancer incidence, computer simulation
- MeSH terms
- Adult, Colorectal Neoplasms, Hereditary Nonpolyposis, Cost-Benefit Analysis, Female, Genetic Testing, Humans, Michigan, Mutation, Neoplasm Proteins, Incidence, Endometrial Neoplasms, Risk Assessment, Quality-Adjusted Life Years, Standard of Care
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
