Metformin and Cancer Stem Cells: Old Drug, New Targets
Published version of a preprint
Abstract
In this issue of the journal, Bao and colleagues report (beginning on page 355) that the antidiabetic drug metformin targets pancreatic cancer stem cells through, at least partially, the modulation of miRNA expression and subsequent regulation of stem cell renewal and signaling factors. In this Perspective, we briefly discuss the cancer stem cell hypothesis, its clinical relevance, and how targeting the mTOR pathway may yield an avenue for disrupting the cancer stem cell compartment and thus yield long-term therapeutic benefit in multiple cancers. Cancer Prev Res; 5(3); 351–4. ©2012 AACR.
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Metformin might exert direct anticancer effects on a range of tumor cells, including cancer stem cells.
“Recent studies have indicated that metformin might exert direct anticancer effects on a range of tumor cells, including the elusive CSCs,197,198”
From Drug repurposing for cancer therapy (2024) · cites this paper as [197]
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Karmokar, A. (2014) · Figshare
- Authors
- Bednar, F., & Simeone, D. M.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Simeone, Diane M.
- Venue
- Cancer Prevention Research
- Published
- 2012-03-01
- Volume
- 5
- Issue
- 3
- Pages
- 351-354
- ISSN
- 1940-6207 (ISSN-L)
- 1940-6215
- OpenAlex
- W1992381541
- Cited by
- 51
- References
- 33
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 10 · 2013: 4 · 2012: 4
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Prevention Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- metformin, cancer stem cells, pancreatic cancer, microRNA expression, mTOR signaling, stem cell self-renewal, anticancer drug repurposing, cancer stem cell hypothesis
- MeSH terms
- Animals, Cell Movement, Female, Humans, Hypoglycemic Agents, Metformin, Pancreatic Neoplasms, Neoplastic Stem Cells, MicroRNAs, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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