Inhibition of Lung Tumorigenesis by Metformin Is Associated with Decreased Plasma IGF-I and Diminished Receptor Tyrosine Kinase Signaling

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Cancer Statistics, 2010

Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

Engelman, J. A., Zejnullahu, K., Mitsudomi, T., Song, Y., Hyland, C., Park, J. O., Lindeman, N., Gale, C.-M., Zhao, X., Christensen, J., et al. (2007) · Science · doi:10.1126/science.1141478 · Cited by 4,496

Fibroblast growth factor signalling: from development to cancer

Turner, N. C., & Grose, R. P. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2780 · Cited by 2,768

Metformin and reduced risk of cancer in diabetic patients

Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005) · BMJ · doi:10.1136/bmj.38415.708634.f7 · Cited by 2,388

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157

Insulin and insulin-like growth factor signalling in neoplasia

Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

Prevalence of ras gene mutations in human colorectal cancers

Bos, J. L., Fearon, E. R., Hamilton, S. R., Vries, M. V., BOOM, J. H. V., van der Eb, A. J., & Vogelstein, B. (1987) · Nature · doi:10.1038/327293a0 · Cited by 1,860

Autocrine growth factors and cancer

Sporn, M. B., & Roberts, A. B. (1985) · Nature · doi:10.1038/313745a0 · Cited by 1,425

Normal growth and development in the absence of hepatic insulin-like growth factor I

Yakar, S., Liu, J., STANNARD, B. S., Butler, A. A., Accili, D., Sauer, B., & LeRoith, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7324 · Cited by 1,418

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399

Clinical pharmacokinetics of metformin

Graham, G. G., Punt, J., Arora, M., Day, R. O., Doogue, M. P., Duong, J. K., Furlong, T. J., Greenfield, J. R., Greenup, L. C., Kirkpatrick, C. M., et al. (2011) · Clinical Pharmacokinetics · doi:10.2165/11534750-000000000-00000 · Cited by 1,318

The discovery of receptor tyrosine kinases: targets for cancer therapy

Gschwind, A., Fischer, O. M., & Ullrich, A. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1360 · Cited by 1,227

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.620 · Cited by 1,118

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2063 · Cited by 1,052 · cited 1×

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

Dowling, R. J. O., Zakikhani, M., Fantus, I. G., Pollak, M., & Sonenberg, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2310 · Cited by 933

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

DeCensi, A., Puntoni, M., Goodwin, P., Cazzaniga, M., Gennari, A., Bonanni, B., & Gandini, S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0157 · Cited by 918

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Vigil, D., Cherfils, J., Rossman, K. L., & Der, C. J. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2960 · Cited by 850

Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

‡ (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70095-4 · Cited by 665

Tyrosine phosphorylation: thirty years and counting

Hunter, T. R. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.028 · Cited by 664

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1

Ben Sahra, I., Regazzetti, C., Robert, G., Laurent, K., Le Marchand-Brustel, Y., Auberger, P., Tanti, J.-F., Giorgetti-Peraldi, S., & Bost, F. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1769 · Cited by 616

The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis

Mascaux, C., Iannino, N., Martin, B., Paesmans, M., Berghmans, T., Dusart, M., Haller, A., Lothaire, P., Meert, A.-P., Noël, S., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602258 · Cited by 615

Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents

Sharma, S. V., Haber, D. A., & Settleman, J. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2820 · Cited by 600

The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.

Zarnegar, R., & Michalopoulos, G. K. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.5.1177 · Cited by 569

Phase I/II Trial Evaluating the Anti-Vascular Endothelial Growth Factor Monoclonal Antibody Bevacizumab in Combination With the HER-1/Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib for Patients With Recurrent Non–Small-Cell Lung Cancer

Herbst, R. S., Johnson, D. H., Mininberg, E. D., Carbone, D. P., Henderson, T., Kim, E. S., Blumenschein, G., Lee, J. J., Liu, D. D., Truong, M. T., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.477 · Cited by 526

5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

Laderoute, K. R., Amin, K., Calaoagan, J. M., Knapp, M., Le, T., Orduna, J. M., Foretz, M., & Viollet, B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-06 · Cited by 450

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

Wang, D.-S., Jonker, J. W., Kato, Y., Kusuhara, H., Schinkel, A. H., & Sugiyama, Y. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034140 · Cited by 441

Cloning and Functional Expression of a Human Liver Organic Cation Transporter

Zhang, L., Dresser, M. J., Gray, A. T., Yost, S. C., Terashita, S., & Giacomini, K. M. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.6.913 · Cited by 416

Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis

Memmott, R. M., Mercado, J. R., Maier, C. R., Kawabata, S., Fox, S. D., & Dennis, P. A. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0055 · Cited by 416

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M., et al. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.007 · Cited by 402

Inhibition of Ras for Cancer Treatment: The Search Continues

Baines, A. T., Xu, D., & Der, C. J. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.121 · Cited by 401

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

Liu, B., Fan, Z., Edgerton, S. M., Deng, X.-S., Alimova, I. N., Lind, S. E., & Thor, A. D. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8814 · Cited by 392

Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

Wu, Y., Yakar, S., Zhao, L., Hennighausen, L. G., & LeRoith, D. (2002) · PubMed · Cited by 380

Targeting the mTOR signaling network in cancer

Chiang, G. G., & Abraham, R. T. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.08.001 · Cited by 332

Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase

Sun, T., Aceto, N., Meerbrey, K. L., Kessler, J. D., Zhou, C., Migliaccio, I., Nguyen, D. X., Pavlova, N. N., Botero, M. F., Huang, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.003 · Cited by 281

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

Gualberto, A., & Pollak, M. (2009) · Oncogene · doi:10.1038/onc.2009.172 · Cited by 275

K-ras as a target for cancer therapy

Friday, B. B., & Adjei, A. A. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.08.001 · Cited by 248

Ras Family Signaling: Therapeutic Targeting

Cox, A. D., & Der, C. J. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.306 · Cited by 212

Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines

Belinsky, S. A. (1990) · Lung Cancer · doi:10.1016/0169-5002(90)90262-k · Cited by 209

Insulin-Like Growth Factor-I Affects Perinatal Lethality and Postnatal Development in a Gene Dosage-Dependent Manner: Manipulation Using the Cre/loxP System in Transgenic Mice

Liu, J., Grinberg, A., Westphal, H., Sauer, B., Accili, D., Karas, M., & LeRoith, D. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.9.0162 · Cited by 205

High Levels of Circulating Insulin-Like Growth Factor-I Increase Prostate Cancer Risk: A Prospective Study in a Population-Based Nonscreened Cohort

Stattin, P. E., Rinaldi, S., Biessy, C., Stenman, U., Hallmans, G., & Kaaks, R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.10.105 · Cited by 155

Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.

Shibata, D., Almoguera, C., Forrester, K., Dunitz, J., Martin, S. E., Cosgrove, M. M., Perucho, M., & Arnheim, N. (1990) · PubMed · Cited by 132

The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients

Ersoy, C., Kiyici, S. K., Budak, F., Oral, H. B., Güçlü, M., Duran, C., Selimoğlu, H., Ertürk, E., Tuncel, E., & İmamoğlu, Ş. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.02.006 · Cited by 127

Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions

Liu, B., Fan, Z., Edgerton, S. M., Yang, X., Lind, S. E., & Thor, A. D. (2011) · Cell Cycle · doi:10.4161/cc.10.17.16359 · Cited by 120

Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen–Induced Murine Lung Tumors

Granville, C. A., Warfel, N. A., Tsurutani, J., Hollander, M. C., Robertson, M., Fox, S. D., Veenstra, T. D., Issaq, H. J., Linnoila, R. I., & Dennis, P. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2570 · Cited by 96

Elevated Epithelial Insulin-like Growth Factor Expression Is a Risk Factor for Lung Cancer Development

Kim, W.-Y., Jin, Q., Oh, S.-H., Kim, E. S., Yang, Y. J., Lee, D. H., Feng, L., Behrens, C., Prudkin, L., Miller, Y. E., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3792 · Cited by 78

Reduced Susceptibility to Two-Stage Skin Carcinogenesis in Mice with Low Circulating Insulin-Like Growth Factor I Levels

Moore, T., Carbajal, S., Beltrán, L., Perkins, S. N., Yakar, S., LeRoith, D., Hursting, S. D., & DiGiovanni, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6271 · Cited by 68

Genetic Reduction of Insulin-like Growth Factor-1 Mimics the Anticancer Effects of Calorie Restriction on Cyclooxygenase-2–Driven Pancreatic Neoplasia

Lashinger, L. M., Malone, L. M., McArthur, M. J., Goldberg, J. A., Daniels, E. A., Pavone, A., Colby, J. K., Smith, N. C. P., Perkins, S. N., Fischer, S. M., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0027 · Cited by 58

Association between Circulating Levels of IGF-1 and IGFBP-3 and Lung Cancer Risk: A Meta-Analysis

Cao, H., Wang, G., Meng, L., Shen, H., Feng, Z., Liu, Q., & Du, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049884 · Cited by 56

Fibroblast Growth Factor Signaling in Non–Small-Cell Lung Cancer

Semrad, T. J., & Mack, P. C. (2011) · Clinical Lung Cancer · doi:10.1016/j.cllc.2011.08.001 · Cited by 48

Epidermal Growth Factor Induces Cell Proliferation in Mouse Pancreas and Salivary Glands

Ohlsson, B., Jansen, C., Ihse, I., & Axelson, J. (1997) · Pancreas · doi:10.1097/00006676-199701000-00014 · Cited by 28

Abnormalities of platelet-derived growth factors in insulin-dependent diabetes

Hamet, P., Sugimoto, H., Umeda, F., Lecavalier, L., Franks, D. J., Orth, D. N., & Chiasson, J. (1985) · Metabolism · doi:10.1016/s0026-0495(85)80006-8 · Cited by 27

Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients

Wang, J., Lian, S., Chen, Y. F., Yang, Y., Chen, L. T., Lee, K. T., Huang, T., & Lin, S. R. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00818-7 · Cited by 26

Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression

Jones‐Bolin, S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.8.1503 · Cited by 16

Targeting FGFR, Ephrins, Mer, MET, and PDGFR-α in Non-small Cell Lung Cancer

Riess, J. W., & Neal, J. W. (2011) · Journal of Thoracic Oncology · doi:10.1097/01.jto.0000407562.07029.52 · Cited by 4

Metformin as a tool to target aging

Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096

Metformin: update on mechanisms of action and repurposing potential

Foretz, M., Guigas, B., & Viollet, B. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00833-4 · Cited by 791

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Hegde, M., Girisa, S., BharathwajChetty, B., Vishwa, R., & Kunnumakkara, A. B. (2023) · ACS Omega · doi:10.1021/acsomega.2c07326 · Cited by 338

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.03.007 · Cited by 299

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?

Xu, Y., Xue, D., Bankhead, A., & Neamati, N. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01013 · Cited by 173

Metformin Targets Multiple Signaling Pathways in Cancer

Lei, Y., Yi, Y., Liu, Y., Liu, X., Keller, E. T., Qian, C.-N., Zhang, J., & Lu, Y. (2017) · Chinese Journal of Cancer · doi:10.1186/s40880-017-0184-9 · Cited by 152

Antidiabetic drug metformin prevents progression of pancreatic cancer by targeting in part cancer stem cells and mTOR signaling

Mohammed, A., Janakiram, N. B., Brewer, M., Ritchie, R. L., Marya, A., Lightfoot, S., Steele, V. E., & Rao, C. V. (2013) · Translational Oncology · doi:10.1593/tlo.13556 · Cited by 142

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy

Dowling, R. J. O., Lam, S. H. L., Bassi, C., Mouaaz, S., Aman, A. M., Kiyota, T., Al‐awar, R., Goodwin, P. J., & Stambolic, V. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.006 · Cited by 118

Rationalizing the therapeutic potential of apigenin against cancer

Ahmed, S. A., Parama, D., Daimari, E., Girisa, S., Banik, K., Harsha, C., Dutta, U., & Kunnumakkara, A. B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118814 · Cited by 114

A Randomized Phase II Study of Metformin plus Paclitaxel/Carboplatin/Bevacizumab in Patients with Chemotherapy-Naïve Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer

Marrone, K. A., Zhou, X. C., Forde, P. M., Purtell, M., Brahmer, J. R., Hann, C. L., Kelly, R. J., Coleman, B., Gabrielson, E. W., Rosner, G. L., et al. (2018) · The Oncologist · doi:10.1634/theoncologist.2017-0465 · Cited by 99

Metformin: current clinical applications in nondiabetic patients with cancer

Chen, K., Li, Y., Guo, Z., Zeng, Y., Zhang, W., & Wang, H. (2020) · Aging · doi:10.18632/aging.102787 · Cited by 90

Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells

Chen, Y., Yang, S., Yang, C.-K., Tsai, H., Chen, T.-H., Chou, M., & Hsiao, Y.-H. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11725 · Cited by 91

In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin

Laustriat, D., Gide, J., Barrault, L., Chautard, É., Benoit‐Pilven, C., Auboeuf, D., Boland, A., Battail, C., Artiguenave, F., Deleuze, J., et al. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.35 · Cited by 91

Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study

Du, Y., Zhu, Y., Zhou, Y., Ding, J., & Liu, J. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00108-w · Cited by 84

Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis

DePeralta, D. K., Wei, L., Ghoshal, S., Schmidt, B. H., Lauwers, G. Y., Lanuti, M. D., Chung, R. T., Tanabe, K. K., & Fuchs, B. C. (2016) · Cancer · doi:10.1002/cncr.29912 · Cited by 80

Translating the Science of Aging into Therapeutic Interventions

Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78

Metformin for cancer and aging prevention: is it a time to make the long story short?

Anisimov, V. N. (2015) · Oncotarget · doi:10.18632/oncotarget.6347 · Cited by 77

Metformin and Breast Cancer: Molecular Targets

Faria, J., Negalha, G. D. C., Azevedo, A., & Martel, F. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09429-z · Cited by 79

Metformin as a Therapeutic Target in Endometrial Cancers

Lee, T. Y., Martinez‐Outschoorn, U., Schilder, R. J., Kim, C. H., Richard, S. D., Rosenblum, N. G., & Johnson, J. M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00341 · Cited by 76

Metformin in Lung Cancer: Review of in Vitro and in Vivo Animal Studies

Yousef, M., & Tsiani, E. (2017) · Cancers · doi:10.3390/cancers9050045 · Cited by 75

Metformin protects primary rat hepatocytes against oxidative stress‐induced apoptosis

de la Rosa, L. C., Vrenken, T. E., Buist‐Homan, M., Faber, K. N., & Moshage, H. J. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.125 · Cited by 66

Metformin therapy associated with survival benefit in lung cancer patients with diabetes

Wan, G., Yu, X., Chen, P., Wang, X., Pan, D., Wang, X., Li, L., Cai, X., & Cao, F. (2016) · Oncotarget · doi:10.18632/oncotarget.8881 · Cited by 59

Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin

Anisimov, V. N., Popovich, I. G., Zabezhinski, M. A., Egormin, P. A., Yurova, M. N., Semenchenko, A. V., Тындык, М. Л., Панченко, А. В., Trashkov, A. P., Vasiliev, A. G., et al. (2014) · Cell Cycle · doi:10.4161/15384101.2014.973308 · Cited by 58

Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms

Ge, G., Xu, T., & Chen, C. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv041 · Cited by 55

Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life SpanPreprint

Milman, S., & Barzilai, N. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025098 · Cited by 53

microRNAs and cancer metabolism reprogramming: the paradigm of metformin.

Pulito, C., Donzelli, S., Muti, P. C., Puzzo, L., Strano, S., & Blandino, G. (2014) · PubMed Central · doi:10.3978/j.issn.2305-5839.2014.06.03 · Cited by 49

The promising potential of piperlongumine as an emerging therapeutics for cancer

Dey, P., Rana, V., Girisa, S., Verma, E., Daimary, U. D., Thakur, K. K., Kumar, A., & Kunnumakkara, A. B. (2021) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2021.00049 · Cited by 47

Oncobiguanides: Paracelsus' law and nonconventional routes for administering diabetobiguanides for cancer treatment

Menéndez, J. A., Quirantes‐Piné, R., Rodríguez‐Gallego, E., Cufí, S., Corominas-Faja, B., Cuyàs, E., Bosch‐Barrera, J., Martı́n-Castillo, B., Segura‐Carretero, A., & Joven, J. (2014) · Oncotarget · doi:10.18632/oncotarget.1965 · Cited by 43

Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review

Sailo, B. L., Liu, L., Chauhan, S., Girisa, S., Hegde, M., Liang, L., Alqahtani, M. S., Abbas, M. A. E., Sethi, G., & Kunnumakkara, A. B. (2024) · Cancers · doi:10.3390/cancers16020244 · Cited by 41

Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta-analysis

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Guo, Y., Yu, T., Yang, J., Zhang, T., Zhou, Y., He, F., Kurago, Z., Myssiorek, D. J., Wu, Y., Lee, P., et al. (2015) · PubMed Central · Cited by 16

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Wang, G., Li, X., Xiong, R., Wu, H., Xu, M., & Xie, M. (2020) · Thoracic Cancer · doi:10.1111/1759-7714.13398 · Cited by 11

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Troconis, N. (2021) · doi:10.47307/gmc.2021.129.1.12 · Cited by 2

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Campbell, J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00013-8 · Cited by 2

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Chang, H.-W. K., & Chang, V. H. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819668-7.00010-5 · Cited by 2

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Morris, K., Reboe, M., & Levy, A. (2016) · West Indian Medical Journal · doi:10.7727/wimj.2015.456

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BindingDB (2024) · UC San Diego · doi:10.7270/q2zg6xmn

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Quinn, B. J., Dallos, M. C., Kitagawa, H., Kunnumakkara, A. B., Memmott, R. M., Gills, J. J., Hollander, M. C., & Dennis, P. A. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.prev-12-pr-01

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Memmott, R. M., Mercado, J. R., Maier, C. R., Kawabata, S., Fox, S. D., & Dennis, P. A. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0055 · Cited by 416

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