Cited by 36Colorectal Cancer Treatments and StudiesHER2/EGFR in Cancer ResearchLung Cancer Treatments and Mutations

HER2 Signaling and Resistance to the Anti-EGFR Monoclonal Antibody Cetuximab: A Further Step toward Personalized Medicine for Patients with Colorectal Cancer

Ciardiello, Fortunato, Normanno, Nicola·2011·Cancer Discovery

Abstract

Primary and acquired resistance to anti-epidermal growth factor receptor (EGFR) drugs are clinically relevant problems in patients with metastatic colorectal carcinoma. A complex network of molecular alterations is involved in this phenomenon. Bertotti et al. report the development of serially transplantable groups of tumor xenografts in immune-deficient mice from patient-derived, genetically characterized metastatic colorectal carcinoma samples. These experimental models (“xenopatients”) might represent a novel approach to discover and characterize the mechanisms of resistance to anti-EGFR therapy and other molecularly targeted therapies in metastatic colorectal carcinoma. In this respect, Bertotti et al. were able to identify HER2 gene amplification as one such mechanism of resistance to anti-EGFR therapy. Cancer Discovery; 1(6); 472–74. ©2011 AACR. Commentary on Bertotti et al., p. 508.

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Registry

Crossref · 10.1158/2159-8290.cd-11-0261

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10 of 10 references verified0 citation errors · 0 not checkable

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Authors
Ciardiello, F., & Normanno, N.
Affiliations
University of Campania "Luigi Vanvitelli" (IT)
Venue
Cancer Discovery
Published
2011-11-01
Volume
1
Issue
6
Pages
472-474
ISSN
  • 2159-8274 (ISSN-L)
  • 2159-8290
OpenAlex
W2163088994
Cited by
36
References
11
Citations by year
2026: 2 · 2025: 2 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
0.95
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Discovery (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Keywords
HER2 amplification, cetuximab, anti-EGFR monoclonal antibody, drug resistance, metastatic colorectal cancer, patient-derived xenografts, immunodeficient mice, targeted therapy, personalized medicine
MeSH terms
Cetuximab, Animals, Antibodies, Monoclonal, Female, Humans, Male, Colorectal Neoplasms, Erb-b2 Receptor Tyrosine Kinases, Receptor, ErbB-2, Xenograft Model Antitumor Assays, Antibodies, Monoclonal, Humanized

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