The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement
Abstract
RNA interference (RNAi) is a potent and specific mechanism for regulating gene expression. Harnessing RNAi to silence genes involved in disease holds promise for the development of a new class of therapeutics. Delivery is key to realizing the potential of RNAi, and lipid nanoparticles (LNP) have proved effective in delivery of siRNAs to the liver and to tumors in animals. To examine the activity and safety of LNP-formulated siRNAs in humans, we initiated a trial of ALN-VSP, an LNP formulation of siRNAs targeting VEGF and kinesin spindle protein (KSP), in patients with cancer. Here, we show detection of drug in tumor biopsies, siRNA-mediated mRNA cleavage in the liver, pharmacodynamics suggestive of target downregulation, and antitumor activity, including complete regression of liver metastases in endometrial cancer. In addition, we show that biweekly intravenous administration of ALN-VSP was safe and well tolerated. These data provide proof-of-concept for RNAi therapeutics in humans and form the basis for further development in cancer. Significance: The findings in this report show safety, pharmacokinetics, RNAi mechanism of action, and clinical activity with a novel first-in-class LNP-formulated RNAi therapeutic in patients with cancer. The ability to harness RNAi to facilitate specific multitargeting, as well as increase the number of druggable targets, has important implications for future drug development in oncology. Cancer Discov; 3(4); 406–17. ©2012 AACR. This article is highlighted in the In This Issue feature, p. 363
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Metadata
- Authors
- Tabernero, J., Shapiro, G. I., LoRusso, P. M., Cervantes, A., Schwartz, G. K., Weiss, G. J., Paz-Ares, L., Cho, D. C., Infante, J. R., Alsina, M., Gounder, M. M., Falzone, R., Harrop, J., White, A. C. S., Toudjarska, I., Bumcrot, D., Meyers, R. E., Hinkle, G., Svrzikapa, N., Hutabarat, R. M., Clausen, V. A., Cehelsky, J., Nochur, S. V., Gamba-Vitalo, C., Vaishnaw, A. K., Sah, D. W. Y., Gollob, J. A., & Burris, H. A.
- Venue
- Cancer Discovery
- Published
- 2013-04-01
- Volume
- 3
- Issue
- 4
- Pages
- 406-417
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W2149896139
- Cited by
- 698
- References
- 42
- FWCI
- 34.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tabernero, J., Shapiro, G. I., LoRusso, P. M., Cervantes, A., Schwartz, G. K., Weiss, G. J., Paz-Ares, L., Cho, D. C., Infante, J. R., Alsina, M., Gounder, M. M., Falzone, R., Harrop, J., White, A. C. S., Toudjarska, I., Bumcrot, D., Meyers, R. E., Hinkle, G., Svrzikapa, N., . . . Burris, H. A. (2013). First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement. Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-12-0429
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
