Beyond DNA Repair: DNA-PK Function in Cancer

Recurrent Fusion of <i>TMPRSS2</i> and ETS Transcription Factor Genes in Prostate Cancer

Tomlins, S. A., Rhodes, D. R., Perner, S., Dhanasekaran, S. M., Mehra, R., Sun, X.-W., Varambally, S., Cao, X., Tchinda, J., Kuefer, R., et al. (2005) · Science · doi:10.1126/science.1117679 · Cited by 3,846 · see citing works

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882 · see citing works

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009 · see citing works

Mechanism of Eukaryotic Homologous Recombination

Filippo, J. S., Sung, P., & Klein, H. L. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.125255 · Cited by 1,686 · see citing works

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,629 · see citing works

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,481 · see citing works

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,445 · see citing works

Integration of Oxygen Signaling at the Consensus HRE

Wenger, R. H., Stiehl, D. P., & Camenisch, G. (2005) · Science's STKE · doi:10.1126/stke.3062005re12 · Cited by 1,032 · see citing works

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

Escribano‐Diaz, C., Orthwein, A., Fradet‐Turcotte, A., Xing, M., Young, J. T. F., Tkáč, J., Cook, M. A., Rosebrock, A. P., Munro, M., Canny, M. D., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.001 · Cited by 903 · see citing works

A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

Ju, B., Lunyak, V. V., Perissi, V., García-Bassets, I., Rose, D. W., Glass, C. K., & Rosenfeld, M. G. (2006) · Science · doi:10.1126/science.1127196 · Cited by 842 · see citing works

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Kim, S.-T., Lim, D.-S., Canman, C. E., & Kastan, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37538 · Cited by 810 · see citing works

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794 · see citing works

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Hartley, K. O., Gell, D. A., Smith, G. C. M., Zhang, H., Divecha, N., Connelly, M. A., Admon, A., Lees‐Miller, S. P., Anderson, C. W., & Jackson, S. P. (1995) · Cell · doi:10.1016/0092-8674(95)90482-4 · Cited by 745 · see citing works

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., & Greenberg, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.04.038 · Cited by 737 · see citing works

Innate Recognition of Viruses

Pichlmair, A., & Sousa, C. R. E. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.012 · Cited by 690 · see citing works

Comparison of nonhomologous end joining and homologous recombination in human cells

Mao, Z., Bozzella, M. J., Seluanov, A., & Gorbunova, V. A. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.06.018 · Cited by 673 · see citing works

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

Jackson, S. P., MacDonald, J. J., Lees‐Miller, S. P., & Tjian, R. (1990) · Cell · doi:10.1016/0092-8674(90)90296-q · Cited by 669 · see citing works

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Shibata, A., Moiani, D., Arvai, A. S., Perry, J. J. P., Harding, S. M., Genois, M., Maity, R., van Rossum-Fikkert, S. E., Kertokalio, A., Romoli, F., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.11.003 · Cited by 564 · see citing works

ATM and Artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2

Beucher, A., Birraux, J., Tchouandong, L., Barton, O., Shibata, A., Conrad, S., Goodarzi, A. A., Krempler, A., Jeggo, P. A., & Löbrich, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.276 · Cited by 548 · see citing works

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaksPreprint

Chan, D. W., Chen, B. P.-C., Prithivirajsingh, S., Kurimasa, A., Story, M. D., Qin, J., & Chen, D. J. (2002) · Genes & Development · doi:10.1101/gad.1015202 · Cited by 479 · see citing works

Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

Zhao, Y., Thomas, H. D., Batey, M. A., Cowell, I. G., Richardson, C. J., Griffin, R. J., Calvert, H., Newell, D. R., Smith, G. C. M., & Curtin, N. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4275 · Cited by 447 · see citing works

Dual Roles of PARP-1 Promote Cancer Growth and Progression

Schiewer, M. J., Goodwin, J. F., Han, S., Brenner, J. C., Augello, M. A., Dean, J. L., Liu, F., Planck, J. L., Ravindranathan, P., Chinnaiyan, A. M., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0120 · Cited by 443 · see citing works

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.010 · Cited by 414 · see citing works

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

Ferguson, B. J., Mansur, D. S., Peters, N., Ren, H., & Smith, G. L. (2012) · eLife · doi:10.7554/elife.00047 · Cited by 406 · see citing works

Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

Lukas, C., Melander, F., Stucki, M., Falck, J., Bekker‐Jensen, S., Goldberg, M., Lerenthal, Y., Jackson, S. P., Bártek, J., & Lukas, J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600269 · Cited by 387 · see citing works

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

Dvir, A., Peterson, S., Knuth, M. W., Lu, H., & Dynan, W. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11920 · Cited by 371 · see citing works

A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult

Goodwin, J. F., Schiewer, M. J., Dean, J. L., Schrecengost, R. S., de Leeuw, R., Han, S., Ma, T., Den, R. B., Dicker, A. P., Feng, F. Y.-C., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0108 · Cited by 362 · see citing works

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H. K., Drapkin, R., Rickert, P., Lees, E. M., Anderson, C. W., Linn, S., & Reinberg, D. (1996) · Nature · doi:10.1038/381086a0 · Cited by 351 · see citing works

Aberrant Expression of the Transcription Factors Snail and Slug Alters the Response to Genotoxic Stress

Kajita, M., McClinic, K. N., & Wade, P. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7559-7566.2004 · Cited by 334 · see citing works

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

Blier, P. R., Griffith, A. J., Craft, J. E., & Hardin, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53216-6 · Cited by 327 · see citing works

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

O’Brien, T., Hardin, S. E., Greenleaf, A. L., & Lis, J. T. (1994) · Nature · doi:10.1038/370075a0 · Cited by 324 · see citing works

Emerging common themes in regulation of PIKKs and PI3Ks

Lempiäinen, H., & Halazonetis, T. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.281 · Cited by 299 · see citing works

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

Kurimasa, A., Kumano, S., Boubnov, N. V., Story, M. D., Tung, C., Peterson, S., & Chen, D. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3877 · Cited by 298 · see citing works

A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining

van der Burg, M., IJspeert, H., Verkaik, N. S., Turul, T., Wiegant, W. W., Morotomi‐Yano, K., Mari, P., Tezcan, İ., Chen, D. J., Zdzienicka, M. Z., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37141 · Cited by 288 · see citing works

EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment

Liccardi, G., Hartley, J. A., & Hochhauser, D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2384 · Cited by 286 · see citing works

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer

Helgeson, B. E., Tomlins, S. A., Shah, N., Laxman, B., Cao, Q., Prensner, J. R., Cao, X., Singla, N., Montie, J. E., Varambally, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5352 · Cited by 276 · see citing works

Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

Warden, S. M., Richardson, C. A., O’Donnell, J. B., Stapleton, D., Kemp, B. E., & Witters, L. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540275 · Cited by 275 · see citing works

Chapter 2 DNA-PK

Meek, K., Dang, V. D., & Lees‐Miller, S. P. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00602-0 · Cited by 271 · see citing works

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

Liu, S., Opiyo, S. O., Manthey, K. C., Glanzer, J. G., Ashley, A. K., Amerin, C. L., Troksa, K. A., Shrivastav, M., Nickoloff, J. A., & Oakley, G. G. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks849 · Cited by 259 · see citing works

A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin

Wong, R. H.-F., Chang, I., Hudak, C. S. S., Hyun, S., Kwan, H. Y., & Sul, H. S. (2009) · Cell · doi:10.1016/j.cell.2008.12.040 · Cited by 253 · see citing works

DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks

Pankotai, T., Bonhomme, C., Chen, D., & Soutoglou, E. (2012) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2224 · Cited by 239 · see citing works

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

Dobbs, T. A., Tainer, J. A., & Lees‐Miller, S. P. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.019 · Cited by 231 · see citing works

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

Yoo, S. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.24.4679 · Cited by 228 · see citing works

Radiation-induced genomic instability and its implications for radiation carcinogenesis

Huang, L., Snyder, A. R., & Morgan, W. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206697 · Cited by 220 · see citing works

The Dynamics of Histone H1 Function in Chromatin

Bustin, M., Catez, F., & Lim, J.-H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.019 · Cited by 220 · see citing works

ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells

Zong, Y., Xin, L., Goldstein, A. S., Lawson, D. A., Teitell, M. A., & Witte, O. N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905931106 · Cited by 203 · see citing works

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

DOUGLAS, P., Sapkota, G. P., MORRICE, N. A., Yu, Y., Goodarzi, A. A., Merkle, D., Meek, K., Alessi, D. R., & Lees‐Miller, S. P. (2002) · Biochemical Journal · doi:10.1042/bj20020973 · Cited by 196 · see citing works

Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

Warden, S. M., RICHARDSON, C., O’Donnell, J. B., et al. (2001) · Biochemical Journal · doi:10.1042/bj3540275 · Cited by 195 · see citing works

trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining

Meek, K., Douglas, P., Cui, X., Ding, Q., & Lees‐Miller, S. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02366-06 · Cited by 193 · see citing works

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

Toulany, M., Kehlbach, R., Florczak, U., Sak, A., Wang, S., Chen, J., Löbrich, M., & Rodemann, H. P. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2200 · Cited by 186 · see citing works

Akt Promotes Post-Irradiation Survival of Human Tumor Cells through Initiation, Progression, and Termination of DNA-PKcs–Dependent DNA Double-Strand Break Repair

Toulany, M., Lee, K. J., Fattah, K. R., Lin, Y., Fehrenbacher, B., Schaller, M., Chen, B. P., Chen, D. J., & Rodemann, H. P. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0592 · Cited by 183 · see citing works

Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer

Hosoi, Y., Watanabe, T., Nakagawa, K., et al. (2004) · International Journal of Oncology · doi:10.3892/ijo.25.2.461 · Cited by 176 · see citing works

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86

Beskow, C., Skikuniene, J., Holgersson, Å., Nilsson, B. R., Lewensohn, R., Kanter, L., & Viktorsson, K. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605201 · Cited by 170 · see citing works

Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining

Wang, C., & Lees‐Miller, S. P. (2013) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2013.01.011 · Cited by 163 · see citing works

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

An, J., Huang, Y.-C., Xu, Q.-Z., Zhou, L.-J., Shang, Z., Huang, B., Wang, Y., Liu, X.-D., Wu, D.-C., & Zhou, P. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-18 · Cited by 163 · see citing works

Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates γ-H2AX

Douglas, P., Zhong, J., Ye, R., Moorhead, G. B. G., Xu, X., & Lees‐Miller, S. P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00741-09 · Cited by 159 · see citing works

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond

Davidson, D. L., Amrein, L., Panasci, L., & Aloyz, R. S. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00005 · Cited by 156 · see citing works

The DNA-Dependent Protein Kinase Interacts with DNA To Form a Protein−DNA Complex That Is Disrupted by Phosphorylation

Merkle, D., Douglas, P., Moorhead, G. B. G., Leonenko, Z., Yu, Y., Cramb, D. T., Bazett‐Jones, D. P., & Lees‐Miller, S. P. (2002) · Biochemistry · doi:10.1021/bi0263558 · Cited by 155 · see citing works

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells

Delacôte, F. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf452 · Cited by 148 · see citing works

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

Jhappan, C., Morse, H. C., Fleischmann, R. D., Gottesman, M. M., & Merlino, G. T. (1997) · Nature Genetics · doi:10.1038/ng1297-483 · Cited by 144 · see citing works

Choosing the right path: Does DNA-PK help make the decision?

Neal, J. A., & Meek, K. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.010 · Cited by 143 · see citing works

Aire and T cell development

Anderson, M. S., & Su, M. A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.11.007 · Cited by 143 · see citing works

Synthetic lethality between mutation in Atm and DNA-PK cs during murine embryogenesis

Gurley, K. E., & Kemp, C. J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00048-3 · Cited by 142 · see citing works

Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation

Neal, J. A., Dang, V. D., Douglas, P., Wold, M. S., Lees‐Miller, S. P., & Meek, K. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01298-10 · Cited by 141 · see citing works

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

Ni, X., Zhang, Y., Ribas, J., Chowdhury, W. H., Castanares, M. A., Zhang, Z., Laiho, M., DeWeese, T. L., & Lupold, S. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45109 · Cited by 139 · see citing works

Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

Chen, F., Nastasi, A. J., Shen, Z., Brenneman, M. A., Crissman, H. A., & Chen, D. J. (1997) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(97)00020-7 · Cited by 131 · see citing works

Up‐regulation of DNA‐dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma

Shintani, S., Mihara, M., Li, C., et al. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01372.x · Cited by 129 · see citing works

The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain

Douglas, P., Cui, X., Block, W. D., Yu, Y., Gupta, S., Ding, Q., Ye, R., MORRICE, N. A., Lees‐Miller, S. P., & Meek, K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01962-06 · Cited by 127 · see citing works

Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics

Foulds, C. E., Feng, Q. F., Chen, D., Bailey, S., Hunsaker, T. L., Malovannaya, A., Hamilton, R. A., Gates, L. A., Zhang, Z., Li, C., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.007 · Cited by 119 · see citing works

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

Fraser, M. E., Harding, S. M., Zhao, H. W., Coackley, C. L., Durocher, D., & Bristow, R. G. (2011) · Cell Cycle · doi:10.4161/cc.10.13.16305 · Cited by 116 · see citing works

Use of γH2AX and Other Biomarkers of Double-Strand Breaks During Radiotherapy

Sak, A., & Stuschke, M. (2010) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2010.05.004 · Cited by 113 · see citing works

Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21

Block, W. D. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh265 · Cited by 109 · see citing works

The RNA Binding Protein Nuclear Factor 90 Functions as Both a Positive and Negative Regulator of Gene Expression in Mammalian Cells

Reichman, T., Muñiz, L. C., & Mathews, M. B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.343-356.2002 · Cited by 109 · see citing works

Three-Dimensional Structure and Regulation of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs)

Rivera-Calzada, Á., Maman, J. P., Spagnolo, L., Pearl, L. H., & Llorca, Ó. (2005) · Structure · doi:10.1016/j.str.2004.12.006 · Cited by 107 · see citing works

Visualization of a DNA-PK/PARP1 complex

Spagnolo, L., Barbeau, J., Curtin, N. J., Morris, E. P., & Pearl, L. H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1231 · Cited by 104 · see citing works

Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM -Defective Tumors

Riabinska, A., Daheim, M., Herter-Sprie, G. S., Winkler, J., Fritz, C., Hallek, M. J., Thomas, R. K., Kreuzer, K., Frenzel, L. P., Monfared, P., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005814 · Cited by 99 · see citing works

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment.

Hsu, F., Zhang, S., & Chen, B. P. C. (2012) · PubMed · doi:10.3978/j.issn.2218-676x.2012.04.01 · Cited by 98 · see citing works

DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia

Willmore, E., Elliott, S. L., Mainou‐Fowler, T., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5158 · Cited by 94 · see citing works

Activation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6

Mi, J., Dziegielewski, J., Bolesta, E., Brautigan, D. L., & Larner, J. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004395 · Cited by 89 · see citing works

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia

Bouquet, F., Ousset, M., Biard, D. S. F., Fallone, F., Dauvillier, S., Frit, P., Salles, B., & Muller, C. (2011) · Journal of Cell Science · doi:10.1242/jcs.078030 · Cited by 88 · see citing works

Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis

Lee, K. J., Lin, Y., Chou, H.-Y., Yajima, H., Fattah, K. R., Lee, S.-C., & Chen, B. P. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.212969 · Cited by 82 · see citing works

Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase

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DNA-PKcs Expression Predicts Response to Radiotherapy in Prostate Cancer

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Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

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DNA-dependent Protein Kinase-independent Activation of p53 in Response to DNA Damage

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A Functional Cancer Genomics Screen Identifies a Druggable Synthetic Lethal Interaction between MSH3 and PRKDC

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Prognostic significance of ataxia‐telangiectasia mutated, DNA‐dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86‐kD subunit expression in patients with nonsmall cell lung cancer

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Downregulation of protein kinase CK2 induces autophagic cell death through modulation of the mTOR and MAPK signaling pathways in human glioblastoma cells

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The NF90/NF45 Complex Participates in DNA Break Repair via Nonhomologous End Joining

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Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays

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Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage

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DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

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Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium

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Interaction of the Double-Strand Break Repair Kinase DNA-PK and Estrogen Receptor-α

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Emerging roles of DNA-PK besides DNA repair

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Phosphorylation of p50 NF-κB at a Single Serine Residue by DNA-dependent Protein Kinase Is Critical for VCAM-1 Expression upon TNF Treatment

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Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells

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Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription

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Activated Akt expression has significant correlation with EGFR and TGF-alpha expressions in stage I NSCLC.

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Unmodified Histone H3K4 and DNA-Dependent Protein Kinase Recruit Autoimmune Regulator to Target Genes

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Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade

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The N-terminal Region of the DNA-dependent Protein Kinase Catalytic Subunit Is Required for Its DNA Double-stranded Break-mediated Activation

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HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia

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PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase

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Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics

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Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation

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N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku

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p53 Ser15 phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

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DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression

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Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation

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Transcriptional activation of DNA‐dependent protein kinase catalytic subunit gene expression by oestrogen receptor‐α

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DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

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A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation

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DNA‐PKcs Interacts with Aire and Regulates the Expression of Toll‐Like Receptors in RAW264.7 Cells

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Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

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Manumycin polyketides act as molecular glues between UBR7 and P53

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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity

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The role of progesterone-induced blocking factor (PIBF) in invasion of primary ovarian tumour cells

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Cellular Responses to DNA Damage

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DNA damage repair and cardiovascular diseases

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Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

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Interplay between DNA repair and inflammation, and the link to cancer

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