The DOI matches its Crossref record; 183 of the 186 references it cites were found in a registry or an index.
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
Open accessAbstract
Most tumors display oncogene-driven reprogramming of several metabolic pathways, which are crucial to sustain their growth and proliferation. In recent years, both dietary and pharmacologic approaches that target deregulated tumor metabolism are beginning to be considered for clinical applications. Dietary interventions exploit the ability of nutrient-restricted conditions to exert broad biological effects, protecting normal cells, organs, and systems, while sensitizing a wide variety of cancer cells to cytotoxic therapies. On the other hand, drugs targeting enzymes or metabolites of crucial metabolic pathways can be highly specific and effective, but must be matched with a responsive tumor, which might rapidly adapt. In this review, we illustrate how dietary and pharmacologic therapies differ in their effect on tumor growth, proliferation, and metabolism and discuss the available preclinical and clinical evidence in favor of or against each of them. We also indicate, when appropriate, how to optimize future investigations on metabolic therapies on the basis of tumor- and patient-related characteristics. Significance: To our knowledge, this is the first review article that comprehensively analyzes the preclinical and preliminary clinical experimental foundations of both dietary and pharmacologic metabolic interventions in cancer therapy. Among several promising therapies, we propose treatment personalization on the basis of tumor genetics, tumor metabolism, and patient systemic metabolism.Cancer Discov; 6(12); 1315–33. ©2016 AACR.
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“recent studies show that personalized analysis and tailoring of metabolism open up therapeutic possibilities”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [316]
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Zou, Y., Palte, M. J., Deik, A. A., Li, H., Eaton, J. K., Wang, W., Tseng, Y.-Y., Deasy, R., Kost-Alimova, M., Dančík, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09277-9 · Cited by 887
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
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Metabolomics in cancer research and emerging applications in clinical oncology
Schmidt, D. R., Patel, R., Kirsch, D. G., Lewis, C. A., Heiden, M. G. V., & Locasale, J. W. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21670 · Cited by 675
Metadata
- Authors
- Vernieri, C., Casola, S., Foiani, M., Pietrantonio, F., de Braud, F., & Longo, V.
- Affiliations
- IFOM (IT)
- University of Milan (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Southern California (US)
- Corresponding author
- Vernieri, Claudio
- Longo, Valter
- ORCID
- Venue
- Cancer Discovery
- Published
- 2016-12-01
- Volume
- 6
- Issue
- 12
- Pages
- 1315-1333
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC5140697
- OpenAlex
- W2554098255
- Cited by
- 202
- References
- 186
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 22 · 2023: 18 · 2022: 20 · 2021: 24 · 2020: 28 · 2019: 20 · 2018: 21 · 2017: 12
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- National Institute on Aging (P01AG034906)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- cancer metabolism, tumor metabolic reprogramming, dietary intervention, nutrient restriction, metabolic therapy, personalized treatment, cancer genetics, drug resistance
- MeSH terms
- Antineoplastic Agents, Cell Survival, Combined Modality Therapy, Diet Therapy, Humans, Neoplasms, Cell Proliferation, Metabolic Networks and Pathways, Precision Medicine
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