Cited by 202Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

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Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

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Vernieri, Claudio, Casola, Stefano, Foiani, Marco, Pietrantonio, Filippo, de Braud, Filippo, Longo, Valter·2016·Cancer Discovery

DOI 10.1158/2159-8290.cd-16-0615PMC PMC5140697

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Abstract

Most tumors display oncogene-driven reprogramming of several metabolic pathways, which are crucial to sustain their growth and proliferation. In recent years, both dietary and pharmacologic approaches that target deregulated tumor metabolism are beginning to be considered for clinical applications. Dietary interventions exploit the ability of nutrient-restricted conditions to exert broad biological effects, protecting normal cells, organs, and systems, while sensitizing a wide variety of cancer cells to cytotoxic therapies. On the other hand, drugs targeting enzymes or metabolites of crucial metabolic pathways can be highly specific and effective, but must be matched with a responsive tumor, which might rapidly adapt. In this review, we illustrate how dietary and pharmacologic therapies differ in their effect on tumor growth, proliferation, and metabolism and discuss the available preclinical and clinical evidence in favor of or against each of them. We also indicate, when appropriate, how to optimize future investigations on metabolic therapies on the basis of tumor- and patient-related characteristics. Significance: To our knowledge, this is the first review article that comprehensively analyzes the preclinical and preliminary clinical experimental foundations of both dietary and pharmacologic metabolic interventions in cancer therapy. Among several promising therapies, we propose treatment personalization on the basis of tumor genetics, tumor metabolism, and patient systemic metabolism.Cancer Discov; 6(12); 1315–33. ©2016 AACR.

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Authors: Vernieri, C., Casola, S., Foiani, M., Pietrantonio, F., de Braud, F., & Longo, V.
Affiliations: IFOM (IT)
University of Milan (IT)
Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
University of Southern California (US)
Corresponding author: Vernieri, Claudio
Longo, Valter
ORCID: Vernieri, Claudio
Casola, Stefano
Foiani, Marco
Pietrantonio, Filippo
de Braud, Filippo
Longo, Valter
Venue: Cancer Discovery
Publisher: American Association for Cancer Research (AACR)
Published: 2016-12-01
Volume: 6
Issue: 12
Pages: 1315-1333
ISSN: 2159-8274 (ISSN-L)
2159-8290
DOI: 10.1158/2159-8290.cd-16-0615
PMC: PMC5140697
OpenAlex: W2554098255
Cited by: 202
References: 186
Citations by year: 2026: 16 · 2025: 21 · 2024: 22 · 2023: 18 · 2022: 20 · 2021: 24 · 2020: 28 · 2019: 20 · 2018: 21 · 2017: 12
FWCI: 1.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Discovery (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Funders: National Institute on Aging (P01AG034906)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: cancer metabolism, tumor metabolic reprogramming, dietary intervention, nutrient restriction, metabolic therapy, personalized treatment, cancer genetics, drug resistance
MeSH terms: Antineoplastic Agents, Cell Survival, Combined Modality Therapy, Diet Therapy, Humans, Neoplasms, Cell Proliferation, Metabolic Networks and Pathways, Precision Medicine

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