The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma
Open accessPublished version of a preprint
Abstract
PD-1 immune checkpoint inhibitors have produced encouraging results in patients with hepatocellular carcinoma (HCC). However, what determines resistance to anti–PD-1 therapies is unclear. We created a novel genetically engineered mouse model of HCC that enables interrogation of how different genetic alterations affect immune surveillance and response to immunotherapies. Expression of exogenous antigens in MYC;Trp53−/− HCCs led to T cell–mediated immune surveillance, which was accompanied by decreased tumor formation and increased survival. Some antigen-expressing MYC;Trp53−/− HCCs escaped the immune system by upregulating the β-catenin (CTNNB1) pathway. Accordingly, expression of exogenous antigens in MYC;CTNNB1 HCCs had no effect, demonstrating that β-catenin promoted immune escape, which involved defective recruitment of dendritic cells and consequently impaired T-cell activity. Expression of chemokine CCL5 in antigen-expressing MYC;CTNNB1 HCCs restored immune surveillance. Finally, β-catenin–driven tumors were resistant to anti–PD-1. In summary, β-catenin activation promotes immune escape and resistance to anti–PD-1 and could represent a novel biomarker for HCC patient exclusion. Significance: Determinants of response to anti–PD-1 immunotherapies in HCC are poorly understood. Using a novel mouse model of HCC, we show that β-catenin activation promotes immune evasion and resistance to anti–PD-1 therapy and could potentially represent a novel biomarker for HCC patient exclusion. See related commentary by Berraondo et al., p. 1003. This article is highlighted in the In This Issue feature, p. 983
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In a mouse model of HCC, activation of WNT–β-catenin signalling promotes immune escape by impairing recruitment of dendritic cells and interfering with recognition by natural killer cells73.”
From Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma (2024) · cites this paper as [73]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320
Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097
Self-citationSafety, activity, and immune correlates of anti–PD-1 antibody in cancer
Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406
Self-citationPD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 928
Zhang, Y., Yang, J., Shao, T., Chen, J., Shu, Q., & Shou, L. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2313281 · Cited by 1
Li, S., Xu, Y., Hu, X., Chen, H., Xi, X., Long, F., Rong, Y., Wang, J., Yuan, C., Chen, L., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109901 · Cited by 1
TLK2 promotes progression of hepatocellular carcinoma through Wnt/β-catenin signaling
He, T., Xu, B., & Ma, H. (2024) · Translational Cancer Research · doi:10.21037/tcr-23-2264 · Cited by 1
Immunotherapeutic strategies in hepatopancreatobiliary cancers
Salati, M., Rizzo, A., Ricci, A. D., Petrillo, A., & Parisi, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13376-3.00014-9 · Cited by 1
Naganuma, A., Kakizaki, S., Hiraoka, A., Tada, T., Hatanaka, T., Kariyama, K., Tani, J., Atsukawa, M., Takaguchi, K., Itobayashi, E., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.70618 · Cited by 1
Li, S., Guo, W., Qian, Y., Li, L., Li, Q., Zhu, Z., Qin, W., Li, W., Yuan, Y., Gao, W., et al. (2025) · Open Research (University of Surrey) · doi:10.1002/viw.20250036 · Cited by 3
Tumor Evolution Driving Genome Instability, Immune Interactions, and Response to Radiotherapy
Seed, G., Truong, F., Riahi, R., & O’Leary, B. (2025) · The Cancer Journal · doi:10.1097/ppo.0000000000000777 · Cited by 2
Liu, J., Xiong, S., Zhao, Y., Yang, X., Shen, J., He, Z., Zhang, Y., Zhang, Y., Guo, L., & Liang, T. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117229 · Cited by 4
Zhang, Y., Li, H., Jiang, N., & Ru, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1626251 · Cited by 2
Kim, S. H. (2025) · Cancers · doi:10.3390/cancers17223671 · Cited by 2
Yu, H., Wu, J., & Gao, L. (2025) · BMC Cancer · doi:10.1186/s12885-025-15429-6 · Cited by 1
WNT-Driven Immune Evasion Promotes Malignant Transformation of BRAF-Mutant Colorectal Cancer
Mastel, M., Martinez, A. G., Pozza, U., Meier, J., Chiotakakos, I., Jaun, S., Artmann, C., Diamante, G., Georgakopoulos, N., Albrecht, P., et al. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.07.035 · Cited by 1
Li, Z., Xiong, M., Xiang, Y., Yang, G., & Xiong, Y. (2026) · World Journal of Surgical Oncology · doi:10.1186/s12957-026-04198-6 · Cited by 1
Xie, X., Pu, L., Zeng, J., Xu, M., Yin, X., Liu, H., Yang, J., Cao, J., & Song, H. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151166 · Cited by 1
Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer
Montoya, T., Lee, J. V., Qiu, L., Krall, A., Matulionis, N., Seo, Y., Finck, B. N., Kelley, R. K., Christofk, H. R., & Goga, A. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117107 · Cited by 1
Nomiya, H., Matsuda, H., Nosaka, T., Akazawa, Y., Tanaka, T., Takahashi, K., Naito, T., Ohtani, M., Imamura, Y., & Nakamoto, Y. (2026) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-025-02266-0 · Cited by 1
Rewiring immunity: Midkine’s emerging role in cancer immune escape and drug resistance
Saikia, M., Prem, S., & Kapoor, V. (2026) · iScience · doi:10.1016/j.isci.2026.115497 · Cited by 1
Li, K. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1811918 · Cited by 1
Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications
Fang, J., Ling, J., Liu, X., Wang, Y., Huang, Y., Cao, Z., 邹燕梅, & Xiong, H. (2026) · Amino Acids · doi:10.1007/s00726-026-03517-1 · Cited by 1
Sorop, A., Ghionescu, A.-V., Ancuța, D.-L., Croitoru, M.-G., Coman, C., Lixandru, D., & Dima, S. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1805025 · Cited by 1
Zhang, W., Liang, S., Han, S., Zha, Q., Sun, L., Tao, S., Zhang, Y., Chu, J., Chu, Q., Zhang, N., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72814-w · Cited by 2
Targeting SMYD2 improves immunotherapy response in experimental hepatocellular carcinoma
Bueloni, B., Fusco, M., Fiore, E. J., Malvicini, M., Cantero, M. J., Mauriz, L. L., Casadei, M., Ruiz, B. M., Mercogliano, M. F., Santamaría, E., et al. (2026) · Molecular Therapy Oncology · doi:10.1016/j.omton.2026.201239 · Cited by 2
Bile acid retention impairs tumoral antigen presentation and intrinsic tumor suppression in MASH-HCC
Wei, W., Zhang, Z., Zhao, X., Duan, J., Ma, J., Deng, S., Liu, Y., Sun, L., & Wang, J. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218589 · Cited by 1
Bayram, E., Broggi, G., & Ayan, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125201 · Cited by 1
Yuza, K., & Pawlik, T. M. (2026) · Cells · doi:10.3390/cells15121097 · Cited by 1
Tan, J., Wen, T., Liu, J. S., & Ru, X. (2026) · Journal of Hematology & Oncology · doi:10.1186/s13045-026-01828-0 · Cited by 1
Ragland, S. A., Lindblad, K. E., Li, Y., Choi, J. H., Okin, D. A., Mao, J. Q., Richmond-Buccola, D., Coronado, D. R., Brown, M. R., Snapper, S. B., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.06.023 · Cited by 1
Self-citationTNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment
Bolaños, E., Cañas‐Zabala, L., Olivera, I., Ruiz-Guillamon, D., Vercher, E., Gomis, G., de Andrea, C. E., Alexandru, R., Azpilikueta, A., Soria, N., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20252080 · Cited by 1
Shan, X., Zhang, M., Lin, H., Zhu, M., & Li, M. (2021) · Trends in Oncology · doi:10.37155/2717-5278-2021-03-02-1 · Cited by 1
Zhi, W., Hou, J., Fan, S., & Yue, H. (2022) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_732_22 · Cited by 1
Systemic treatment for unresectable hepatocellular carcinoma
Leowattana, W., Leowattana, T., & Leowattana, P. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i10.1407 · Cited by 2
Gong, H., Xie, H., Huangfu, Z., Zhang, S., Tang, Y., Xiao, M., Li, M., & Wang, Y. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13598 · Cited by 1
Hydrodynamic Transfection of Hepatocytes for the Study of Hepatocellular Carcinogenesis
Bedoya, J. U., & Grégoire, D. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3694-7_6 · Cited by 1
Giannini, E. G. (2024) · Digestive and Liver Disease · doi:10.1016/j.dld.2024.08.051 · Cited by 1
Cao, Y.-Z., Pan, J.-Y., Zheng, G.-L., An, C., & Zuo, M. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03872-6 · Cited by 2
Wang, X., Liu, D., Wang, S., & He, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1534611 · Cited by 1
Self-citationChen, L., Li, Y., Zhang, Z., Yang, T., & Zeng, H. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1591165 · Cited by 2
DiMarco, A. V., & Maddalo, D. (2022) · Current Protocols · doi:10.1002/cpz1.377 · Cited by 2
Predictors of response for hepatocellular carcinoma immunotherapy: is there anything on the horizon?
Rizzo, A., & Ricci, A. D. (2022) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2022.2075724 · Cited by 1
Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture modelPreprint
Suter, P., Dazert, E., Kuipers, J., Ng, C. K. Y., Boldanova, T., Hall, M. N., Heim, M. H., & Beerenwinkel, N. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.16.473083 · Cited by 2
Hepatocellular carcinoma treatments: A new hope, but a headache for clinicians and researchers
Saltel, F., & Blanc, J. (2022) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2022.101927 · Cited by 1
Vansant-Webb, C. H., Low, H. K., Kuramoto, J., Stanley, C. E., Qiang, H., Su, A. Y., Ross, A. N., Cooper, C. G., Cox, J. E., Summers, S. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.12.562134 · Cited by 1
Krishna, A., Meynert, A. M., Kelder, M. J. E., Ewing, A., Sheraz, S., Ferrer‐Vaquer, A., Grimes, G. R., Becher, H., Silk, R., Semple, C. A. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.09.566307 · Cited by 1
Dantzer, C., Vaché, J., Brunel, A., Mahouche, I., Raymond, A., Dupuy, J., Petrel, M., Bioulac‐Sage, P., Perrais, D., Dugot‐Senant, N., et al. (2023) · eLife · doi:10.1101/2023.10.24.563805 · Cited by 1
Fournier, C., Mercey-Ressejac, M., Dérangère, V., Kadi, A. A., Rageot, D., Charrat, C., Leroy, A., Escudé, M., Escaich, S., Ghiringhelli, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.24.604918 · Cited by 1
NOTCH1 drives tumor plasticity and metastasis in hepatocellular carcinomaPreprint
Lindblad, K. E., Donné, R., Liebling, I., Bresnahan, E. R., Bárcena‐Varela, M., Lozano, A., Park, E. Y. H., Giotti, B., Burn, O. K., Fiel, M. I., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.23.619856 · Cited by 1
Self-citationHu, H.-H., Wang, X., Lan, B., Cheng, H., Wen, H. M., Chen, F., Wu, J., Li, M., Chen, J., Chen, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.16.628539 · Cited by 1
Differentiation status determines tumorigenicity and immunogenicity of cancer cellsPreprint
Liu, Y., Wang, C., Li, H., & Cao, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.30.656250 · Cited by 1
Hepatobiliary Cancers and Immunology
Kodama, T., & Takehara, T. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_31
Immune Checkpoint Inhibitors in Gastrointestinal Malignancies
Padmaraju, V., & Rao, M. R. M. (2020) · Diagnostics and therapeutic advances in GI malignancies · doi:10.1007/978-981-15-6487-1_6
Zhao, H., Chen, C., & He, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99836
ZiYi, G., LiPeng, J., & Zhu, Z. (2021) · Research Square · doi:10.21203/rs.3.rs-203679/v1
NAFLD Indirectly Impairs Antigen Specific CD8 + T Cell Immunity Against Liver Cancer in MicePreprint
McVey, J. C., Green, B. L., Ruf, B., McCallen, J., Wabitsch, S., Subramanyam, V., Diggs, L. P., Heinrich, B., Greten, T. F., & Ma, C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3924630
Chen, G., Zhang, C., Li, D., Luo, D., Liao, H., Huang, P., Wang, N., & Feng, Y. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4050066
Precision medicine approaches for treating hepatocellular carcinoma
Ahmed, N., Benny, K., Siraj, S., Ali, H., & Basha, R. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99283-1.00002-1
β-Catenin Is a Novel Target in YES-associated Protein-driven Cholangiocarcinoma
Lozano, A., & Lujambio, A. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.05.047
Self-citationβ-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expressionPreprint
Suzuki, T., Kilbey, A., Ridgway, R. A., Hayman, H., Bryne, R., Casa-Rodríguez, N., Γεωργακοπούλου, Α., Chen, L., Verzi, M. P., Gay, D. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.10.495115
Chen, Z., Soni, N., Piñero, G., Giotti, B., Eddins, D. J., Lindblad, K. E., Ross, J., Tsankova, N. M., Gutmann, D. H., Lira, S. A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.21.500690
Self-citationAdvanced HCC precision modeling reveals divergent responses to combinatorial immunotherapyPreprint
Liu, J., Cheng, L., El‐Mekkoussi, H., Lee, M., Jaffe, D. R., Gavin-Darby, K., Morgan, A. R., Manduchi, E., Schug, J., & Kaestner, K. H. (2022) · Research Square · doi:10.21203/rs.3.rs-1919053/v1
The Immune System in Liver Cancer: From Beginning to Progression
Silva, A. J. D. M., Gama, J. E. D. M., do Nascimento, C. M., Lucena, J. P., da Costa, C. J., Fernandes, C. J. B., Moura, D. M. N., Carvalho, H., & de Oliveira, S. A. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_37
Ni, J., Liu, L., Wu, P., Zhu, X., & Xu, C. (2023) · Research Square · doi:10.21203/rs.3.rs-2549184/v1
Immunotherapy in Gastrointestinal Malignancies
Uğraklı, M., Karaağaç, M., & Artaç, M. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_218-1
Teijeira, Á., Garasa, S., Luri‐Rey, C., de Andrea, C., Gato, M., Molina, C., Kaisho, T., Cirella, A., Azpilikueta, A., Wculek, S. K., et al. (2023) · doi:10.1158/0008-5472.c.6514338.v1
Esteban-Fabró, R., Willoughby, C. E., Piqué‐Gili, M., Montironi, C., Abril‐Fornaguera, J., Peix, J., Torrens, L., Mesropian, A., Balaseviciute, U., Miró‐Mur, F., et al. (2023) · doi:10.1158/1078-0432.22482765.v1
Self-citationEsteban-Fabró, R., Willoughby, C. E., Piqué‐Gili, M., Montironi, C., Abril‐Fornaguera, J., Peix, J., Torrens, L., Mesropian, A., Balaseviciute, U., Miró‐Mur, F., et al. (2023) · doi:10.1158/1078-0432.c.6530994
Self-citationEsteban-Fabró, R., Willoughby, C. E., Piqué‐Gili, M., Montironi, C., Abril‐Fornaguera, J., Peix, J., Torrens, L., Mesropian, A., Balaseviciute, U., Miró‐Mur, F., et al. (2023) · doi:10.1158/1078-0432.c.6530994.v1
Self-citationYoon, S. J., Combs, J. A., Falzone, A., Prieto-Farigua, N., Caldwell, S., Ackerman, H. D., Flores, E. R., & DeNicola, G. M. (2023) · doi:10.1158/0008-5472.c.6626136
SLC25A24, a potential and novel biomarker for diagnosing colorectal cancerPreprint
Xu, H., Liu, Y., Liu, S., An, Q., Cao, H., Fan, X., & Jiang, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-2943350/v1
Schafer, C. C., Jiang, J., Elsamanoudi, S. I., Nousome, D., Young, D., Song, Y., Sesterhenn, I. A., Chesnut, G. T., & Tan, S. (2023) · doi:10.1158/2767-9764.c.6734431.v1
Wu, D., Feng, B., Su, W. C., Xiong, W., Xu, M., Xu, A., Fu, B., & Li, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-3165133/v1
RetractedLi, R., Ding, Z., Meng, G.-X., Liu, H., Xue, J.-S., Yan, L., Dong, Z., Hong, J., Chen, Z., Tian, B., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3226964/v1
Feng, Z., Wang, Y., Liang, Y., Gu, X., Yang, Y., Zhang, Y., & Peng, Q. (2023) · Research Square · doi:10.21203/rs.3.rs-3153345/v1
Amino Acids Transport as an Index of Cancer Stem Cells Dysregulation
Ortega, A., & Najimi, M. (2023) · Springer eBooks · doi:10.1007/978-981-99-0846-2_61-1
Song, F., & Chen, Z. (2023) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v31.i24.989
Raghav, A., & Goo-Bo-Jeong (2024) · Engineering materials · doi:10.1007/978-981-99-8010-9_12
Katô, K., Noda, T., Kobayashi, S., Yamanaka, C., Sasaki, K., Iwagami, Y., Yamada, D., Tomimaru, Y., Takahashi, H., Asaoka, T., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4146276/v1
Ortiz-Barahona, V., Soler, M., Dávalos, V., García-Prieto, C. A., Janin, M., Setién, F., Fernández-Rebollo, I., Bech‐Serra, J. J., de la Torre, C., Guil, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22814990
Self-citationNing, Y., Lin, K., Liu, X., Ding, Y., Jiang, X. W., Zhang, Z., Xuan, Y.-T., Li, D., Liu, L., Wang, F., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20522679
Ortiz-Barahona, V., Soler, M., Dávalos, V., García-Prieto, C. A., Janin, M., Setién, F., Fernández-Rebollo, I., Bech‐Serra, J. J., de la Torre, C., Guil, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22815008
Self-citationOrtiz-Barahona, V., Soler, M., Dávalos, V., García-Prieto, C. A., Janin, M., Setién, F., Fernández-Rebollo, I., Bech‐Serra, J. J., de la Torre, C., Guil, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22815011
Self-citationOrtiz-Barahona, V., Soler, M., Dávalos, V., García-Prieto, C. A., Janin, M., Setién, F., Fernández-Rebollo, I., Bech‐Serra, J. J., de la Torre, C., Guil, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22815014
Self-citationOrtiz-Barahona, V., Soler, M., Dávalos, V., García-Prieto, C. A., Janin, M., Setién, F., Fernández-Rebollo, I., Bech‐Serra, J. J., de la Torre, C., Guil, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22815017
Self-citationChen, H., Li, Z., Wang, M., Lu, L., Tang, Q., & Luo, L. (2024) · PubMed Central · doi:10.12122/j.issn.1673-4254.2024.03.06
Katô, K., Noda, T., Kobayashi, S., Yamanaka, C., Sasaki, K., Iwagami, Y., Yamada, D., Tomimaru, Y., Takahashi, H., Asaoka, T., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4239792/v1
Prognostic role of YBX1 and its correlation with immune infiltrates in Hepatocellular CarcinomaPreprint
Yang, X., Huang, H., Fan, J., Zheng, D. I., Wang, R., Zhou, X., Li, B., & Peng, T. (2024) · Research Square · doi:10.21203/rs.3.rs-4410483/v1
Amino Acids Transport as an Index of Cancer Stem Cells Dysregulation
Ortega, A., & Najimi, M. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_61
Recent Advances in Immune-based Therapy for Hepatocellular Carcinoma
Park, K. W., Park, T. H., Jang, E. J., & Sung, P. S. (2024) · Journal of Digestive Cancer Research · doi:10.52927/jdcr.2024.12.2.115
ICOS limits memory-like properties and function of exhausted PD-1 + CD8 T cellsPreprint
Humblin, É., Korpas, I., Prokhnevska, N., Vaidya, A. B., Lu, J., van der Heide, V., Filipescu, D., Bobrowski, T., Marks, A. R., Park, M. D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.16.611518
Self-citationWu, H., Shu, W., Ding, Y., Li, Q., Li, N., Wang, Q., Chen, Y., Han, Y., Huang, D., & Jiang, H. (2024) · Research Square · doi:10.21203/rs.3.rs-4989092/v1
Feng, Z., Wang, Y., Liang, Y., Gu, X., Yang, Y., Zhang, Y., & Peng, Q. (2024) · Discover Oncology · doi:10.1007/s12672-024-01630-9
Immunotherapy for Gastrointestinal Malignancies
Uğraklı, M., Karaağaç, M., & Artaç, M. (2024) · Springer eBooks · doi:10.1007/978-3-030-80962-1_218-2
A selective TNKS2 inhibitor for tumor-restricted WNT suppression
Zimmerman, J., Malone, B. F., Chu, K., Finkin-Groner, E., 孙姗, Liang, R., Bahadur, S., Foronda, M., Schatoff, E. M., Granowsky, E., et al. (2026) · Nature Chemical Biology · doi:10.1101/2025.03.04.641305 · Cited by 1
Huang, A., Li, T., Zhou, Y., Li, S., Zhang, J., Li, Y., Wu, S., Kong, Y., Yu, Z., & Xia, J. (2025) · Open Research (University of Surrey) · doi:10.1002/viw.20240103
Zhao, F. H., Gong, L., Wang, P., Chen, D., Cao, S., Yang, F., Tang, M., Meng, Y., Wang, Y., Miao, L., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03425-8 · Cited by 5
Cancer cells impede T cell early activation and drive immune evasion by transferring Tmem176bPreprint
Xiao, N., Gao, X., Liu, F., You, A., Jin, Y., Luo, F., Zhang, Q., Lan, Z., Xie, J., Zeng, Q., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6199894/v1
Immunotherapy for Gastrointestinal Malignancies
Uğraklı, M., Karaağaç, M., & Artaç, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-00769-8_218
Muliawan, G. K., & Lee, T. K. (2025) · Hepatology · doi:10.1097/hep.0000000000001619
The Impact of the FXR1-FUBP1 Axis on Chemotherapy Resistance in LUSC Cells
Liang, R., Li, Y., Chen, J.-Y., & Deng, H. (2025) · Biochemical Genetics · doi:10.1007/s10528-025-11290-1
Liang, Z., Zheng, J., Su, Z., Wu, B. Y., Yang, H., Bai, S., Wu, X., Sun, C., Duan, L., Chen, S., et al. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04365-5
Bacteroidetes promote hepatocellular carcinoma progression and resistance to immunotherapyPreprint
Bárcena‐Varela, M., Shang, J., Mogno, I., Lozano, A., Liebling, I., Mead, K. R., Li, Z., Grinspan, L. T., Lindblad, K. E., de Galarreta, M. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.09.693238
Self-citation
Metadata
- Authors
- Ruiz de Galarreta, M., Bresnahan, E., Molina-Sánchez, P., Lindblad, K. E., Maier, B., Sia, D., Puigvehi, M., Miguela, V., Casanova-Acebes, M., Dhainaut, M., Villacorta-Martin, C., Singhi, A. D., Moghe, A., von Felden, J., Tal Grinspan, L., Wang, S., Kamphorst, A. O., Monga, S. P., Brown, B. D., Villanueva, A., Llovet, J. M., Merad, M., & Lujambio, A.
- Affiliations
- 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
- Tisch Cancer Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
- 2Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
- University of Pittsburgh (US)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Lujambio, Amaia
- ORCID
- Ruiz de Galarreta, Marina
- Molina-Sánchez, Pedro
- Lindblad, Katherine E.
- Maier, Barbara
- Sia, Daniela
- Puigvehi, Marc
- Miguela, Verónica
- Casanova-Acebes, María
- Dhainaut, Maxime
- Singhi, Aatur D.
- Moghe, Akshata
- von Felden, Johann
- Wang, Shuang
- Kamphorst, Alice O.
- Monga, Satdarshan P.
- Brown, Brian D.
- Villanueva, Augusto
- Llovet, Josep M.
- Lujambio, Amaia
- Venue
- Cancer Discovery
- Published
- 2019-08-01
- Volume
- 9
- Issue
- 8
- Pages
- 1124-1141
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC6677618
- OpenAlex
- W2952311394
- Cited by
- 912
- References
- 67
- Citations by year
- 2026: 114 · 2025: 121 · 2024: 158 · 2023: 169 · 2022: 156 · 2021: 116 · 2020: 67 · 2019: 11
- FWCI
- 36.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Cancer Discovery (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Damon Runyon Cancer Research FoundationDamon Runyon Cancer Research Foundation (Damon Runyon) (DR52-18)
- HHS | NIH | National Cancer InstituteHHS | NIH | National Cancer Institute (NCI) (R37CA230636, P30 CA196521)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- β-catenin signaling, hepatocellular carcinoma, immune evasion, anti-PD-1 resistance, PD-1 inhibitors, tumor surveillance, c-Myc, Trp53, dendritic cell recruitment, T cell function, RANTES, chemokines, genetically engineered mouse models, immunotherapy biomarkers
- MeSH terms
- Antineoplastic Agents, Immunological, Animals, Dendritic Cells, Disease Models, Animal, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Oncogenes, Biomarkers, Tumor, Signal Transduction, Gene Expression, Treatment Outcome, CD8-Positive T-Lymphocytes, Drug Resistance, Neoplasm, Tumor Escape, Xenograft Model Antitumor Assays, Cell Line, Tumor, beta Catenin, Mice, Programmed Cell Death 1 Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
