A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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The Clinical KRAS(G12C) Inhibitor AMG 510 Drives Anti-Tumour Immunity

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Restoration of p53 function leads to tumour regression in vivo

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PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

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A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

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Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

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Clinical Overview of MDM2/X-Targeted Therapies

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Li-Fraumeni syndrome: cancer risk assessment and clinical management

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GBT 440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

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Systematic Study of the Glutathione (GSH) Reactivity ofN-Arylacrylamides: 1. Effects of Aryl Substitution

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The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors

Hansen, R., Peters, U., Babbar, A., Chen, Y., Feng, J., Janes, M. R., Li, L.-S., Ren, P., Liu, Y., & Zarrinkar, P. P. (2018) · Nature Structural &amp; Molecular Biology · doi:10.1038/s41594-018-0061-5 · Cited by 153 · see citing works

Effects of Common Cancer Mutations on Stability and DNA Binding of Full-length p53 Compared with Isolated Core Domains

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Understanding p53 functions through p53 antibodies

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2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

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p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo

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Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

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Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

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Systematic Study of the Glutathione Reactivity of N ‑Phenylacrylamides: 2. Effects of Acrylamide Substitution

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Small molecule protein binding to correct cellular folding or stabilize the native state against misfolding and aggregation

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Markov state models and NMR uncover an overlooked allosteric loop in p53

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Hypothermia Effectively Treats Tumors with Temperature-Sensitive p53 Mutations

Lu, J., Chen, L., Song, Z., Das, M., & Chen, J. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0033 · Cited by 21 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

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Acetylation targeting chimera enables acetylation of the tumor suppressor p53

Kabir, M., Sun, N., Hu, X., Martin, T. C., Yi, J., Zhong, Y., Xiong, Y., Kaniskan, H. Ü., Gu, W., Parsons, R., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c04640 · Cited by 65 · see citing works

Small-molecule correctors and stabilizers to target p53

Fallatah, M. M. J., Law, F. V., Chow, W. A., & Kaiser, P. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.007 · Cited by 44 · see citing works

Functional investigations of p53 acetylation enabled by heterobifunctional molecules

Chen, L.-Y., Singha Roy, S. J., Jadhav, A. M., Wang, W. W., Chen, P.-H., Bishop, T., Erb, M. A., & Parker, C. G. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00438 · Cited by 18 · see citing works

Are <i>TP53</i> mutations all alike?

Wong, T. N., & Link, D. C. (2024) · Hematology · doi:10.1182/hematology.2024000556 · Cited by 11 · see citing works

Design, synthesis, and evaluation of p53Y220C acetylation targeting chimeras (AceTACs)

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Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

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Photosynthetic and Chlorophyll Fluorescence Characteristics of Xantha Type Rice Mutant

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Developmental properties of induced buds from a nonbudding mutant of Hydra viridis

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Isolation and characterization of a novelArabidopsis thatianamutant that requires a high concentration of boron

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Tumor Suppressor p53: Analysis of Wild-Type and Mutant p53 Complexes

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