The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice
Open accessPublished version of a preprint
Abstract
Pancreatic cancer, one of the deadliest human malignancies, is associated with oncogenic Kras and is most commonly preceded by precursor lesions known as pancreatic intraepithelial neoplasias (PanIN). PanIN formation is accompanied by the establishment of an immunotolerant microenvironment. However, the immune contribution to the initiation of pancreatic cancer is currently poorly understood. Here, we genetically eliminate CD4+ T cells in the iKras* mouse model of pancreatic cancer, in the context of pancreatitis, to determine the functional role of CD4+ T cells during mutant Kras-driven pancreatic carcinogenesis. We show that oncogenic Kras-expressing epithelial cells drive the establishment of an immunosuppressive microenvironment through the recruitment and activity of CD4+ T cells. Furthermore, we show that CD4+ T cells functionally repress the activity of CD8+ T cells. Elimination of CD4+ T cells uncovers the antineoplastic function of CD8+ T cells and blocks the onset of pancreatic carcinogenesis. Thus, our studies uncover essential and opposing roles of immune cells during PanIN formation and provide a rationale to explore immunomodulatory approaches in pancreatic cancer. Cancer Immunol Res; 2(5); 423–35. ©2014 AACR.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Other T cell populations within the TME have all been noted to play protumorigenic roles, including Th17, Th22, CD4, and γδ T cells188–191”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [190]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753
CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
Beatty, G. L., Chiorean, E. G., Fishman, M. P., Saboury, B., Teitelbaum, U. R., Sun, W., Huhn, R. D., Song, W., Li, D., Sharp, L. L., et al. (2011) · Science · doi:10.1126/science.1198443 · Cited by 1,706
Self-citationAdaptive immunity maintains occult cancer in an equilibrium state
Koebel, C. M., Vermi, W., Swann, J. B., Zerafa, N., Rodig, S. J., Old, L. J., Smyth, M. J., & Schreiber, R. D. (2007) · Nature · doi:10.1038/nature06309 · Cited by 1,438
DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,395
Cited by
Sorted by citations
Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer
Steele, N. G., Carpenter, E. S., Kemp, S. B., Sirihorachai, V. R., The, S., Delrosario, L., Lazarus, J., Amir, E.-A. D., Gunchick, V., Espinoza, C. E., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00121-4 · Cited by 556
Self-citationGenetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527
Winograd, R., Byrne, K. T., Evans, R. A., Odorizzi, P. M., Meyer, A. R. L., Bajor, D. L., Clendenin, C., Stanger, B. Z., Furth, E. E., Wherry, E. J., et al. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0215 · Cited by 459
Self-citationTumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance
Sherman, M. H., & Beatty, G. L. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031621-024600 · Cited by 501
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
Hegde, S., Lander, V. E., Herzog, B. H., Zuo, C., Breden, M. A., Knolhoff, B. L., Hogg, G. D., Tang, J. P., Baer, J. M., Mpoy, C., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.02.008 · Cited by 469
Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities
Balachandran, V. P., Beatty, G. L., & Dougan, S. K. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.038 · Cited by 444
Pancreatic cancer biology and genetics from an evolutionary perspective
Makohon-Moore, A. P., & Iacobuzio–Donahue, C. A. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.66 · Cited by 436
Zhang, Y., Lazarus, J., Steele, N. G., Yan, W., Lee, H.-J., Nwosu, Z. C., Halbrook, C. J., Menjivar, R. E., Kemp, S. B., Sirihorachai, V. R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0958 · Cited by 385
Self-citationIL35-Producing B Cells Promote the Development of Pancreatic Neoplasia
Pylayeva‐Gupta, Y., Das, S., Handler, J. S., Hajdu, C. H., Coffre, M., Koralov, S. B., & Bar‐Sagi, D. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0843 · Cited by 367
Manzo, T., Prentice, B. M., Anderson, K. G., Raman, A. T., Schalck, A. P., Codreanu, G. S., Lauson, C. B. N., Tiberti, S., Raimondi, A., Jones, M. A., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191920 · Cited by 347
Zhang, Y., Velez-Delgado, A., Mathew, E., Li, D., Mendez, F., Flannagan, K., Rhim, A. D., Simeone, D. M., Beatty, G. L., & di Magliano, M. P. (2016) · Gut · doi:10.1136/gutjnl-2016-312078 · Cited by 339
Self-citationBeatty, G. L., Winograd, R., Evans, R. A., Long, K. B., Luque, S. L., Lee, J. W., Clendenin, C., Gladney, W. L., Knoblock, D. M., Guirnalda, P. D., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.010 · Cited by 297
Self-citationCurrent and future immunotherapeutic approaches in pancreatic cancer treatment
Farhangnia, P., Khorramdelazad, H., Nickho, H., & Delbandi, A. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01561-6 · Cited by 265
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
Zhang, T., Ren, Y., Yang, P., Wang, J., & Zhou, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05351-1 · Cited by 240
Wu, M., Li, X., Zhang, T., Liu, Z., & Zhao, Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00996 · Cited by 218
Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy
Sharma, N. S., Gupta, V. K., Garrido, V. T., Hadad, R., Durden, B. C., Kesh, K., Giri, B., Ferrantella, A., Dudeja, V., Saluja, A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127515 · Cited by 203
Kemp, S. B., Carpenter, E. S., Steele, N. G., Donahue, K. L., Nwosu, Z. C., Pacheco, A., Velez-Delgado, A., Menjivar, R. E., Lima, F., The, S., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3929 · Cited by 197
Self-citationKRAS-related proteins in pancreatic cancer
Mann, K. M., Ying, H., Juan, J. M., Jenkins, N. A., & Copeland, N. G. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.09.003 · Cited by 192
The biological underpinnings of therapeutic resistance in pancreatic cancerPreprint
Beatty, G. L., Werba, G., Lyssiotis, C. A., & Simeone, D. M. (2021) · Genes & Development · doi:10.1101/gad.348523.121 · Cited by 139
Kenkel, J. A., Tseng, W. W., Davidson, M. G., Tolentino, L. L., Choi, O., Bhattacharya, N., Seeley, E. S., Winer, D. A., Reticker-Flynn, N. E., & Engleman, E. G. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2212 · Cited by 139
Differential contribution of pancreatic fibroblast subsets to the pancreatic cancer stroma
Garcia, P. E., Adoumie, M., Kim, E. C., Zhang, Y., Scales, M. K., El-Tawil, Y. S., Shaikh, A. Z., Wen, H.-J., Bednar, F., Allen, B. L., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.05.004 · Cited by 110
Self-citationEpithelial and stromal co-evolution and complicity in pancreatic cancer
Hingorani, S. R. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00530-w · Cited by 108
Ruze, R., Song, J., Yin, X., Chen, Y., Xu, R., Wang, C., & Zhao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01376-w · Cited by 111
Diana, A., Wang, L. M., D’Costa, Z., Allen, P., Azad, A., Silva, M. A., Soonawalla, Z. F., Liu, S. K., McKenna, W. G., Muschel, R. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10038 · Cited by 89
Das, S., & Bar‐Sagi, D. (2019) · Oncogene · doi:10.1038/s41388-018-0668-3 · Cited by 87
Kras and tumor immunity: friend or foe?
Cullis, J., Das, S., & Bar-Sagi, D. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031849 · Cited by 85
Cellular determinants and therapeutic implications of inflammation in pancreatic cancer
Stone, M. L., & Beatty, G. L. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.012 · Cited by 87
Barilla, R., Diskin, B. E., Caso, R. C., Lee, K. B., Mohan, N., Buttar, C., Adam, S., Sekendiz, Z., Wang, J., Salas, R. D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09416-2 · Cited by 81
Mahadevan, K. K., LeBleu, V. S., Ramirez, E. V., Chen, Y., Li, B., Sockwell, A. M., Gagea, M., Sugimoto, H., Sthanam, L. K., Tampe, D., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.07.025 · Cited by 76
Alam, M. S., Gaida, M. M., Bergmann, F., Lasitschka, F., Giese, T., Giese, N. A., Hackert, T., Hinz, U., Hussain, S. P., Козлов, С. В., et al. (2015) · Nature Medicine · doi:10.1038/nm.3957 · Cited by 67
Goebel, L., Grage‐Griebenow, E., Gorys, A., Helm, O., Genrich, G., Lenk, L., Wesch, D., Ungefroren, H., Freitag‐Wolf, S., Sipos, B., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2014.1000083 · Cited by 65
WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer
Du, W., Menjivar, R. E., Donahue, K. L., Kadiyala, P., Velez-Delgado, A., Brown, K. L., Watkoske, H. R., He, X., Carpenter, E. S., Angeles, C. V., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220503 · Cited by 64
Self-citationType I conventional dendritic cells facilitate immunotherapy in pancreatic cancer
Mahadevan, K. K., Dyevoich, A. M., Chen, Y., Li, B., Sugimoto, H., Sockwell, A. M., McAndrews, K. M., Sthanam, L. K., Wang, H., Shalapour, S., et al. (2024) · Science · doi:10.1126/science.adh4567 · Cited by 71
Herting, C. J., Karpovsky, I., & Lesinski, G. B. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09988-w · Cited by 60
Pancreatic cancer microenvironment, to target or not to target?
Carr, R. M., & Fernández-Zapico, M. E. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505948 · Cited by 55
Epithelial-Stromal Interactions in Pancreatic Cancer
Zhang, Y., Crawford, H. C., & di Magliano, M. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114515 · Cited by 52
Self-citationPancreatic cancer: Update on immunotherapies and algenpantucel-L
McCormick, K. A., Coveler, A. L., Rossi, G. R., Vahanian, N. N., Link, C., & Chiorean, E. G. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1093264 · Cited by 42
Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer
Scales, M. K., Velez-Delgado, A., Steele, N. G., Schrader, H. E., Stabnick, A. M., Yan, W., Mercado-Soto, N. M., Nwosu, Z., Johnson, C. N., Zhang, Y.-Q., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010315 · Cited by 28
Self-citationZhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Cancer & Metabolism · doi:10.1186/s40170-022-00282-z · Cited by 32
Immune vulnerabilities of mutant KRAS in pancreatic cancer
Cheng, N. C., & Vonderheide, R. H. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.07.004 · Cited by 32
Self-citationBrouwer, T. P., Vries, N. L. D., Abdelaal, T., Krog, R. T., Li, Z., Ruano, D., Sarasqueta, A. F., Lelieveldt, B. P. F., Morreau, H., Bonsing, B. A., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004638 · Cited by 29
Eisenberg, V., Shamalov, K., Meir, S., Hoogi, S., Sarkar, R., Pinker, S., Markel, G., Porgador, A., & Cohen, C. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01212 · Cited by 26
Cancer Manipulation of Host Physiology: Lessons from Pancreatic Cancer
Zambirinis, C. P., & Miller, G. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.003 · Cited by 26
B-Lymphocytes in the Pathophysiology of Pancreatic Adenocarcinoma
Minici, C., Testoni, S. G. G., & Della‐Torre, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.867902 · Cited by 24
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesisPreprint
Wang, L., Yang, H., Zamperone, A., Diolaiti, D., Palmbos, P. L., Abel, E. V., Purohit, V., Dolgalev, I., Rhim, A. D., Ljungman, M. E., et al. (2019) · Genes & Development · doi:10.1101/gad.323303.118 · Cited by 24
Wang, X., Chen, H., Jiang, R., Hong, X., Peng, J., Chen, W., Jiang, J., Li, J., Huang, D., Dai, H., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.03.003 · Cited by 23
Du, W., di Magliano, M. P., & Zhang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.682217 · Cited by 22
Self-citationThe Role of Chemokines in Orchestrating the Immune Response to Pancreatic Ductal Adenocarcinoma
Lekan, A. A., & Weiner, L. M. (2024) · Cancers · doi:10.3390/cancers16030559 · Cited by 24
Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer
Halbrook, C. J., di Magliano, M. P., & Lyssiotis, C. A. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00416.2017 · Cited by 22
KRAS-Driven Tumorigenesis and KRAS-Driven Therapy in Pancreatic Adenocarcinoma
Than, M. T., O’Hara, M. H., Stanger, B. Z., & Reiss, K. A. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0519 · Cited by 22
Liu, Y., Feng, M., Chen, H., Yang, G., Qiu, J., Zhao, F., Cao, Z., Luo, W., Xiao, J., You, L., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.05.003 · Cited by 18
Context-Dependent Immune Responses Explain Pancreatic Cancer Immunoresistance
Bednar, F., & di Magliano, M. P. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.02.010 · Cited by 15
Self-citationTumor-Promoting Inflammatory Networks in Pancreatic Neoplasia: Another Reason to Loathe Kras
Vonderheide, R. H. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.020 · Cited by 15
Self-citationMarcucci, F., & Rumio, C. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03606-8 · Cited by 14
Bushnell, G. G., Orbach, S. M., Ma, J. A., Crawford, H. C., Wicha, M. S., Jeruss, J. S., & Shea, L. D. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120632 · Cited by 12
Wang, W., He, Y., Yao, L., Yuan, Y., Lu, C., Xiong, L., Ma, P., Zhang, Y., Yu, K., & Tang, Z. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167304 · Cited by 11
Self-citationThe role of stromal cells in epithelial–mesenchymal plasticity and its therapeutic potential
Wang, J., Peng, J., Chen, Y., Nasser, M. I., & Qin, H. (2024) · Discover Oncology · doi:10.1007/s12672-024-00867-8 · Cited by 13
Inflammation-Related Pancreatic Carcinogenesis
Dai, J., Jiang, M., Wang, X., & Tian, L. (2017) · Pancreas · doi:10.1097/mpa.0000000000000886 · Cited by 11
Murine Models of Pancreatitis Leading to the Development of Pancreatic Cancer
Leal, A. S., & Liby, K. T. (2018) · Current Protocols in Pharmacology · doi:10.1002/cpph.48 · Cited by 11
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Li, X., Hou, W., Xiao, C., Yang, H., Zhao, C., & Cao, D. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00970-6 · Cited by 10
Precision immune regulation in KRAS-mutated cancers: the final piece of the puzzle?
Fu, S., Ma, J., Cai, C., Tan, J., Deng, X., Shen, H., Zeng, S., Chen, Y., & Han, Y. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03444-1 · Cited by 11
Pancreatic Cancer Fostered Immunosuppression Privileges Tumor Growth and Progression
Basso, D. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000278 · Cited by 7
Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC
Musiu, C., Lupo, F., Agostini, A., Lionetto, G., Bevere, M., Paiella, S., Carbone, C., Corbo, V., Ugel, S., & Sanctis, F. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1341079 · Cited by 9
Lawal, B., Lo, W., Mokgautsi, N., Sumitra, M. R., Khedkar, H., Wu, A. T. H., & Huang, H. (2021) · PubMed Central · Cited by 9
Zhou, Q., Chen, D., Zhang, J., Xiang, J.-F., Zhang, T., Wang, H., & Zhang, Y. (2022) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000109 · Cited by 9
Self-citationZi, R., Shen, K., Zheng, P., Su, X., Yang, Y., Chen, Y., Dai, H., Mao, C., Lu, Y., Wang, L., et al. (2025) · The Innovation · doi:10.1016/j.xinn.2024.100783 · Cited by 8
Chen, Y., Wang, J., Guo, Q., Li, X., & Zou, X. (2022) · Cancers · doi:10.3390/cancers14215439 · Cited by 8
Mahadevan, K. K., Maldonado, A. S., Li, B., Bickert, A. A., Perdyan, A., Kumbhar, S. V., Piya, S., Sockwell, A. M., Morse, S. J., Arian, K. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.28.640711 · Cited by 7
Drug development and clinical trial design in pancreatico-biliary malignancies
Harrington, J., Carter, L., Basu, B., & Cook, N. (2018) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2018.01.003 · Cited by 6
Gao, Z., Zhang, Q., Zhang, X., & Song, Y. (2022) · European Journal of Inflammation · doi:10.1177/1721727x221092900 · Cited by 6
The science of tumor-infiltrating lymphocytes (TIL): perspectives from the SITC Surgery Committee
Coukos, G., Donia, M., Gastman, B., Goff, S. L., Gros, A., Harari, A., Hernandez, S., Ito, F., Maker, A. V., Mullinax, J. E., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-013420 · Cited by 7
Chang, J., Lo, Z. H. Y., Alenizi, S., & Kovačević, Ž. (2023) · Cancers · doi:10.3390/cancers15102779 · Cited by 5
Walcheck, M. T., Schwartz, P. B., Carrillo, N. D., Matkowskyj, K. A., Nukaya, M., Bradfield, C. A., & Ronnekleiv‐Kelly, S. M. (2024) · Pancreas · doi:10.1097/mpa.0000000000002357 · Cited by 5
Zhang, J., Jiang, S., Gu, D., Zhang, W., Shen, X., Qu, M., Yang, C., Wang, Y., & Gao, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1162653 · Cited by 5
Immune cells in pancreatic cancer
Zhang, Y., McAllister, F. M., & di Magliano, M. P. (2014) · OncoImmunology · doi:10.4161/onci.29125 · Cited by 5
Self-citationGriffith, B. D., Kadiyala, P., McGue, J. J., Sun, L., Kumar, A., Espinoza, C. E., Donahue, K. L., Iyer, M. K., Speyer, C. B., Nelson, S., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0377 · Cited by 5
Self-citationMahadevan, K. K., Maldonado, A. S., Li, B., Bickert, A. A., Perdyan, A., Kumbhar, S. V., Piya, S., Sockwell, A. M., Morse, S. J., Arian, K. A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75960-3 · Cited by 12
Mahadevan, K. K., Dyevoich, A. M., Chen, Y., Li, B., Sugimoto, H., Sockwell, A. M., McAndrews, K. M., Wang, H., Shalapour, S., Watowich, S. S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.05.531191 · Cited by 3
Sahu, P., Mitra, A., & Ganguly, A. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2024.01.005 · Cited by 2
Daniluk, U., Swidnicka-Siergiejko, A. K., Daniluk, J., Rusak, M., Dąbrowska, M., Guzińska-Ustymowicz, K., Pryczynicz, A., & Dâbrowski, A. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1603293 · Cited by 2
Therapeutic vaccines for pancreatic cancer
Tekkeşin, N., & Tetik, Ş. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-819457-7.00014-1 · Cited by 2
Sharma, N., Gupta, V. K., Garrido, V. T., Hadad, R., Durden, B. C., Kesh, K., Ferrantella, A. R., Giri, B., Dudeja, V., Banerjee, S., et al. (2019) · Pancreatology · doi:10.1016/j.pan.2019.05.430 · Cited by 2
Stromal Inflammation in Pancreatic Cancer: Mechanisms and Translational Applications
Boyle, K. A., James, M. A., Tsai, S., Evans, D. B., & Dwinell, M. B. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6631-8_55-1 · Cited by 1
Stromal Inflammation in Pancreatic Cancer: Mechanisms and Translational Applications
Boyle, K. A., James, M. A., Tsai, S., Evans, D. B., & Dwinell, M. B. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7193-0_55 · Cited by 1
Adhikary, P., Chakrabarti, J. L., Mallick, S., Sun, X., Ezuma-Igwe, U., Branch, A. G., Wang, J., Braissand, N., Corbett, M. P., Kim, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.22.655586 · Cited by 2
Winograd, R. (2015) · ScholarlyCommons (University of Pennsylvania)
Pancreatic Cancer Fostered Immunosuppression Privileges Tumor Growth and
Gnatta, E., Plebani, M., & Basso, D. (2014)
Loss of TIP30 Accelerates Pancreatic Cancer Progression and Metastasis
Williams, I., & Imade, E. (2019)
Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine
Hegde, S. (2020) · Indian Journal of Surgical Oncology · doi:10.1007/s13193-020-01192-6
The Prospects of Immunotherapy in Pancreatic Cancer
Ying, H., & Yao, W. (2022) · Springer eBooks · doi:10.1007/978-3-031-05724-3_22
Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211339
Liu, Y., Xu, F., Jiang, A., Ding, J., Li, C., & Quan, M. (2024) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000180
Qin, D., Huang, K., Yao, Z., Xi, P., Jiang, L., Wei, R., & Li, S. (2024) · Research Square · doi:10.21203/rs.3.rs-4829619/v1
Pankaj, A., Raabe, M. J., Zhang, M. L., Song, Y., Patel, B. K., Xu, K., Kocher, J. R., Lang, E., Richieri, P., Caldwell, N. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.14.632658
Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211348
Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211351
Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211336
Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211345
Metadata
- Authors
- Zhang, Y., Yan, W., Mathew, E., Bednar, F., Wan, S., Collins, M. A., Evans, R. A., Welling, T. H., Vonderheide, R. H., & di Magliano, M. P.
- Affiliations
- University of Michigan (US)
- Authors' Affiliations: Departments of 1Surgery, 2Pathology, and 3Cell and Developmental Biology, 4Michigan Center for Translational Pathology, 5Program in Cellular and Molecular Biology; 6Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan; 7Abramson Family Cancer Research Institute; and 8Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
- Venue
- Cancer Immunology Research
- Published
- 2014-05-01
- Volume
- 2
- Issue
- 5
- Pages
- 423-435
- ISSN
- 2326-6066 (ISSN-L)
- 2326-6074
- PMC
- PMC4160804
- OpenAlex
- W2139909490
- Cited by
- 102
- References
- 41
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 16 · 2021: 6 · 2020: 10 · 2019: 12 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 4
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Immunology Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Vanderbilt University
- National Cancer Institute (R01CA151588, K08CA151414, R01CA169123)
- National Institute of General Medical Sciences (T32GM007315)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933, T32DK094775)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5-T32-HD007515, T32HD007505)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- CD4+ T cells, pancreatic carcinogenesis, pancreatic intraepithelial neoplasia, oncogenic KRAS, CD8+ T cells, immunosuppressive tumor microenvironment, immune tolerance, pancreatitis, immunomodulatory therapy
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Disease Models, Animal, Lymphocyte Depletion, Pancreatic Neoplasms, Pancreatitis, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Proto-Oncogene Proteins p21(ras), Apoptosis, Mice, Knockout, Lymphocyte Count, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
