Electrolytes, water, RNA, total creatine and calculated resting membrane potential in muscle tissue from pregnant women
Abstract
BACKGROUND: The nutritional situation of the fetus and pregnant woman is important for human health, but knowledge of how nutrition affects maternal metabolism and physiology during pregnancy is limited. Such knowledge is important, for example in body composition studies, when information about lean tissue composition is needed. Muscle, a main part of lean tissue, changes its composition in response to age and sex, but the effect of pregnancy on this composition is unknown. METHODS: Muscle samples from 11 pregnant and 16 nonpregnant women were analyzed for water, electrolytes, total creatine, alkali-soluble protein (ASP), DNA and RNA. Plasma was analyzed for electrolytes. The amount of extracellular and intracellular water as well as the resting membrane potential (RMP) in muscle were calculated. RESULTS: Pregnant women had lower plasma concentrations of potassium and sodium but higher muscle concentrations of sodium and water (total and extracellular) than nonpregnant women. RMP was more negative in pregnant than in nonpregnant women. Total creatine in muscle (per kilogram ASP) was increased during pregnancy. The muscle content of RNA (per kilogram DNA) was lower in gestational week 18 than in nonpregnant controls. CONCLUSION: Pregnancy influences muscle composition in several ways that are relevant for an increased understanding of interactions between nutrition and reproduction.
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Inflammation in pregnancy is associated with modest hypoalbuminemia, progressing from the first to the third trimester and paralleled by increased water content of the maternal interstitium.
“The inflammation present in pregnancy is associated with modest hypoalbuminemia, which progresses from the first to the third trimester and is paralleled by increased water content of the maternal interstitium.30, 110, 111”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [111]
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- Authors
- Forsum, E., Forsberg, A. M., Nilsson, E., Bergström, J., & Hultman, E.
- Affiliations
- Linköping University (SE)
- Karolinska Institutet (SE)
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 44
- Issue
- 4
- Pages
- 144-149
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2068689032
- Semantic Scholar
- c629222562e554c59f4d38b7844ce2c7d06667d1
- Cited by
- 9
- References
- 22
- Citations by year
- 2022: 2 · 2021: 1 · 2018: 1 · 2015: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- pregnancy, muscle composition, resting membrane potential, extracellular water, intracellular water, muscle electrolytes, sodium, potassium, creatine, RNA, DNA, lean tissue, maternal metabolism, nutrition and reproduction
- MeSH terms
- Adult, Body Composition, Body Water, Creatine, Electrolytes, Female, Humans, Membrane Potentials, Nutritional Status, Potassium, Pregnancy, RNA, Sodium, Muscle, Skeletal
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