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Cited by 282Nutrition and Health in AgingMuscle metabolism and nutritionMuscle Physiology and Disorders

Muscle composition in relation to age and sex

Forsberg, A. M., Nilsson, E., Werneman, J., Bergström, J., Hultman, E.·1991·Clinical Science
DOI 10.1042/cs0810249
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Abstract

1. A method is described enabling the determination of fat, water, electrolytes, protein, DNA, RNA and total creatine in a single sample of human muscle obtained by the percutaneous needle-biopsy technique. The amino acid content can also be analysed in the same muscle sample. 2. Fifty healthy subjects were studied: 29 between 19 and 40 years of age, 11 between 41 and 60 years of age, and 10 between 61 and 85 years of age. The two groups aged less than 60 years showed only marginal differences in muscle composition, whereas the highest age group showed increases in muscle fat content in relation to tissue weight and decreases in alkali-soluble protein content in relation to both tissue weight and tissue DNA content. Also, potassium, magnesium, total creatine and RNA contents were decreased in this age group when related to tissue DNA content. When alkali-soluble protein was used as a reference base, only magnesium content was decreased. 3. A comparison was also made between female (n = 23) and male (n = 18) subjects in the age groups below 60 years. Differences observed included a higher fat content in female muscle, and an increase in total creatine content in relation to tissue weight. The alkali-soluble protein content was lower per muscle cell in the females when calculated on the basis of DNA content. 4. The results show that in the assessment of muscle constituents, age and sex must be taken into account.

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Crossref · 10.1042/cs0810249

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  • Compared to men, females exhibit 70-80% lower endogenous intramuscular phosphocreatine stores and consume considerably lower amounts of dietary creatine.

    “Compared to men, females exhibit 70–80% lower endogenous intramuscular phosphocreatine stores and consume considerably lower amounts of dietary creatine [307]”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [307]

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Authors
Forsberg, A. M., Nilsson, E., Werneman, J., Bergström, J., & Hultman, E.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Werneman, J.
ORCID
Venue
Clinical Science
Publisher
Portland Press Ltd.
Published
1991-08-01
Volume
81
Issue
2
Pages
249-256
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
DOI
10.1042/cs0810249
OpenAlex
W133295433
Cited by
282
References
20
Citations by year
2026: 7 · 2025: 12 · 2024: 10 · 2023: 11 · 2022: 11 · 2021: 14 · 2020: 15 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 3 · 2013: 3 · 2012: 9
FWCI
2.98
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
muscle composition, aging, sex differences, human skeletal muscle, muscle fat content, alkali-soluble proteins, creatine, RNA content, DNA content, electrolytes, potassium, magnesium, amino acids, percutaneous needle biopsy
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Amino Acids, Creatine, DNA, Electrolytes, Female, Humans, Lipids, Male, Middle Aged, Muscle Proteins, Muscles, RNA, Sex Factors, Water

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