A Review of Infantile and PediatricAcne
Abstract
Acne occurs primarily in the first year of life and at puberty. Neonatal and infantile acne may reflect the relatively high androgens from the adrenal in girls and the adrenal and testes in boys characteristic of this age. Early in puberty, acne in boys and girls is primarily comedonal and midfacial. The best predictors of severe acne are early onset of comedones and serum levels of dehydroepiandrosterone sulfate. Early recognition and therapy of acne may prevent scarring and psychological stress.
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Androgens have a central role in acne.
“Androgens have a central role in acne, since acne onset is correlated with adrenarchal rise of blood DHEA-S levels [194], it manifests in congenital adrenal hyperplasia [195], is seen during hyperadrogenism in women [196], and it develops during anabolic steroid administration [197].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [194]
Cites
Acne Vulgaris in Premenarchal Girls
Lucky, A. W. (1994) · Archives of Dermatology · doi:10.1001/archderm.130.3.308 · Cited by 211 · see citing works
Lucky, A. W., Biro, F. M., Simbartl, L. A., Morrison, J. A., & Sorg, N. W. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70307-x · Cited by 184 · see citing works
Acne Vulgaris in Early Adolescent Boys
Lucky, A. W. (1991) · Archives of Dermatology · doi:10.1001/archderm.127.2.210 · Cited by 129 · see citing works
Sebaceous Gland Activity and Serum Dehydroepiandrosterone Sulfate Levels in Boys and Girls
Stewart, M. E. (1992) · Archives of Dermatology · doi:10.1001/archderm.1992.01680200055006 · Cited by 110 · see citing works
Pathogenesis and Treatment of Acne in Childhood
Jansen, T., Burgdorf, W. H. C., & Plewig, G. (1997) · Pediatric Dermatology · doi:10.1111/j.1525-1470.1997.tb00420.x · Cited by 95 · see citing works
Acne, Hirsutism, and Alopecia in Adolescent Girls: Clinical Expressions of Androgen Excess
Rosenfield, R. L., & Lucky, A. W. (1993) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30148-8 · Cited by 82 · see citing works
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Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Zouboulis, C., Chen, W.-C., Thornton, M., Qin, K., & Rosenfield, R. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-961807 · Cited by 379 · see citing works
Skin steroidogenesis in health and disease
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76 · see citing works
- Authors
- W. Lucky, A.
- Venue
- Dermatology
- Publisher
- S. Karger AG
- Published
- 1998
- Volume
- 196
- Issue
- 1
- Pages
- 95-97
- ISSN
- 1018-8665 (ISSN-L)
- 1421-9832
- OpenAlex
- W2015894408
- Cited by
- 98
- References
- 6
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 3
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- infantile acne, neonatal acne, pediatric acne, androgens, adrenal androgens, dehydroepiandrosterone sulfate, comedones, acne scars, acne treatment
- MeSH terms
- Acne Vulgaris, Child, Humans, Infant, Newborn
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