The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions
Abstract
The insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and IGFBP proteases regulate somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogens whose actions are determined by the availability of free IGFs to interact with IGF receptors. IGFBPs comprise a family of six proteins that bind IGFs with high affinity and specificity and thereby regulate IGF-dependent actions. IGFBPs have recently emerged as IGF-independent regulators of cell growth. Cleavage of IGFBPs by specific proteases modulate levels of free IGFs and IGFBPs and thereby their actions. IGFBP-related proteins (IGFBP-rPs) bind IGFs with low affinity and also play important roles in cell growth and differentiation. The GH-IGF-IGFBP axis is complex and powerful. Future research on its physiology promises exciting insights into cell biology as well as therapies for diseases such as cancer and diabetes mellitus.
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Cites
The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p
Jay, P., Bergé-Lefranc, J. L., Marsollier, C., Méjean, C., Taviaux, S., & Berta, P. (1997) · Oncogene · doi:10.1038/sj.onc.1200986 · Cited by 67
Cited by
Acne vulgaris: a disease of Western civilization
Cordain, L., Lindeberg, S., Hurtado, M., Hill, K., Eaton, S. B., & Brand-Miller, J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.12.1584 · Cited by 500
Sandhu, M. S., Heald, A. H., Gibson, J. M., Cruickshank, J. K., Dunger, D. B., & Wareham, N. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08655-5 · Cited by 470
IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
Mohan, S., & Baylink, D. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750019 · Cited by 444
Liu, J., Jin, X., Liu, K. J., & Liu, W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6409-11.2012 · Cited by 434
Liu, B., Lee, H.-Y., Weinzimer, S. A., Powell, D. R., Clifford, J. L., Kurie, J. M., & Cohen, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002547200 · Cited by 326
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Metadata
- Authors
- Ferry Jr., R. J., Cerri, R. W., & Cohen, P.
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 1999
- Volume
- 51
- Issue
- 2
- Pages
- 53-67
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W2053401836
- Cited by
- 205
- References
- 1
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ferry Jr., R. J., Cerri, R. W., & Cohen, P. (1999). Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions. Hormone Research in Paediatrics. https://doi.org/10.1159/000023315
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
