The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p
Abstract
Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.
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The human CCN1 gene and AVSD1 both map within the same chromosomal location at 1p21-31, suggesting that CCN1 may be a candidate gene for human AVSD.
“The human CCN1 gene and AVSD1 both map within the same chromosomal location at 1p21–31 [97,98], suggesting that CCN1 may be a candidate gene for human AVSD.”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [98]
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- Authors
- Jay, P., Bergé-Lefranc, J. L., Marsollier, C., Méjean, C., Taviaux, S., & Berta, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- ORCID
- Jay, P
- Venue
- Oncogene
- Published
- 1997-04-10
- Volume
- 14
- Issue
- 14
- Pages
- 1753-1757
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2321720716
- Cited by
- 67
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- CYR61, chromosome 1p, immediate early genes, cysteine-rich proteins, protein domain structure, mouse homolog, proto-oncogenes, cell proliferation, lineage commitment, embryonic development, gene mapping
- MeSH terms
- Proto-Oncogene Mas, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 1, Cloning, Molecular, Growth Substances, Humans, Molecular Sequence Data, RNA, Messenger, Gene Expression, Sequence Alignment, Sequence Homology, Amino Acid, In Situ Hybridization, Fluorescence, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Cysteine-Rich Protein 61
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