The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Alternative versus Classical Activation of Macrophages
Abstract
In parallel to the Th1/Th2 paradigm, antigen-presenting cells (APC) are divided into classically activated APC (dendritic cells/effector macrophages) and alternatively activated APC (IL-4-induced, alternatively activated macrophages/IL-10-induced, immature dendritic cells). Alternatively activated APC share a special molecular repertoire including receptors of innate immunity with broad specificity for foreign antigen and anti-inflammatory cytokines such as IL-1Ra and alternative macrophage activation-associated CC-chemokine-1. Alternatively activated APC mediated tolerance and downregulated inflammation. Abuse of alternatively activated APC in support of infectious susceptibility or tumor immune escape is counteracted by the classical pathway. Thus, classically and alternatively activated APC secure the balance between proinflammatory and anti-inflammatory immune reactions.
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Cites
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Induction of tolerance by IL-10-treated dendritic cells
Steinbrink, K., Wölfl, M., Jonuleit, H., Knop, J., & Enk, A. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.10.4772 · Cited by 1,246
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Tumor-induced immune dysfunction: the macrophage connection
Elgert, K. D., Alleva, D. G., & Mullins, D. W. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.64.3.275 · Cited by 426
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Self-citationDifferences in angiogenic potential of classically vs alternatively activated macrophages
Kodelja, V., Müller, C., Tenorio, S., Schebesch, C., Orfanos, C. E., & Goerdt, S. (1997) · Immunobiology · doi:10.1016/s0171-2985(97)80080-0 · Cited by 186
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Cited by
Martinez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,125
The many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902
Hu, X., Li, P., Guo, Y., Wang, H., Leak, R. K., Chen, S., Gao, Y., & Chen, J. (2012) · Stroke · doi:10.1161/strokeaha.112.659656 · Cited by 1,535
Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816
Metadata
- Authors
- Goerdt, S., Politz, O., Schledzewski, K., Birk, R., Gratchev, A., Guillot, P., Hakiy, N., Klemke, C.-D., Dippel, E., Kodelja, V., & Orfanos, C. E.
- Venue
- Pathobiology
- Publisher
- S. Karger AG
- Published
- 1999
- Volume
- 67
- Issue
- 5-6
- Pages
- 222-226
- ISSN
- 1015-2008 (ISSN-L)
- 1423-0291
- OpenAlex
- W2045833339
- Cited by
- 324
- References
- 16
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Alternative versus Classical Activation of Macrophages. https://app.cochat.ai/papers/10.1159/000028096
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- Goerdt, S., Politz, O., Schledzewski, K., Birk, R., Gratchev, A., Guillot, P., Hakiy, N., Klemke, C.-D., Dippel, E., Kodelja, V., & Orfanos, C. E. (1999). Alternative versus Classical Activation of Macrophages. Pathobiology. https://doi.org/10.1159/000028096
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
