11-Deoxycorticosterone-producing adrenocortical carcinoma
Abstract
A woman presented with a history of weight loss and muscle weakness. A laboratory test revealed hypokalemia and elevation of plasma 11-deoxycorticosterone (DOC). CT showed a left adrenal mass. A left adrenalectomy was performed. The histological and immunohistochemical diagnosis showed a DOC-producing adrenocortical carcinoma. This cancer is very rare; only 10 cases including the present case have appeared in the literature.
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More commonly, mineralocorticoid effects are mediated by high cortisol levels or possibly steroid precursors with mineralocorticoid activity, such as 11-deoxycorticosterone.
“More commonly, mineralocorticoid effects are mediated by high cortisol levels or possibly steroid precursors with mineralocorticoid activity, such as 11-deoxycorticosterone (87, 88).”
From Adrenocortical carcinoma (2014) · cites this paper as [87]
Cites
SOME STUDIES ON THE BIOSYNTHESIS OF ALDOSTERONE AND OTHER ADRENAL STEROIDS
Ayres, P. J., Eichhorn, J. H., Hechter, O., et al. (1960) · European Journal of Endocrinology · doi:10.1530/acta.0.xxxiii0027 · Cited by 61 · see citing works
Pathophysiology of Deoxycorticosterone-Secreting Adrenal Tumors*
Irony, I., Biglieri, E. G., Perloff, D. L., & Rubinoff, H. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-5-836 · Cited by 44 · see citing works
Excess deoxycorticosterone secretion from adrenocortical carcinoma.
Powell-Jackson, J. D., Călin, A., Fraser, R., Grahame, R., Mason, P. A., Missen, G. A. K., Powell-Jackson, P. R., & Wilson, A. (1974) · BMJ · doi:10.1136/bmj.2.5909.32 · Cited by 37 · see citing works
Kelly, W. F., O’Hare, M. J., Loizou, S., DAVIES, D., & Laing, I. (1982) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1982.tb01600.x · Cited by 24 · see citing works
Benign desoxycorticosterone-producing adrenal tumor
Kondo, K. (1976) · JAMA · doi:10.1001/jama.236.9.1042 · Cited by 7 · see citing works
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Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
Müssig, K., Wehrmann, M., Horger, M., Maser-Gluth, C., Häring, H.-U., & Overkamp, D. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345531 · Cited by 43 · see citing works
- Authors
- Egoshi, K.-I., Masai, M., Nagao, K., & Ito, H.
- Affiliations
- Teikyo University (JP)
- ORCID
- Masai, Motoyuki
- Venue
- Urologia Internationalis
- Publisher
- S. Karger AG
- Published
- 1998
- Volume
- 61
- Issue
- 4
- Pages
- 251-253
- ISSN
- 0042-1138 (ISSN-L)
- 1423-0399
- OpenAlex
- W2004651907
- Cited by
- 5
- References
- 5
- Citations by year
- 2022: 1 · 2013: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Urologia Internationalis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- adrenocortical carcinoma, deoxycorticosterone, hyperaldosteronism, hypokalemia, adrenal mass, adrenalectomy, rare adrenal tumor, weight loss, muscle weakness
- MeSH terms
- Adrenal Cortex Neoplasms, Adrenalectomy, Desoxycorticosterone, Female, Follow-Up Studies, Humans, Immunohistochemistry, Middle Aged, Treatment Outcome, Adrenocortical Carcinoma
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