Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension
Abstract
A 37-yr-old man presented with the classic signs of mineralocorticoid excess hypertension and hypokalemia. The cause was not aldosterone excess, but elevation of plasma 11-deoxycorticosterone (DOC). Computed tomography (CT) scans showed a large right adrenal mass without signs of metastatic disease. The tumor was removed by open laparotomy, and histology revealed an adrenocortical carcinoma. Two yr after diagnosis, the patient is in good general condition and there is no sign of recurrence or metastatic disease, despite the large tumor size. DOC producing adrenocortical carcinomas causing mineralocorticoid hypertension are very rare, so far only 10 cases have been described in the literature.
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More commonly, mineralocorticoid effects are mediated by high cortisol levels or possibly steroid precursors with mineralocorticoid activity, such as 11-deoxycorticosterone.
“More commonly, mineralocorticoid effects are mediated by high cortisol levels or possibly steroid precursors with mineralocorticoid activity, such as 11-deoxycorticosterone (87, 88).”
From Adrenocortical carcinoma (2014) · cites this paper as [88]
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- Authors
- Müssig, K., Wehrmann, M., Horger, M., Maser-Gluth, C., Häring, H.-U., & Overkamp, D.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Overkamp, D.
- ORCID
- Venue
- Journal of Endocrinological Investigation
- Published
- 2005-03
- Volume
- 28
- Issue
- 3
- Pages
- 61-65
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W1991675930
- Cited by
- 43
- References
- 18
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 7
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenocortical carcinoma, deoxycorticosterone, hypokalemia, adrenal mass, surgical resection
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Cortex Neoplasms, Adrenalectomy, Adult, Aldosterone, Catecholamines, Desoxycorticosterone, Humans, Hypertension, Hypokalemia, Male, Mineralocorticoids, Pheochromocytoma, Renin, Tomography, X-Ray Computed
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