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Consequences of Total and Subtotal Myeloperoxidase Deficiency: Risk or Benefit ?
Abstract
A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated.
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Citations
Cited by
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Myeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282
Reactive oxygen species in cardiovascular disease
Sugamura, K., & Keaney (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.004 · Cited by 769
Regulation of Reactive Oxygen Species Generation in Cell Signaling
Bae, Y. S., Oh, H., Rhee, S. G., & Yoo, Y. D. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0276-3 · Cited by 658
ROS production in phagocytes: Why, when, and where?
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Metadata
- Authors
- Kutter, D., Devaquet, P., Vanderstocken, G., Paulus, J. M., Marchal, V., & Gothot, A.
- Venue
- Acta Haematologica
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 104
- Issue
- 1
- Pages
- 10-15
- ISSN
- 0001-5792 (ISSN-L)
- 1421-9662
- OpenAlex
- W2073913945
- Cited by
- 250
- References
- 0
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kutter, D., Devaquet, P., Vanderstocken, G., Paulus, J. M., Marchal, V., & Gothot, A. (2000). Consequences of Total and Subtotal Myeloperoxidase Deficiency: Risk or Benefit ? Acta Haematologica. https://doi.org/10.1159/000041062
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.