ROS production in phagocytes: Why, when, and where?

Dupré-Crochet, Sophie; Erard, Marie; Nüβe, Oliver

doi:10.1189/jlb.1012544

Cited by 467Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

ROS production in phagocytes: Why, when, and where?

Dupré-Crochet, Sophie, Erard, Marie, Nüβe, Oliver·2013·Journal of Leukocyte Biology

DOI 10.1189/jlb.1012544

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Abstract

In the phagocytosis field, ROS production by the phagocyte NOX has been associated with pathogen killing for the last 50 years. Since the discovery of nonphagocyte NOX, numerous other roles for ROS production have been identified. Oxidative stress and ROS-mediated signaling have received much attention in recent years. Much lower concentrations of ROS may be required for signaling compared with microbial killing. Based on the discoveries in nonphagocytic cells, it became logical to look for ROS functions distinct from pathogen killing, even in phagocytes. ROS are now linked to various forms of cell death, to chemotaxis, and to numerous modifications of cellular processes, including the NOX itself. ROS functions are clearly concentration-dependent over a wide range of concentrations. How much is required for which function? Which species are required for how much time? Is ROS signaling only a side effect of bactericidal ROS production? One major obstacle to answer these questions is the difficulty of reliable quantitative ROS detection. Signal transduction often takes place on a subcellular scale over periods of seconds or minutes, so the detection methods need to provide appropriate time and space resolution. We present examples of local ROS production, decreased degradation, signaling events, and potentially ROS-sensitive functions. We attempt to illustrate the current limitations for quantitative spatiotemporal ROS detection and point out directions for ongoing development. Probes for localized ROS detection and for combined detection of ROS, together with protein localization or other cellular parameters, are constantly improved.

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Alongside O2•−-induced lysis of bacteria in the phagosome through oxidative damage, defence against pathogens is also triggered by non-oxidative means such as autophagy, receptor signalling, extracellular trap formation and instruction of lymphocyte responses.
“Alongside the ability of O2•− to induce lysis of bacteria in the phagosome through oxidative damage to bacterial biomolecules, defence against pathogens is also triggered by various non-oxidative means, such as autophagy, receptor signalling, extracellular trap formation and instruction of lymphocyte responses [171].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [171]

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King-Smith (1997) · doi:10.1002/(sici)1097-0169(1997)38:3

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Authors: Dupré-Crochet, S., Erard, M., & Nüβe, O.
Affiliations: University Paris-Sud , Orsay, France
Université Paris-Sud (FR)
Corresponding author: Nüβe, Oliver
ORCID: Erard, Marie
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2013-10-01
Volume: 94
Issue: 4
Pages: 657-670
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.1012544
OpenAlex: W2131917465
Cited by: 467
References: 166
Citations by year: 2026: 26 · 2025: 35 · 2024: 34 · 2023: 35 · 2022: 54 · 2021: 58 · 2020: 47 · 2019: 40 · 2018: 37 · 2017: 32 · 2016: 35 · 2015: 17 · 2014: 16 · 2013: 1
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Centre National de la Recherche Scientifique
University Paris-Sud (GDR2588)
French Ministry of Research
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: reactive oxygen species, phagocytes, NADPH oxidase, phagocytosis, oxidative stress, ROS signaling, cell death, chemotaxis, pathogen killing
MeSH terms: Animals, Humans, Phagocytes, Phagocytosis, Signal Transduction, Cell Death, Reactive Oxygen Species, Models, Immunological

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