Cited by 223Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

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Clinical Subtypes of Alzheimer’s Disease

Petersen, R.C.·1998·Dementia and Geriatric Cognitive Disorders

DOI 10.1159/000051199

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Abstract

Alzheimer's disease (AD) can present as a variety of clinical profiles. Although the most common presentation is that of a progressive amnestic disorder with subsequent involvement of other cognitive functions and personality alterations, there are numerous other clinical profiles. AD can present as a focal cortical degenerative syndrome with the clinical features dependent on the regions of the brain involved. Some of these syndromes include disturbances of language, visuospatial skills, attentional functions, executive processes and praxis. The neuropathological substrate of these disorders is variable and can include AD. Recently, the Lewy body variant of AD has been described. Finally, other modifying features that affect the progression of AD, such as extrapyramidal symptoms and myoclonus, are also discussed. Although the progressive amnestic form of AD is the most common presentation, other variations on the clinical syndrome can be important to identify because they may have implications for prognosis and treatment.

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Authors: Petersen, R. C.
Affiliations: Mayo Clinic (US)
Corresponding author: Petersen, R.C.
ORCID: Petersen, R.C.
Venue: Dementia and Geriatric Cognitive Disorders
Publisher: S. Karger AG
Published: 1998
Volume: 9
Issue: Suppl. 3
Pages: 16-24
ISSN: 1420-8008 (ISSN-L)
1421-9824
DOI: 10.1159/000051199
OpenAlex: W1982494036
Cited by: 223
References: 57
Citations by year: 2024: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 13 · 2012: 9
FWCI: 1.75
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Dementia and Geriatric Cognitive Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns029059-03)
National Institute on Aging (AG-08031, P30AG008031, AG-06786, U01AG006786)
National Institute of Neurological Disorders and Stroke (NS 29059)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: Alzheimer's disease, clinical subtypes, language disorders, visuospatial impairment, attentional dysfunction, executive dysfunction, praxis, extrapyramidal symptoms, myoclonus, neuropathology, prognosis
MeSH terms: Aged, Alzheimer Disease, Basal Ganglia Diseases, Humans, Middle Aged, Parkinson Disease, Syndrome

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