The SAHA Syndrome
Abstract
The presence of seborrhoea, acne, hirsutism and alopecia in women has first been summarized as SAHA syndrome in 1982 and can be associated with polycystic ovary syndrome, cystic mastitis, obesity and infertility. In 1994, the association of these androgen-dependent cutaneous signs, was classified according to their etiology into four types: (1) idiopathic, (2) ovarian, (3) adrenal, and (4) hyperprolactinemic SAHA. The HAIRAN syndrome has been currently described as a fifth variant with polyendocrinopathy. The SAHA syndrome generally occurs in young to middle-aged women and involves either the presence of elevated blood levels of androgens or increased androgen-driven peripheral response with normal circulating androgen levels. Peripheral metabolism of androgens takes place in various areas within the pilosebaceous unit, as indicated by local differences in the activities of aromatase, 5α-reductase as well as of the presence of the androgen receptors. In cases of SAHA syndrome, careful diagnostic and clinical evaluation has to be performed in order to identify the cause for peripheral hyperandrogenism and to exclude androgen-producing tumors. Treatment will target the etiology, whereas the management in idiopathic cases will aim to improve the clinical features of SAHA.
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Cutaneous manifestations of SAHA syndrome are common in androgen excess.
“Cutaneous manifestations (SAHA syndrome [198] – seborrhea, acne, hirsutism, male-pattern alopecia) are common in cases of androgen excess.”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [198]
Up to half of total circulating testosterone is produced from skin and other peripheral organs.
“Up to half of the total circulating T is produced from skin and other peripheral organs [198].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [198]
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Cites
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Acne and sebaceous gland function
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Self-citationSteroidogenesis in the skin: Implications for local immune functions
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- Authors
- Orfanos, C. E., Adler, Y. D., & Zouboulis, C. C.
- Affiliations
- Freie Universität Berlin (DE)
- National and Kapodistrian University of Athens (GR)
- Städtisches Klinikum Dessau (DE)
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 54
- Issue
- 5-6
- Pages
- 251-258
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W2001491518
- Cited by
- 92
- References
- 4
- Citations by year
- 2025: 2 · 2024: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research in Paediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Keywords
- seborrhea, acne, hirsutism, hair loss, polycystic ovary syndrome, androgen metabolism, aromatase, 5α-reductase, androgen receptor, hyperprolactinemia, ovarian androgen production, adrenal androgen production, androgen-producing tumors, infertility, obesity, polyendocrinopathy, women
- MeSH terms
- Acne Vulgaris, Alopecia, Hirsutism, Humans, Dermatitis, Seborrheic, Syndrome
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