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Cited by 397Vitamin K Research StudiesAntioxidant Activity and Oxidative StressNutritional Studies and Diet

The DOI matches its Crossref record, with a small difference in title or year; 32 of the 33 references it cites were found in a registry or an index.

Determination of Phylloquinone and Menaquinones in Food

Schurgers, Leon J., Vermeer, Cees·2000·Pathophysiology of Haemostasis and Thrombosis
DOI 10.1159/000054147
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Abstract

Fluctuations in international normalized ratio values are often ascribed to dietary changes in vitamin K intake. Here we present a database with vitamin K(1) and K(2) contents of a wide variety of food items. K(1) was mainly present in green vegetables and plant margarins, K(2) in meat, liver, butter, egg yolk, natto, cheese and curd cheese. To investigate the effect of the food matrix on vitamin K bioavailability, 6 healthy male volunteers consumed either a detergent-solubilized K(1) (3.5 micromol) or a meal consisting 400 g of spinach (3.5 micromol K(1)) and 200 g of natto (3.1 micromol K(2)). The absorption of pure K(1) was faster than that of food-bound K vitamins (serum peak values at 4 h vs. 6 h after ingestion). Moreover, circulating K(2) concentrations after the consumption of natto were about 10 times higher than those of K(1) after eating spinach. It is concluded that the contribution of K(2) vitamins (menaquinones) to the human vitamin K status is presently underestimated, and that their potential interference with oral anticoagulant treatment needs to be investigated.

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Crossref · 10.1159/000054147

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Metadata

Authors
Schurgers, L. J., & Vermeer, C.
Affiliations
Maastricht University (NL)
ORCID
Venue
Pathophysiology of Haemostasis and Thrombosis
Publisher
S. Karger AG
Published
2000
Volume
30
Issue
6
Pages
298-307
ISSN
  • 1424-8832 (ISSN-L)
  • 1424-8840
DOI
10.1159/000054147
OpenAlex
W2032942340
Cited by
397
References
33
Citations by year
2026: 12 · 2025: 12 · 2024: 17 · 2023: 18 · 2022: 23 · 2021: 37 · 2020: 28 · 2019: 24 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 20 · 2014: 16 · 2013: 20 · 2012: 24
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pathophysiology of Haemostasis and Thrombosis (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
vitamin K1, vitamin K2, vitamin K intake, food matrix, natto, spinach, oral anticoagulants, international normalized ratio

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