Prognosis of Alzheimer’s Disease: The Rotterdam Study
Abstract
The aim of this study was to construct a prognostic model to predict the progression of Alzheimer's disease (AD). Prevalent and incident cases with AD came from the Rotterdam Study, a population-based prospective cohort study of persons aged 55 years and older, including those living in institutions. Rate of cognitive decline, as measured by the Mini Mental State Examination (MMSE score), was predicted by a random effects model. Risk of institutionalization and death were estimated with polytomous logistic regression analysis. At baseline, 306 subjects were diagnosed with prevalent AD and had complete data on living conditions and cognitive function. After a mean follow-up of 2.1 years, 95 subjects with incident AD had been diagnosed. Prevalent patients showed a slower decline in cognitive function than incident patients (p = 0.004). For prevalent and incident AD patients, high age and low cognitive performance were the strongest predictors for institutionalization and death. These prognostic risk functions can provide information on the decline of Alzheimer patients and might be used to better evaluate the effect of treatments for AD.
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Most estimates of AD progression derive from convenience samples from dementia clinics or research centers, where there is substantial potential for survival bias and other distortions.
“Most estimates derive from convenience samples from dementia clinics or research centers where there is substantial potential for survival bias and other distortions.”
Survival bias may produce different estimates in prevalent vs. incident samples.
“so that survival bias may produce different estimates in prevalent vs. incident samples.(10)”
Cites
Incidence and Risk of Dementia: The Rotterdam study
Ott, A., Breteler, M. M. B., Harskamp, F. V., Stijnen, T., & Hofman, A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009489 · Cited by 455 · see citing works
Self-citationAgüero‐Torres, H., Fratiglioni, L., Guo, Z., Viitanen, M., & Winblad, B. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb02464.x · Cited by 147 · see citing works
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Tschanz, J. T., Corcoran, C. D., Schwartz, S., Treiber, K., Green, R. C., Norton, M. C., Mielke, M. M., Piercy, K., Steinberg, M., Rabins, P. V., et al. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181faec23 · Cited by 244 · see citing works
“incident samples.(10) Furthermore, few studies have examined cognition, function, and NPS simultaneously, so their descriptions of AD progression are incomplete.”
Background
- Authors
- Ruitenberg, A., Kalmijn, S., de Ridder, M. A. J., Redekop, W. K., van Harskamp, F., Hofman, A., Launer, L. J., & Breteler, M. M. B.
- Affiliations
- Erasmus University Rotterdam (NL)
- National Institute for Public Health and the Environment (NL)
- Venue
- Neuroepidemiology
- Publisher
- S. Karger AG
- Published
- 2001
- Volume
- 20
- Issue
- 3
- Pages
- 188-195
- ISSN
- 0251-5350 (ISSN-L)
- 1423-0208
- OpenAlex
- W2062991123
- Cited by
- 41
- References
- 2
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroepidemiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Keywords
- Alzheimer's disease, disease progression, prognostic model, cognitive decline, Mini-Mental State Examination, institutionalization, mortality, risk factors, older adults, Rotterdam Study
- MeSH terms
- Activities of Daily Living, Aged, Alzheimer Disease, Cognition Disorders, Female, Humans, Male, Mental Status Schedule, Middle Aged, Prognosis, Prospective Studies, Cohort Studies, Prevalence
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