Protective effects of (−)-epigallocatechin-3-gallate on UVA- and UVB-induced skin damage
Abstract
It has been known that green tea and its components possess significant chemopreventive effects against chemical carcinogens and photo-caused skin tumor formation. In this study, the protective effects of (–)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the ultraviolet (UV)-induced skin damage (photoaging) were studied in guinea pigs, hairless mice and human dermal fibroblast cultures. The lipid peroxidation was significantly reduced in the EGCG-treated group. The amount of lipid peroxides produced in the control and EGCG treated group were 838 ± 144 and 286 ± 57 nmol/mg at 18 h after UV irradiation, respectively. UVB-induced erythema was also significantly reduced in the EGCG treated group. The erythema relative index of the control and the EGCG treated group were 311 ± 45 and 191 ± 49 at 16 h after UV irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagen secretion and collagenase mRNA level in fibroblast culture. The nuclear transcription factors NF-ĸB and AP-1 binding activities were also inhibited by EGCG treatment.
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Green tea polyphenols protect against erythema.
“| Green tea polyphenols | Polyphenolic | Erythema | + | + | (112,113,114) |”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [114]
Green tea polyphenols protect against photoaging.
“| (epigallocatechin), | | Photoaging | | + | (114) |”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [114]
When human fibroblasts were treated with epigallocatechin-3-gallate in culture, it effectively prevented the UV-induced rise in collagen secretion and collagenase mRNA levels.
“Furthermore, research studies have indicated that when human fibroblasts were treated with epigallocatechin-3-gallate in culture, it effectively prevented the UV-induced rise in collagen secretion and collagenase mRNA levels.”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Kim et al. 2001
Epigallocatechin-3-gallate was found to regulate mitogen-activated protein kinase signaling pathways.
“Moreover, epigallocatechin-3-gallate was found to regulate mitogen-activated protein kinase signaling pathways (Kim et al. 2001).”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Kim et al. 2001
Epigallocatechin-3-gallate demonstrated the ability to inhibit the binding activities of nuclear transcription factors NF-κB and activated protein (AP)-1, both induced by UV exposure.
“Additionally, it demonstrated the ability to inhibit the binding activities of nuclear transcription factors NF-κB (nuclear factor kappa light chain enhancer of activated B cells) and activated protein (AP)-1, both induced by UV exposure.”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Kim et al. 2001
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References 37 · Cited by 134
- Authors
- Kim, J., Hwang, J.-S., Cho, Y.-K., Han, Y., Jeon, Y.-J., & Yang, K.-H.
- Affiliations
- Amorepacific (South Korea) (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Venue
- Skin Pharmacology and Physiology
- Publisher
- S. Karger AG
- Published
- 2001
- Volume
- 14
- Issue
- 1
- Pages
- 11-19
- ISSN
- 1422-2868 (ISSN-L)
- 1660-5527
- 1660-5535
- OpenAlex
- W1978949356
- Cited by
- 134
- References
- 37
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 3
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Skin Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- epigallocatechin gallate, green tea catechins, UV-induced skin damage, photoaging, UVA, UV-B radiation, lipid peroxidation, erythema, skin collagen, collagenase, dermal fibroblasts, NF-κB, AP-1
- MeSH terms
- Animals, Catechin, Cells, Cultured, Collagen, Electrophoresis, Erythema, Female, Fibroblasts, Guinea Pigs, Immunohistochemistry, Mice, Hairless, Radiation-Protective Agents, RNA, Messenger, Skin, Ultraviolet Rays, Lipid Peroxidation, NF-kappa B, Mice
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