Cited by 207Mast cells and histamineEosinophilic Disorders and SyndromesHistiocytic Disorders and Treatments

Serum tryptase levels in patients with mastocytosis: Correlation with mast cell burden and implication for defining the category of disease

Sperr, Wolfgang R., Jordan, John-Hendrik, Fiegl, Michael, Escribano, Luis, Bellas, Carmen, Dirnhofer, Stephan, Semper, Hans, Simonitsch-Klupp, Ingrid +2 more·2002·International Archives of Allergy and Immunology

Abstract

BACKGROUND: The serum tryptase level is used as a diagnostic marker in mastocytosis and is considered to reflect the burden of (neoplastic) mast cells (MC). METHODS: In the present study, serum tryptase levels were measured in patients with mastocytosis by fluoroenzyme immunoassay and compared with the extent of infiltration of the bone marrow (BM) by neoplastic MC, determined by tryptase immunohistochemistry. Sixteen patients with cutaneous mastocytosis (CM) and 43 patients with systemic mastocytosis (SM) were examined. RESULTS: In most patients with CM (defined by the absence of dense compact MC infiltrates in tryptase-stained BM sections), normal or near-normal serum tryptase levels (median 10 ng/ml, range 2-23 ng/ml) were measured. By contrast, in the vast majority of patients with SM, elevated serum tryptase levels (median 67 ng/ml) were found. In addition, there was a significant correlation between the grade of infiltration of the BM by neoplastic MC and tryptase levels in patients with SM (r = 0.8). Moreover, enzyme levels differed significantly among the groups of patients with different types of SM. The highest levels (>900 ng/ml) were detected in the patient with MC leukemia, 2 patients with slowly progressing SM and high MC burden (smoldering SM) and 1 patient with indolent SM. In contrast, in all 3 patients with isolated BM mastocytosis (no skin lesions and no signs of multiorgan involvement), serum tryptase levels were <20 ng/ml. CONCLUSIONS: In summary, our data suggest that the measurement of serum tryptase is a reliable noninvasive diagnostic approach to estimate the burden of MC in patients with mastocytosis and to distinguish between categories of disease.

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Crossref · 10.1159/000059404

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  • Tryptase is correlated with disease severity since tryptase serves as a B-finding if it is above 200 ng/mL (adjusted for TPSAB1 status).

    “It is however correlated with disease severity since tryptase serves a B-finding if it is above 200 ng/mL (adjusted for the TPSAB1 status) [56,72].”

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Authors
Sperr, W. R., Jordan, J.-H., Fiegl, M., Escribano, L., Bellas, C., Dirnhofer, S., Semper, H., Simonitsch-Klupp, I., Horny, H.-P., & Valent, P.
Affiliations
  • University of Vienna (AT)
  • Hospital Universitario Ramón y Cajal (ES)
  • Universität Innsbruck (AT)
  • University of Lübeck (DE)
Venue
International Archives of Allergy and Immunology
Publisher
S. Karger AG
Published
2002
Volume
128
Issue
2
Pages
136-141
ISSN
  • 1018-2438 (ISSN-L)
  • 1423-0097
OpenAlex
W2085568341
Cited by
207
References
33
Citations by year
2026: 2 · 2025: 5 · 2024: 11 · 2023: 18 · 2022: 6 · 2021: 15 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 5 · 2016: 7 · 2015: 12 · 2014: 18 · 2013: 6 · 2012: 8
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Locations
  • International Archives of Allergy and Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Austrian Science Fund
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Rheumatology › Eosinophilic Disorders and Syndromes
  • Health Sciences › Medicine › Physiology › Histiocytic Disorders and Treatments
Keywords
serum tryptase, mastocytosis, systemic mastocytosis, cutaneous mastocytosis, bone marrow involvement, mast cell leukemia, diagnostic biomarkers, disease classification
MeSH terms
Adolescent, Adult, Aged, Biopsy, Bone Marrow, Child, Female, Humans, Immunohistochemistry, Male, Mast Cells, Mastocytosis, Middle Aged, Regression Analysis, Retrospective Studies, Serine Endopeptidases, Statistics, Nonparametric, Bone Marrow Neoplasms, Tryptases

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