Cited by 36Mast cells and histamineFood Allergy and Anaphylaxis ResearchAsthma and respiratory diseases

Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review

Lee, Adrian Y.S.·2020·International Archives of Allergy and Immunology

Abstract

One of the most important blood tests in the field of allergy, mast cell tryptase has numerous diagnostic uses, particularly for anaphylactic reactions and for the diagnosis of mastocytosis. However, there are numerous other non-anaphylactic conditions where clinicians may see elevated serum tryptase (hypertryptasemia) and the practicing clinician ought to be aware of these important differential diagnoses. Such conditions include systemic mastocytosis, hematological malignancies, and chronic kidney disease. This article provides a comprehensive, updated summary on the variety of non-anaphylactic conditions where hypertryptasemia may be seen.

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Crossref · 10.1159/000506199

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79 of 79 references verified0 citation errors · 0 not checkable

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Authors
Lee, A. Y. S.
Affiliations
South Australia Pathology (AU)
Corresponding author
Lee, Adrian Y.S.
Venue
International Archives of Allergy and Immunology
Publisher
S. Karger AG
Published
2020
Volume
181
Issue
5
Pages
357-364
ISSN
  • 1018-2438 (ISSN-L)
  • 1423-0097
OpenAlex
W3009260631
Cited by
36
References
79
Citations by year
2025: 1 · 2024: 12 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 2
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Locations
  • International Archives of Allergy and Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
serum tryptase, differential diagnosis, systemic mastocytosis, hematologic malignancies, chronic kidney disease, mast cells, anaphylaxis
MeSH terms
Humans, Tryptases

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