Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review
Abstract
One of the most important blood tests in the field of allergy, mast cell tryptase has numerous diagnostic uses, particularly for anaphylactic reactions and for the diagnosis of mastocytosis. However, there are numerous other non-anaphylactic conditions where clinicians may see elevated serum tryptase (hypertryptasemia) and the practicing clinician ought to be aware of these important differential diagnoses. Such conditions include systemic mastocytosis, hematological malignancies, and chronic kidney disease. This article provides a comprehensive, updated summary on the variety of non-anaphylactic conditions where hypertryptasemia may be seen.
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Several reasons other than SM can increase BST, including pregnancy, chronic kidney disease, other myeloid neoplasms and HαT.
“several reasons other than SM can increase BST, including pregnancy, chronic kidney disease, other myeloid neoplasms and HαT (27).”
From Defining “Normal” basal serum tryptase levels: a context-dependent approach to improve diagnostics in systemic mastocytosis (2025) · cites this paper as [27]
Elevated tryptase can be found in chronic kidney disease, obesity, and hematological neoplasms.
“Elevated tryptase can also be found in chronic kidney disease, obesity, and hematological neoplasms.”
From Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders (2023) · cites this paper as [78]
Helminthic infections, hematological malignancies, cardiovascular disease, (nummular) eczema, or rare genetic mutations (e.g., GATA2 or PLAID) can cause elevated baseline serum tryptase.
“Moreover, obesity can be a cause of elevated bST [77], as well as helminthic infections, hematological malignancies, cardiovascular disease, (nummular) eczema, or rare genetic mutations (e.g., GATA2 or PLAID) [8,78,79].”
From Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders (2023) · cites this paper as [78]
BST can be elevated due to non-SM related diseases as well as HαT.
“BST can be elevated also due to non-SM related diseases as well as hereditary alpha-tryptasemia (HαT)”
From Defining “Normal” basal serum tryptase levels: a context-dependent approach to improve diagnostics in systemic mastocytosis (2025) · cites this paper as [27]
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“Moreover, obesity can be a cause of elevated bST [77], as well as helminthic infections, hematological malignancies, cardiovascular disease, (nummular) eczema, or rare genetic mutations (e.g., GATA2 or PLAID) [8,78,79].”
BackgroundCrupi, F., Caroprese, J., & Mannelli, F. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1592001 · Cited by 2 · see citing works
- Authors
- Lee, A. Y. S.
- Affiliations
- South Australia Pathology (AU)
- Corresponding author
- Lee, Adrian Y.S.
- ORCID
- Lee, Adrian Y.S.
- Venue
- International Archives of Allergy and Immunology
- Publisher
- S. Karger AG
- Published
- 2020
- Volume
- 181
- Issue
- 5
- Pages
- 357-364
- ISSN
- 1018-2438 (ISSN-L)
- 1423-0097
- OpenAlex
- W3009260631
- Cited by
- 36
- References
- 79
- Citations by year
- 2025: 1 · 2024: 12 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Archives of Allergy and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- serum tryptase, differential diagnosis, systemic mastocytosis, hematologic malignancies, chronic kidney disease, mast cells, anaphylaxis
- MeSH terms
- Humans, Tryptases
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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