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Red Wine Ingredient Resveratrol Protects from β-Amyloid Neurotoxicity
Open accessAbstract
Background: β-Amyloid peptide (Aβ), a neutrotoxic substance, has been implicated to a great degree in cell death during the course of AD. Resveratrol, a natural polyphenol mainly found in red wine, has been shown to be cardioprotective and chemoprotective. Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol. Objective: The present study aimed at elucidating the possible neuroprotective effects of resveratrol against Aβ-induced neurotoxicity. Methods: The neuroprotective capacity against Aβ-related oxidative stress was studied in a cell culture model suitable for studying such potentially neuroprotective substances. Results: Resveratrol maintains cell viability and exerts an anti-oxidative action by enhancing the intracellular free-radical scavenger glutathione. Conclusion: Our findings suggest that red wine may be neuroprotective through the actions of resveratrol.
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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
The MAPK cascade is required for mammalian associative learning
Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083
Cited by
Porat, Y., Abramowitz, A., & Gazit, E. (2006) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2005.00318.x · Cited by 989
Buendia, I., Michalska, P., Navarro, E., Gameiro, I., Egea, J., & León, R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 678
Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease
M. de la Monte, S. (2012) · Current Alzheimer Research · doi:10.2174/156720512799015037 · Cited by 448
Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426
Resveratrol—A boon for treating Alzheimer's disease?
Anekonda, T. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.004 · Cited by 339
Metadata
- Authors
- Savaskan, E., Olivieri, G., Meier, F., Seifritz, E., Wirz-Justice, A., & Müller-Spahn, F.
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 49
- Issue
- 6
- Pages
- 380-383
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2022057811
- Cited by
- 182
- References
- 2
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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