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Combined (Thalamotomy and Stimulation) Stereotactic Surgery of the VIM Thalamic Nucleus for Bilateral Parkinson Disease
Abstract
Stereotactic thalamotomy of the thalamic nucleus ventralis intermedius (VIM) is routinely used for movement disorders. During this procedure, it has been observed that high-frequency (100 Hz) stimulation of VIM was able to stop the extrapyramidal tremor. In patients with bilateral tremor of extrapyramidal origin, who were resistant to drug therapy, the therapeutic protocol associated (1) a radiofrequency VIM thalamotomy for the most disabled side, and (2) a continuous VIM stimulation for the other side using stereotactically implanted electrodes, connected to subcutaneous stimulators. VIM thalamotomy relieved the tremor in all operated cases. Side effects were mild and regressive, VIM stimulation strongly decreasedthe tremor but failed to suppress it as completely as thalamotomy did. This was due in part to the fact that programmable stimulator frequency rate is limited to 130 Hz, while it appeared that the optimal stimulation frequency was 200 Hz. This therapeutic protocol appears to be of interest for patients with bilateralextrapyramidal movement disorders.
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Citations
Cited by
Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus
Benabid, A. L., Pollak, P., Hoffmann, D., Gervason, C., Hommel, M., Perret, J. E., de Rougemont, J., & Gao, D. M. (1991) · The Lancet · doi:10.1016/0140-6736(91)91175-t · Cited by 1,787
Self-citationDeep brain stimulation: current challenges and future directions
Lozano, A. M., Lipsman, N., Bergman, H., Brown, P., Chabardes, S., Chang, J. W., Matthews, K., McIntyre, C. C., Schlaepfer, T. E., Schulder, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0128-2 · Cited by 1,450
Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.242 · Cited by 1,190
Translational principles of deep brain stimulation
Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853
Probing and regulating dysfunctional circuits using deep brain stimulation
Lozano, A. M., & Lipsman, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.020 · Cited by 665
Metadata
- Authors
- Benabid, A. L., Pollak, P., Louveau, A., Henry, S., & de Rougemont, J.
- Venue
- Stereotactic and Functional Neurosurgery
- Publisher
- S. Karger AG
- Published
- 1987
- Volume
- 50
- Issue
- 1-6
- Pages
- 344-346
- ISSN
- 1011-6125 (ISSN-L)
- 1423-0372
- OpenAlex
- W2082851956
- Cited by
- 1,378
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Benabid, A. L., Pollak, P., Louveau, A., Henry, S., & de Rougemont, J. (1987). Combined (Thalamotomy and Stimulation) Stereotactic Surgery of the VIM Thalamic Nucleus for Bilateral Parkinson Disease. Stereotactic and Functional Neurosurgery. https://doi.org/10.1159/000100803
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