Factors regulating trophoblast invasion.
Open accessAbstract
Implantation in the human is unique. This uniqueness is characterized on the maternal side by a spontaneous and massive decidualization of the endometrium and on the embryonic side by an almost unlimited invasive potential. Human embryos express an intrinsic invasive potential, which allows them to implant almost anywhere except in the endometrium because it protects itself from implantation. Human implantation is thus only possible during a limited period of time known as the implantation window. This mini review stresses the importance of studying trophoblast invasion into the endometrium as a model for human implantation. Cytotrophoblastic cells (CTB) can easily be isolated from first-trimester legal abortions and retain their invasive behavior when cultured in vitro. This model shows that matrix metalloproteinases (MMPs) are produced by CTB and are instrumental to their invasive behavior. Embryo implantation and tumor invasion use these same biochemical mediators for invasion. However, in contrast to tumor invasion, trophoblast invasion is limited both in time and space: it occurs during the first trimester of pregnancy and invasion does not go beyond the proximal third of the myometrium. Factors regulating MMP expression are of maternal and fetal origin.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Implantation involves embryo apposition and adhesion to the endometrial epithelium followed by penetration through the epithelium and invasion of the embryonic trophoblast through the endometrial stroma, which require extracellular matrix degradation.
“Implantation involves embryo apposition and adhesion to the endometrial epithelium followed by penetration through the epithelium and invasion of the embryonic trophoblast through the endometrial stroma, which require extra cellular matrix degradation [46].”
From Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation (2010) · cites this paper as [46]
Cites
Activation mechanisms of matrix metalloproteinases.
Nagase, H. (1997) · PubMed · Cited by 1,124 · see citing works
Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy
Pijnenborg, R., Dixon, G., Robertson, W. B., & Brosens, I. A. (1980) · Placenta · doi:10.1016/s0143-4004(80)80012-9 · Cited by 848 · see citing works
92-kD type IV collagenase mediates invasion of human cytotrophoblasts.
Librach, C. L., Werb, Z., Fitzgerald, M. L., Chiu, K., Corwin, N., Esteves, R. A., Grobelny, D. W., Galardy, R. E., Damsky, C. H., & Fisher, S. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.2.437 · Cited by 718 · see citing works
Experimental metastasis is suppressed in MMP-9-deficient mice
Itoh, T., Tanioka, M., Matsuda, H., Nishimoto, H., Yoshioka, T., Suzuki, R., & Uehira, M. (1999) · Clinical & Experimental Metastasis · doi:10.1023/a:1006603723759 · Cited by 308 · see citing works
Shimonovitz, S., Hurwitz, A., Dushnik, M., et al. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(94)90107-4 · Cited by 194 · see citing works
The human cytotrophoblastic cell, a mononuclear chameleon
Bischof, P., & Irminger‐Finger, I. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.014 · Cited by 182 · see citing works
Self-citationPreimplantation development of the mammalian embryo and its regulation by growth factors
Stewart, C. L., & Cullinan, E. B. (1997) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1997)21:1 · Cited by 136 · see citing works
Kao, L.-C., Caltabiano, S., Wu, S., Strauss, J. F., & Kliman, H. J. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90361-2 · Cited by 131 · see citing works
Fine structure of anchoring villi of the human placenta
Enders, A. C. (1968) · American Journal of Anatomy · doi:10.1002/aja.1001220302 · Cited by 90 · see citing works
The Role of Integrins in Human Embryo Implantation
Merviel, P., Challier, J.-C., Carbillon, L., et al. (2001) · Fetal Diagnosis and Therapy · doi:10.1159/000053942 · Cited by 73 · see citing works
Expression of gelatinase B by trophoblast cells: Down-regulation by progesterone
Shimonovitz, S., Hurwitz, A., Hochner‐Celnikier, D., et al. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70420-x · Cited by 59 · see citing works
Trophectoderm biogenesis in the preimplantation mouse embryo
Fleming, T. P. (1992) · Springer eBooks · doi:10.1007/978-94-011-2354-9_4 · Cited by 26 · see citing works
Oktay, K., Brzyski, R. G., Miller, E., et al. (1994) · PubMed · Cited by 25 · see citing works
Chaouat, G., Lédée, N., Chea, K. B., et al. (2005) · KARGER eBooks · doi:10.1159/000087820 · Cited by 20 · see citing works
The relation between depth of trophoblastic invasion and ?-HCG levels in tubal pregnancies
Klein, M. U., Graf, A.-H., Kiss, H., et al. (1995) · Archives of Gynecology and Obstetrics · doi:10.1007/bf00634713 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Evolution, Regulation, and Function of Placenta-Specific Genes
Rawn, S. M., & Cross, J. C. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175418 · Cited by 222 · see citing works
Jensen, F., Woudwyk, M., Teles, A., Woidacki, K., Taran, F., Costa, S., Malfertheiner, S. F., & Zenclussen, A. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014409 · Cited by 145 · see citing works
“Implantation involves embryo apposition and adhesion to the endometrial epithelium followed by penetration through the epithelium and invasion of the embryonic trophoblast through the endometrial stroma, which require extra cellular matrix degradation [46].”
Background
- Authors
- Cohen, M., & Bischof, P.
- Affiliations
- University of Geneva (CH)
- ORCID
- Cohen, Marie
- Venue
- Gynecologic and Obstetric Investigation
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 64
- Issue
- 3
- Pages
- 126-130
- ISSN
- 0378-7346 (ISSN-L)
- 1423-002X
- OpenAlex
- W2009505821
- Cited by
- 103
- References
- 15
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 10
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- Locations
- Gynecologic and Obstetric Investigation (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- trophoblast invasion, embryo implantation, matrix metalloproteinases, cytotrophoblast, endometrial decidualization, implantation window, first-trimester abortion, tumor invasion, myometrium
- MeSH terms
- Female, Humans, Neoplasm Invasiveness, Embryo Implantation, Pregnancy, Trophoblasts, Tissue Inhibitor of Metalloproteinases, Matrix Metalloproteinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
