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Validity of Dementia Diagnoses in the Danish Hospital Registers
Abstract
Background:The validity of dementia diagnoses in the Danish nationwide hospital registers was evaluated to determine the value of these registers in epidemiological research about dementia. Methods: Two hundred patients were randomly selected from 4,682 patients registered for the first time with a dementia diagnosis in the last 6 months of 2003. The patients’ medical journals were reviewed to evaluate if they fulfilled ICD-10 and/or DSM-IV criteria for dementia and specific dementia subtypes. The patients who were still alive in 2006 were invited to an interview. Results: One hundred and ninety-seven journals were available for review and 51 patients were interviewed. A registered diagnosis of dementia was found to be correct in 169 (85.8%) cases. Regarding dementia subtypes, the degree of agreement between the registers and the results of the validating process was low with a kappa of 0.36 (95% CI 0.24–0.48). Conclusion: The validity of dementia syndrome in the Danish hospital registers was high and allows for epidemiological studies about dementia. Alzheimer’s disease, although underregistered, also had a good validity once the diagnosis was registered. In general, other ICD-10 dementia subtypes in the registers had a low validity and are less suitable for epidemiological research.
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“One potential limitation concerns the validity of the dementia diagnoses; however, the national Danish Patient Registry includes all hospital visits, and dementia diagnoses in the Danish registries have high diagnostic validity 19 , 44 ; any unregistered events would only lead to decreased power of estimates and bias results toward the null hypothesis.”
From APOE and dementia – resequencing and genotyping in 105,597 individuals (2020) · cites this paper as [44]
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“Dementia diagnoses in the Danish registries have high diagnostic validity.24,76”
From Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort (2019) · cites this paper as [76]
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Metadata
- Authors
- Phung, T. K. T., Andersen, B. B., Høgh, P., Kessing, L. V., Mortensen, P. B., & Waldemar, G.
- Affiliations
- Copenhagen University Hospital (DK)
- Aarhus University Hospital (DK)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 24
- Issue
- 3
- Pages
- 220-228
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2124969446
- Cited by
- 279
- References
- 32
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 20 · 2023: 14 · 2022: 24 · 2021: 27 · 2020: 25 · 2019: 20 · 2018: 18 · 2017: 16 · 2016: 20 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 7
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- H. Lundbeck A/S
- Fondation pour la Recherche sur Alzheimer
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Health Professions › Health Information Management › Medical Coding and Health Information
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
- Keywords
- dementia, diagnostic validity, hospital registers, ICD-10, DSM-IV, Alzheimer's disease, dementia subtypes
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Denmark, Female, Humans, Interview, Psychological, Male, Medical Records, Neuropsychological Tests, Psychiatric Status Rating Scales, Registries, Reproducibility of Results
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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