Nanoparticle-Based Oral Drug Delivery System for an Injectable Antibiotic – Streptomycin
Abstract
Background: To develop an oral drug delivery system for an injectable antibiotic, streptomycin. Methods: Poly-lactide-co-glycolide (PLG) nanoparticles encapsulating streptomycin were prepared by the multiple emulsion technique and administered orally to mice for biodistribution and chemotherapeutic studies. Results: The mean particle size was 153.12 nm with 32.12 ± 4.08% drug encapsulation and 14.28 ± 2.83% drug loading. Streptomycin levels were maintained for 4 days in the plasma and for 7 days in the organs following a single oral administration of PLG nanoparticles. There was a 21-fold increase in the relative bioavailability of PLG-encapsulated streptomycin compared with intramuscular free drug. In Mycobacterium tuberculosis H 37 Rv infected mice, eight doses of the oral streptomycin formulation administered weekly were comparable to 24 intramuscular injections of free streptomycin. Further, the nanoparticle formulation did not result in nephrotoxicity as assessed on a biochemical basis. Conclusion: Our results suggest that nanoencapsulation might be useful for developing a suitable oral dosage form for streptomycin and perhaps for other antibiotics that are otherwise injectable.
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Polymer-based nanoparticles (PLGA and sodium alginate) have been developed to improve the oral bioavailability of rifampicin, isoniazid, ethambutol, pyrazinamide and streptomycin.
“Polymer-based nanoparticles (PLGA and sodium alginate) have also been developed to improve the oral bioavailability of rifampicin, isoniazid, ethambutol, pyrazinamide and streptomycin 124-127 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [125]
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- Authors
- Pandey, R., & Khuller, G. K.
- Affiliations
- Post Graduate Institute of Medical Education and Research (IN)
- ORCID
- Pandey, Rajesh
- Venue
- Chemotherapy
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 53
- Issue
- 6
- Pages
- 437-441
- ISSN
- 0009-3157 (ISSN-L)
- 1421-9794
- OpenAlex
- W2094397842
- Cited by
- 80
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 1 · 2017: 7 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 4
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- streptomycin, oral drug delivery, injectable antibiotics, PLGA nanoparticles, poly(lactic-co-glycolic acid), nanoparticle encapsulation, relative bioavailability, Mycobacterium tuberculosis H37Rv, tuberculosis chemotherapy, nephrotoxicity, tissue distribution
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Administration, Oral, Animals, Anti-Bacterial Agents, Disease Models, Animal, Female, Male, Mice, Inbred Strains, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Plasma, Polyglycolic Acid, Polymers, Streptomycin, Tuberculosis, Drug Delivery Systems, Lactic Acid, Nanostructures, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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