Cited by 201Estrogen and related hormone effectsNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 125 of the 128 references it cites were found in a registry or an index.

Rapid Estrogen Signaling in the Brain

Raz, Limor, Khan, Mohammad M., Mahesh, Virendra B., Vadlamudi, Ratna K., Brann, Darrell W.·2008·Neurosignals

DOI 10.1159/000111559

Open this paper in CoChat — free account

Abstract

Estrogen has multiple actions in the brain to modulate homeostasis, synaptic plasticity/cognition and neuroprotection. While many of these actions undoubtedly involve mediation via the classical genomic mechanism of regulation of transcription of genes via estrogen nuclear receptors, there has been growing interest in the rapid nongenomic effects of estrogen and the role they may play in the neural actions of estrogen. In this review, we will focus on these rapid nongenomic actions of estrogen in the brain and discuss the potential physiological significance of these actions. The evidence for rapid estrogen regulation of cell signaling pathways, including calcium, ion channel and kinase signaling pathways in the brain will be reviewed, as will evidence derived from plasma-membrane impermeable estrogen-peptide conjugates in the regulation of these cell signaling pathways. Evidence supporting classical and nonclassical estrogen receptor localization to the plasma membrane of neurons will also be reviewed, including the putative new membrane estrogen G-protein-coupled receptor, GPR30. Precisely how membrane estrogen receptors couple to kinase signaling pathways is unclear, but we will discuss the latest findings on estrogen receptor-interacting scaffold proteins, such as MNAR/PELP1, striatin and p130Cas, which are capable of linking estrogen receptors and kinases such as Src and PI3K, to potentially mediate estrogen-induced kinase signaling. Finally, we will review the growing evidence that rapid membrane-mediated effects of estrogen play an important physiological role in the neural actions of estrogen in the brain, including estrogen feedback control and modulation of homeostasis, regulation of synaptic plasticity/cognition, and estrogen-mediated neuroprotection.

Integrity signals

Registry

Crossref · 10.1159/000111559

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

2 retracted

RETRACTED: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade
Wong, C., McNally, C., Nickbarg, E., Komm, B. S., & Cheskis, B. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192569699 · Cited by 321
Retracted
RETRACTED ARTICLE: Phosphorylation of MNAR Promotes Estrogen Activation of Phosphatidylinositol 3-Kinase
Greger, J., Fursov, N., Cooch, N. S., McLarney, S., Freedman, L. P., Edwards, D. P., & Cheskis, B. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01732-06 · Cited by 54
Retracted
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302
Estrogen Actions in the Central Nervous System
McEwen, B. S., & Alves, S. E. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0365 · Cited by 1,504
Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
Thomas, P., Pang, Y., Filardo, E. J., & Dong, J. (2004) · Endocrinology · doi:10.1210/en.2004-1064 · Cited by 1,410
Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF
Filardo, E. J., Quinn, J. A., Bland, K. I., & Frackelton, A. R. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.10.0532 · Cited by 1,387
The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling
Hall, J. M., Couse, J. F., & Korach, K. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100029200 · Cited by 1,202
Skeletal Effects of Estrogen*
Turner, R. T., Riggs, B. L., & Spelsberg, T. C. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-275 · Cited by 758
Integration of the extranuclear and nuclear actions of estrogen
Levin, E. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0390 · Cited by 708
Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications
Brann, D. W., Dhandapani, K. M., Wakade, C. G., Mahesh, V. B., & Khan, M. M. (2007) · Steroids · doi:10.1016/j.steroids.2007.02.003 · Cited by 677
Self-citation

Flagged first, then by citations

Show all 128 references

3 of the 128 references couldn’t be matched to a known paper.

Research works printed but not linked: 9

Brann DW, Mills TM, Mahesh VB: Female reproduction: the ovulatory cycle; in Witorsch RJ (ed): Reproductive Toxicology, ed 2. New York, Raven Press, 1995, pp 23-44.
Kelly MJ, 1977, Exp Brain Res, 30, 53
Kelly MJ, 1977, Exp Brain Res, 30, 43
Smith S: The effects of estrogen and progesterone on GABA and glutamate responses at extrahypothalmic sites; in Costa E, Paul S: Neurosteroids and Brain Function. New York, Thieme Medical Publishers, 1991, pp 87-94.
10.1210/en.138.9.4030 · DOI
10.1046/j.1460-9568.1998.00045.x · DOI
10.1210/en.140.11.5455 · DOI
10.1210/me.14.10.1649 · DOI
10.1210/me.16.1.100 · DOI

Sorted by citations

Items 101–200 of 201

17Beta-estradiol differentially protects cortical pericontusional zone from programmed cell death after traumatic cerebral contusion at distinct stages via non-genomic and genomic pathways
Bao, Y.-J., Li, L.-Z., Li, X.-G., & Wang, Y.-J. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.07.004 · Cited by 30
Estradiol induces JNK-dependent apoptosis in glioblastoma cells
Altıok, N., Ersöz, M., & Koyutürk, M. (2011) · Oncology Letters · doi:10.3892/ol.2011.385 · Cited by 30
Beyond Hot Flashes: The Role of Estrogen Receptors in Menopausal Mental Health and Cognitive Decline
Cho, J. M., Lee, J., Ahn, E., & Bae, J.-W. (2025) · Brain Sciences · doi:10.3390/brainsci15091003 · Cited by 29
Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism
Small, K. M., Nag, S., & Mokha, S. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.034 · Cited by 29
Rapid signaling of steroid hormones in the vertebrate nervous system
Sakamoto, H. (2011) · Frontiers in bioscience · doi:10.2741/3970 · Cited by 30
Estrogen Receptors: Their Actions and Functional Roles in Health and Disease
Nilsson, S. V., & Gustafsson, J.-Α. (2010) · Springer eBooks · doi:10.1007/978-90-481-3303-1_5 · Cited by 31
Distinct Function of Estrogen Receptors in the Rodent Anterior Cingulate Cortex in Pain-related Aversion
Zang, K., Xiao, X., Chen, L., Yang, Y. L., Cao, Q.-L., Tang, Y.-L., Lv, S., Cao, H., Zhang, L., & Zhang, Y. (2020) · Anesthesiology · doi:10.1097/aln.0000000000003324 · Cited by 28
Discovery of Selective Probes and Antagonists for G Protein-Coupled Receptors FPR/FPRL1 and GPR30
Arterburn, J. B., Oprea, T. I., Prossnitz, E. R., Edwards, B. S., & Sklar, L. A. (2009) · Current Topics in Medicinal Chemistry · doi:10.2174/156802609789753608 · Cited by 28
In vitro effects of bisphenol A on developing hypothalamic neurons
Iwakura, T., Iwafuchi, M., Muraoka, D., Yokosuka, M., Shiga, T., Watanabe, C., & Ohtani‐Kaneko, R. (2010) · Toxicology · doi:10.1016/j.tox.2010.04.005 · Cited by 28
17β-Estradiol-induced enhancement of estrogen receptor biosynthesis via MAPK pathway in mouse skeletal muscle myoblasts
Hatae, J., Takami, N., Lin, H., Honda, A., & Inoue, R. (2009) · The Journal of Physiological Sciences · doi:10.1007/s12576-009-0023-0 · Cited by 27
Estradiol accelerates the effects of fluoxetine on serotonin 1A receptor signaling
Li, Q., Sullivan, N. R., McAllister, C. E., de Kar, L. D. V., & Muma, N. A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.005 · Cited by 26
The estrogen receptor: two or more molecules, multiple variants, diverse localizations, signaling and functions. Are we undergoing a paradigm-shift as regards their significance in breast cancer?
Kampa, M., Pelekanou, V., Notas, G., Stathopoulos, E. N., & Castanas, E. (2013) · HORMONES · doi:10.1007/bf03401288 · Cited by 27
Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy
Wang, L., Yokoyama, K. K., Chen, T., Hsiao, H.-W., Chiang, P.-C., Hsieh, Y., Lo, S. J., & Hsu, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131224 · Cited by 25
Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals
Scarduzio, M., Panichi, R., Pettorossi, V. E., & Grassi, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080792 · Cited by 24
Influence of sex and estrous cycle on synaptic responses of the medial vestibular nuclei in rats: Role of circulating 17β-estradiol
Grassi, S., Frondaroli, A., Scarduzio, M., Dieni, C. V., Brecchia, G., Boiti, C., & Pettorossi, V. E. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.008 · Cited by 23
Isolation and cultivation of mesenchymal stem cells from iliac crest bone marrow for further cartilage defect management.
Lubis, A. M. T., Sandhow, L., Lubis, V. K., Noor, A., Gumay, F., Merlina, M., Yang, W., Kusnadi, Y., Lorensia, V., Sandra, F., et al. (2011) · PubMed · Cited by 25
GPR30 Differentially Regulates Short Latency Responses of Luteinising Hormone and Prolactin Secretion to Oestradiol
Lebesgue, D., Reyna‐Neyra, A., Huang, X., & Etgen, A. M. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01893.x · Cited by 23
Oestrogen: an overlooked mediator in the neuropsychopharmacology of treatment response?
Keating, C., Tilbrook, A. J., & Kulkarni, J. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000982 · Cited by 24
The Arcuate Estrogen-Regulated Transcriptome: Estrogen Response Element–Dependent and –Independent Signaling of ERα in Female Mice
Yang, J., Stires, H., Belden, W. J., & Roepke, T. A. (2017) · Endocrinology · doi:10.1210/en.2016-1663 · Cited by 22
17β-Estradiol Modulates Gene Expression in the Female Mouse Cerebral Cortex
Humphreys, G. I., Ziegler, Y., & Nardulli, A. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111975 · Cited by 24
Physiological and biochemical effects of 17β estradiol in aging female rat brain
Kumar, P., Taha, A., Kale, R. K., Cowsik, S. M., & Baquer, N. Z. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.02.008 · Cited by 22
Estrogen potentiates prostaglandin E2-stimulated duodenal mucosal HCO3− secretion in mice
Tuo, B., Wen, G., Wang, X., Xu, J., Xie, R., Liu, X., & Dong, H. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00575.2011 · Cited by 20
Oestrogens as M odulators of N euronal Si gnalosomes and B rain L ipid H omeostasis R elated to P rotection A gainst N eurodegeneration
Marín, R., Casañas‐Sánchez, V., Pérez, J. A. P., Fabelo, N., Fernandez, C. E., & Díaz, M. L. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12068 · Cited by 20
Response of ERβ and aromatase expression in the monkey hippocampal formation to ovariectomy and menopause
Higaki, S., Takumi, K., Itoh, M., Watanabe, G., Taya, K., Shimizu, K., Hayashi, M., & Oishi, T. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.10.007 · Cited by 20
Signaling Pathways and Sex Differential Processes in Autism Spectrum Disorder
Enriquez, K., Gupta, A. R., & Hoffman, E. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.716673 · Cited by 20
Sex differences in Hippocampal Memory and Learning following Neonatal Brain Injury: Is There a Role for Estrogen Receptor-α?
Zafer, D., Aycan, N., Özaydın, B., Kemanli, P., Ferrazzano, P. A., Levine, J. E., & Cengiz, P. (2019) · Neuroendocrinology · doi:10.1159/000499661 · Cited by 19
Long‐term exposure of 3T3 fibroblast cells to endocrine disruptors alters sensitivity to oxidative injury
Nishimura, Y., Nakai, Y., Tanaka, A., Nagao, T., & Fukushima, N. (2014) · Cell Biology International · doi:10.1002/cbin.10269 · Cited by 18
Estrogen-Mediated Renoprotection following Cardiac Arrest and Cardiopulmonary Resuscitation Is Robust to GPR30 Gene Deletion
Hutchens, M. P., Kosaka, Y., Zhang, W. H., Fujiyoshi, T., Murphy, S. J., Alkayed, N. J., & Anderson, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099910 · Cited by 18
Interaction of Estrogen Receptor α Transactivation Domain with MTA1 Decreases in Old Mouse Brain
Thakur, M. K., & Ghosh, S. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-008-9131-1 · Cited by 18
Estrogen receptors in lipid raft signalling complexes for neuroprotection
Marín, R. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/471 · Cited by 18
Targeting Estrogen Signaling in the Radiation-induced Neurodegeneration: A Possible Role of Phytoestrogens
Mitra, S., Dash, R., Sohel, M., Chowdhury, A., Munni, Y. A., Ali, M. C., Hannan, M. A., Islam, T., & Moon, I. S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220310115004 · Cited by 19
Extranuclear signaling by estrogen: role in breast cancer progression and metastasis.
Cortez, V., Mann, M., Brann, D. W., & Vadlamudi, R. (2010) · PubMed · Cited by 18
Self-citation
Functional Adaptation in Female Rats: The Role of Estrogen Signaling
Sample, S. J., Racette, M. A., Hao, Z., Thomas, C. F., Behan, M., & Muir, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043215 · Cited by 17
Estrogen Receptor β Mediated Neuroprotective Efficacy of Cicer microphyllum Seed Extract in Global Hypoxia
Sharma, D., Biswal, S., Kumar, K., Bhardwaj, P., Barhwal, K. K., Kumar, A., Hota, S. K., & Chaurasia, O. P. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2395-5 · Cited by 17
A Recent Update on the Role of Estrogen and Progesterone in Alzheimer's Disease
Suganya, S., Ashok, B. S., & Ajith, T. A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.70025 · Cited by 19
Œstrogènes et neurogenèse : de nouvelles fonctions pour une vieille hormone. Leçons tirées du poisson zèbre
Kah, O., Pellegrini, E., Mouriec, K., Diotel, N., Anglade, I., Vaillant, C., Thieulant, M.-L., Tong, S., Brion, F., Chung, B., et al. (2009) · Journal de la Société de Biologie · doi:10.1051/jbio:2009007 · Cited by 16
Different synaptic stimulation patterns influence the local androgenic and estrogenic neurosteroid availability triggering hippocampal synaptic plasticity in the male rat
Mauro, M. D., Tozzi, A., Calabresi, P., Pettorossi, V. E., & Grassi, S. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13455 · Cited by 17
Acute inhibition of estradiol synthesis impacts vestibulo-ocular reflex adaptation and cerebellar long-term potentiation in male rats
Dieni, C. V., Ferraresi, A., Sullivan, J., Grassi, S., Pettorossi, V., & Panichi, R. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1514-z · Cited by 15
Neurocognitive, Neuroprotective, and Cardiometabolic Effects of Raloxifene: Potential for Improving Therapeutic Outcomes in Schizophrenia
Khan, M. M. (2016) · CNS Drugs · doi:10.1007/s40263-016-0343-6 · Cited by 15
Self-citation
G protein-coupled estrogen receptor 1 negatively regulates the proliferation of mouse-derived neural stem/progenitor cells via extracellular signal-regulated kinase pathway
Zhong, J., Ge, H., Zhang, C., Chen, J., Li, H., Fang, X., Tan, L., Liu, X., Jia, Z., Feng, H., et al. (2019) · Brain Research · doi:10.1016/j.brainres.2019.02.024 · Cited by 15
Estrogen, Cognitive Performance, and Functional Imaging Studies: What Are We Missing About Neuroprotection?
Marchant, I., Chabert, S., Martínez-Pinto, J., Sotomayor‐Zárate, R., Ramírez-Barrantes, R., Acevedo, L., Córdova, C., & Olivero, P. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.866122 · Cited by 16
Interaction of estrogen receptor‐α ligand binding domain with nuclear proteins of aging mouse brain
Ghosh, S., & Thakur, M. K. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22068 · Cited by 14
The unliganded long isoform of estrogen receptor beta stimulates brain ryanodine receptor single channel activity alongside with cytosolic Ca2+
Rybalchenko, V., Grillo, M. A., Gastinger, M. J., Rybalchenko, N., Payne, A. J., & Koulen, P. (2009) · Journal of Receptors and Signal Transduction · doi:10.3109/10799890903295168 · Cited by 14
Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System
Han, B., Tokay, T., Zhang, G., Sun, P., & Hou, S. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7371010 · Cited by 13
Electrochemical characterization of 17β‐estradiol with fast‐scan cyclic voltammetry
Weese‐Myers, M. E., & Ross, A. E. (2023) · Electroanalysis · doi:10.1002/elan.202200560 · Cited by 12
Expression profile of the aromatase enzyme in the Xenopus brain and localization of estradiol and estrogen receptors in each tissue
Iwabuchi, J., Koshimizu, K., & Nakagawa, T. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.09.024 · Cited by 12
Increased expression of PELP1 in human sperm is correlated with decreased semen quality
Skibińska, I., Andrusiewicz, M., Soin, M., Jendraszak, M., Urbaniak, P., Jędrzejczak, P., & Kotwicka, M. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_11_18 · Cited by 12
20-Hydroxyecdysone activates the protective arm of the renin angiotensin system via Mas receptor
Lafont, R., Raynal, S., Serova, M., Didry-Barca, B., Guibout, L., Latil, M., Dilda, P. J., Dioh, W., & Veillet, S. (2020) · doi:10.1101/2020.04.08.032607 · Cited by 11
AIB1 shows variation in interaction with ERβTAD and expression as a function of age in mouse brain
Paramanik, V., & Thakur, M. K. (2011) · Biogerontology · doi:10.1007/s10522-011-9330-y · Cited by 11
Expression of estrogen receptor α in the mouse cerebral cortex
Dietrich, A. K., Humphreys, G. I., & Nardulli, A. M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.013 · Cited by 10
Striatin family proteins: The neglected scaffolds
Tanti, G. K., Pandey, P., Shreya, S., & Jain, B. P. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119430 · Cited by 10
PELP1 promotes glioblastoma progression by enhancing Wnt/β-catenin signaling
Sareddy, G. R., Pratap, U. P., Viswanadhapalli, S., Venkata, P. P., Nair, B. C., Krishnan, S. R., Zheng, S., Gilbert, A., Brenner, A. J., Brann, D. W., et al. (2019) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdz042 · Cited by 10
Self-citation
Modulation of estrogen receptors during development inhibits neurogenesis of precursors to GnRH-1 neurones: In vitro studies with explants of ovine olfactory placode
Agça, E., Batailler, M., Tillet, Y., Chemineau, P., & Duittoz, A. H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.026 · Cited by 13
Rapid Effects of Oestrogen on Intracellular Ca2+ in the Uterine Junctional Myometrium of Patients With and Without Adenomyosis in Different Phases of the Menstrual Cycle
Wang, S., Duan, H., & Li, B. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00218-2 · Cited by 9
Hormones and Cerebellar Development
Koibuchi, N., & Ikeda, Y. (2012) · Springer eBooks · doi:10.1007/978-94-007-1333-8_16 · Cited by 8
Cooperative effect of E2 and FGF2 on lactotroph proliferation triggered by signaling initiated at the plasma membrane
Sosa, L. D. V., Gutiérrez, S., Petiti, J. P., Vaca, A., Paul, A. L. D., & Torres, A. I. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00027.2013 · Cited by 8
Can distinctly different rapid estrogen actions share a common mechanistic step?
Kow, L., & Pfaff, D. W. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.02.008 · Cited by 8
The Measurement of Estrogens
Holder, G., Makin, H. L. J., & Bradlow, H. L. (2010) · Springer eBooks · doi:10.1023/b135931_8 · Cited by 8
Calmodulin effects on steroids‐regulated plasma membrane calcium pump activity
Żylińska, L., Kowalska, I., & Ferenc, B. (2009) · Cell Biochemistry and Function · doi:10.1002/cbf.1543 · Cited by 8
Endocrine disrupting effects on morphological synaptic plasticity
Zsarnovszky, A., Alymbaeva, D., Jocsak, G., Szabo, C., Mária Schilling-Tóth, B., & Sandor Kiss, D. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101157 · Cited by 7
Effects of estradiol on high-voltage-activated Ca2+channels in cultured rat cortical neurons
Wang, Q., Ye, Q., Lu, R., Cao, J., Wang, J., Ding, H., Gao, R., & Xiao, H. (2013) · Endocrine Research · doi:10.3109/07435800.2013.799485 · Cited by 7
Activation of Membrane Estrogen Receptors Attenuates NOP-Mediated Tactile Antihypersensitivity in a Rodent Model of Neuropathic Pain
Wright, D. M., Small, K. M., Nag, S., & Mokha, S. S. (2019) · Brain Sciences · doi:10.3390/brainsci9060147 · Cited by 6
Membrane receptors mediate the rapid facilitation of short‐term memory by estradiol in the dorsal hippocampus of female mice
Kuun, T., Brar, R., Klemens, M. N., MacLusky, N. J., & Choleris, E. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13282 · Cited by 5
Chemical Inhibition of NRF2 Transcriptional Activity Influences Colon Function and Oestrogen Receptor Expression in Mice at Different Ages
Piechota-Polańczyk, A., Mariwani, Z., Fichna, J., Polańczyk, A., & Józkowicz, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413647 · Cited by 5
Effects of Estrogen on Neuronal KCNQ2/3 Channels Expressed in PC-12 Cells
Dai, X., Liu, Y., Wang, C., Luo, Y., Li, X., & Shen, Z. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00357 · Cited by 5
Lithium: a potential estrogen signaling modulator
Valdés, J. J., & Weeks, O. I. (2009) · Journal of Applied Biomedicine · doi:10.32725/jab.2009.020 · Cited by 4
Effects of estrogen on social recognition and oxytocin regulating synaptic plasticity
Gao, T., Ying, Z., Yang, Y., & Xu, X. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114843 · Cited by 4
Disruptions in reproductive health, sex hormonal profiles, and hypothalamic hormone receptors content in females of the C58/J mouse model of autism
Barón-Mendoza, I., Martínez‐Marcial, M., García‐Juárez, M., Mejía-Hernández, M., Cortés-Sánchez, Y., Zamora-Sánchez, C. J., Rebollar, J. O. G., Chavira‐Ramírez, R., Ordaz‐Rosado, D., Camacho‐Arroyo, I., et al. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105593 · Cited by 3
An Endocrine-Disrupting Chemical, Bisphenol A Diglycidyl Ether (BADGE), Accelerates Neuritogenesis and Outgrowth of Cortical Neurons via the G-Protein-Coupled Estrogen Receptor
Miyazaki, I., Nishiyama, C., Nagoshi, T., Miyako, A., Ono, S., Misawa, I., Isse, A., Tomimoto, K., Masai, K., Zensho, K., et al. (2025) · NeuroSci · doi:10.3390/neurosci6020053 · Cited by 2
Histologic Distribution, Fragment Cloning, and Sequence Analysis of G Protein Couple Receptor 30 in Rat Submaxillary Gland
Chen, L., Mei, X., Gao, C., Zhang, G., & Sun, X. (2011) · The Anatomical Record · doi:10.1002/ar.21349 · Cited by 2
Long-term effects of post-ischaemic oestrogen on brain injury in a rat transient forebrain ischaemia model
Nagasaki, G., Horiguchi, T., Nishikawa, T., Masaki, Y., & Tobe, Y. (2013) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12172 · Cited by 2
Membrane-Initiated Estrogen Actions on Ion Channels and the Induction of Lordosis, the Rodent Female Sexual Behavior
Kow, L. (2009) · The Chinese Journal of Physiology · doi:10.4077/cjp.2009.amh044 · Cited by 2
The STRIPAK complex and its role in fruiting-body development of the filamentous fungus Sordaria macrospora
Frey, S. (2015) · doi:10.53846/goediss-5284 · Cited by 2
Synbiotics as Modulators of Developing Brain for Reproductive Development Via Estrogen Receptors in Male Coturnix Coturnix Japonica
Khan, A. G., Sikdar, M., Kango, N., & Srivastava, R. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04528-2 · Cited by 1
Developmental Profile and Subcellular Localization of The Non-genomic Membranous Estrogen Receptor GPR30 in The Hippocampus of Postnatal Female Rats*
Zhao, C., Deng, Q., Zhang, D., Cai, W., & Zhang, J. (2009) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2008.00207 · Cited by 1
Membrane-initiated signaling of estrogen related to neuroprotection. “Social networks” are required
Marín, R., Marrero‐Alonso, J., Fernández, C., Cury, D., & Díaz, M. L. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.109 · Cited by 1
Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus
Thakkar, R., Wang, R., Sareddy, G. R., Vadlamudi, R. K., & Brann, D. W. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190645908.003.0024 · Cited by 1
Self-citation
Molecular studies of dyslexia : regulation and function of DYX1C1
Tammimies, K. (2011) · Figshare · Cited by 1
Estrogen and Lithium: Facilitating Factors Involved in Brain Cell Signaling Pathways
Valdes, J. J. (2009) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fi09120801 · Cited by 1
Untersuchung der Fruchtkörperentwicklung bei dem Hyphenpilz Sordaria macrospora
Bernhards, Y. (2010) · doi:10.53846/goediss-407 · Cited by 1
The Effects of 17- Beta Estradiol on G-Protein Inwardly Rectifying Potassium Channels (GIRKs) in Breast Cancer
Hance, M. W. (2009)
HIV-1 AND COCAINE: MOTIVATION AND SYNAPTIC FUNCTION
Bertrand, S. J. (2015) · Scholar Commons (University of South Carolina)
The role of estrogen regulation in brain development and neurodegeneration
Csöregh, L. (2009) · Figshare
Efeito da proteção desencadeada pelo estrógeno na linhagem C6 de glioma de rato.
Franco, L. A. M. (2011) · doi:10.11606/d.42.2011.tde-16082011-093651
Depressione e climaterio
Graziottin, A., & Serafini, A. (2009) · Quaderni Italiani di Psichiatria · doi:10.1016/j.quip.2008.11.005
The role of gonadal hormones in mesencephalic dopaminergic systems
Johnson, M. L. (2008) · DukeSpace (Duke University)
PARTICIPAÇÃO DO RECEPTOR GPER-1 NA NEUROPROTEÇÃO MEDIADA POR ESTRÓGENO EM MODELO DE ISQUEMIA POR PRIVAÇÃO DE GLICOSE/OXIGÊNIO EM CÉLULAS CORTICAIS CEREBRAIS
Scavone, C. (2014)
Bioscience Frontiers in Neuromedical Interventions Following Brain Injury
Ashley, M. J., Weintraub, A. H., & Ripley, D. L. (2010) · CRC Press eBooks · doi:10.1201/9781439849828-c12
Selective Fluidization of Synaptosomal Plasma Membrane Vesicles by 17β-Estradiol
Lee, S. A., Park, Y., Jang, I. H., & Kang, J. S. (2017) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2017.23.1.17
Assessing the Anticancer Potential of Natural Health Products (Lemongrass, Hibiscus, and Eleuthero Ginseng) Against Breast Cancer Models
Stanesic, M. (2017) · Scholarship at UWindsor (University of Windsor)
An interview with Professor Virendra B. Mahesh
Nowak, R. A. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy239
Cerebral Ischemia and Estrogen Role: A Review about Classification, Experimental Models, Mechanism of Neural Cell Death after Ischemia and Estrogen Role in Ischemia
Mohamed, S. K., Ahmed, A. A. E., Morsy, E. M. E., & Nofal, S. (2019) · Journal of Advanced Pharmacy Research · doi:10.21608/aprh.2019.7791.1077
Hormonal Fluctuations Related to Depressive Symptoms in Menopause
Bălan, A., Dvornic, P., Nisioi, C., Martinescu, C. C., Panait, D. E., & Moga, M. (2020) · Bulletin of the Transilvania University of Brasov Series VI Medical Sciences · doi:10.31926/but.ms.2020.62.13.2.1
The Role of Membrane-Bound Receptors in the Rapid Estrogenic Enhancements of Learning and Memory Within the Hippocampus
Kuun, T. (2021) · The Atrium (University of Guelph)
Hormones and Cerebellar Development
Koibuchi, N., & Ikeda, Y. (2021) · Springer eBooks · doi:10.1007/978-3-030-23810-0_16
Hormones and Cerebellar Development
Koibuchi, N., & Ikeda, Y. (2020) · Springer eBooks · doi:10.1007/978-3-319-97911-3_16-2
Faculty Opinions recommendation of Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivo.
Crystal, G. J. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.2785956.2453054
Participación del 17β-estradiol y el receptor 5-HT1A en las alteraciones conductuales en un modelo animal de depresión
Limón‐Morales, O. (2011) · doi:10.24275/uami.vh53wv90n
Sexual dimorphisms in phrenic long-term facilitation following severe acute intermittent hypoxia
Dougherty, B. J., & Grittner, J. M. L. (2026) · Journal of Neurophysiology · doi:10.1152/jn.00446.2025
Effets de l’exposition aux phtalates sur les comportements de reproduction de la souris femelle
Adam, N. (2022) · theses.fr (ABES) · doi:10.70675/f8535eb9z782dz40b8zb1d0z583132d3fd1b

Authors: Raz, L., Khan, M. M., Mahesh, V. B., Vadlamudi, R. K., & Brann, D. W.
Affiliations: Augusta University (US)
The University of Texas at San Antonio Health Science Center (US)
ORCID: Raz, Limor
Khan, Mohammad M.
Vadlamudi, Ratna K.
Brann, Darrell W.
Venue: Neurosignals
Publisher: S. Karger AG
Published: 2008
Volume: 16
Issue: 2-3
Pages: 140-153
ISSN: 1424-862X (ISSN-L)
1424-8638
DOI: 10.1159/000111559
OpenAlex: W1985323921
Cited by: 201
References: 128
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 3 · 2015: 12 · 2014: 15 · 2013: 17 · 2012: 17
FWCI: 2.75
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Neurosignals (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 95681, R01CA095681)
National Institute of Neurological Disorders and Stroke (NS050730, R01NS050730)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: membrane estrogen receptor, GPR30, kinase signaling, Src kinase, phosphatidylinositol 3-kinase, striatin, p130Cas, calcium signaling, ion channel signaling, synaptic plasticity, cognition, neuroprotection, plasma membrane
MeSH terms: Animals, Brain, Estrogens, Humans, Neuronal Plasticity, Receptors, Estrogen, Time Factors, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rapid Estrogen Signaling in the Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks