Expression of estrogen receptor α in the mouse cerebral cortex
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Although estrogen receptor alpha (ERα) and 17β-estradiol play critical roles in protecting the cerebral cortex from ischemia-induced damage, there has been some controversy about the expression of ERα in this region of the brain. We have examined ERα mRNA and protein levels in the cerebral cortices of female mice at postnatal days 5 and 17 and at 4, 13, and 18 months of age. We found that although ERα transcript levels declined from postnatal day 5 through 18 months of age, ERα protein levels remained stable. Importantly, expression of the E2-regulated progesterone receptor gene was sustained in younger and in older females suggesting that age-related changes in estrogen responsiveness in the cerebral cortex are not due to the absence of ERα protein.
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In mice, while ERalpha mRNA transcript levels decrease through life, protein expression remains stable.
“These studies mirror a study in mice that found that while ERalpha mRNA transcript levels decrease through life, protein expression remains stable (Dietrich et al., 2015).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Dietrich et al., 2015
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- Authors
- Dietrich, A. K., Humphreys, G. I., & Nardulli, A. M.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Nardulli, Ann M.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 406
- Pages
- 19-26
- ISSN
- 0303-7207 (ISSN-L)
- PMC
- PMC4773199
- OpenAlex
- W1998175914
- Cited by
- 10
- References
- 72
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2017: 1 · 2016: 2
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01DK 053884)
- NIEHS (T32 ES007326)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- estrogen receptor alpha, cerebral cortex, estrogen response, progesterone receptor, estradiol, age-related gene expression, postnatal development, female mice
- MeSH terms
- Animals, Cerebral Cortex, Estradiol, Female, Longevity, Mice, Inbred C57BL, Receptors, Progesterone, RNA, Messenger, Reproducibility of Results, Gene Expression Regulation, Developmental, Estrogen Receptor alpha
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