Rapid Estrogen Signaling in the Brain

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302

Estrogen Actions in the Central Nervous System

McEwen, B. S., & Alves, S. E. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0365 · Cited by 1,504

Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells

Thomas, P., Pang, Y., Filardo, E. J., & Dong, J. (2004) · Endocrinology · doi:10.1210/en.2004-1064 · Cited by 1,410

Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF

Filardo, E. J., Quinn, J. A., Bland, K. I., & Frackelton, A. R. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.10.0532 · Cited by 1,387

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

Hall, J. M., Couse, J. F., & Korach, K. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100029200 · Cited by 1,202

Skeletal Effects of Estrogen*

Turner, R. T., Riggs, B. L., & Spelsberg, T. C. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-275 · Cited by 758

Integration of the extranuclear and nuclear actions of estrogen

Levin, E. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0390 · Cited by 708

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

Brann, D. W., Dhandapani, K. M., Wakade, C. G., Mahesh, V. B., & Khan, M. M. (2007) · Steroids · doi:10.1016/j.steroids.2007.02.003 · Cited by 677

A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.

Sakai, R., Iwamatsu, A., Hirano, N., Ogawa, S., Tanaka, T., Mano, H., Yazaki, Y., & Hirai, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06684.x · Cited by 648

Estrogen Actions in the Central Nervous System

McEwen, B. S. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.279 · Cited by 640

Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor

Mermelstein, P. G., Becker, J., & Surmeier, D. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00595.1996 · Cited by 627

Identification of a Gene (GPR30) with Homology to the G-Protein-Coupled Receptor Superfamily Associated with Estrogen Receptor Expression in Breast Cancer

Carmeci, C., Thompson, D. A., Ring, H. Z., Francke, U., & Weigel, R. J. (1997) · Genomics · doi:10.1006/geno.1997.4972 · Cited by 590

Estrogen and cognitive functioning in women

Sherwin, B. B. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0016 · Cited by 560

ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury

Toran‐Allerand, C. D., Guan, X., MacLusky, N. J., Horváth, T. L., Diano, S., Singh, M., Connolly, E. S., Nethrapalli, I. S., & Tinnikov, A. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08391.2002 · Cited by 547

Nature of Functional Estrogen Receptors at the Plasma Membrane

Pedram, A., Razandi, M., & Levin, E. R. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0525 · Cited by 523

Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system

Brailoiu, E., Dun, S. L., Brailoiu, G. C., Mizuo, K., Sklar, L. A., Oprea, T. I., Prossnitz, E. R., & Dun, N. J. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0017 · Cited by 501

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

Watters, J. J., Campbell, J. S., Cunningham, M. J., Krebs, E. G., & Dorsa, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.9.5489 · Cited by 490

Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways

Singh, M., Sétáló, G., Guan, X., Warren, M., & Toran‐Allerand, C. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01179.1999 · Cited by 465

Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons

Wong, M., & Moss, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-08-03217.1992 · Cited by 462

Rapid Signaling of Estrogen in Hypothalamic Neurons Involves a Novel G-Protein-Coupled Estrogen Receptor that Activates Protein Kinase C

Qiu, J., Bosch, M. A., Tobias, S. C., Grandy, D. K., Scanlan, T. S., Rønnekleiv, O. K., & Kelly, M. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09529.2003 · Cited by 460

A Conserved Mechanism for Steroid Receptor Translocation to the Plasma Membrane

Pedram, A., Razandi, M., Sainson, R. C. A., Kim, J. K., Hughes, C. C. W., & Levin, E. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611877200 · Cited by 449

Palmitoylation-dependent Estrogen Receptor α Membrane Localization: Regulation by 17β-Estradiol

Acconcia, F., Ascenzi, P., Bocedi, A., Spisni, E., Tomasi, V., Trentalance, A., Visca, P., & Marino, M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0547 · Cited by 440

Genomic Targets of Nuclear Estrogen Receptors

O’Lone, R. B., Frith, M. C., Karlsson, E. K., & Hansen, U. M. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0044 · Cited by 439

Induction of p130 cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

Vuori, K., Hirai, H., Aizawa, S., & Ruoslahti, E. I. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2606 · Cited by 421

ERs Associate with and Regulate the Production of Caveolin: Implications for Signaling and Cellular Actions

Razandi, M., Oh, P., Pedram, A., Schnitzer, J. E., & Levin, E. R. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.1.0757 · Cited by 402

GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release

Filardo, E. J., & Thomas, P. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.08.005 · Cited by 388

Ultrastructural localization of estrogen receptor β immunoreactivity in the rat hippocampal formation

Milner, T. A., Ayoola, K. A., Drake, C., Herrick, S. P., Tabori, N., Mcewen, B. S., Warrier, S., & Alves, S. E. (2005) · The Journal of comparative neurology · doi:10.1002/cne.20724 · Cited by 370

G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane

Funakoshi, T., Yanai, A., Shinoda, K., Kawano, M. M., & Mizukami, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.191 · Cited by 352

17β-Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade

Gu, Q., & Moss, R. L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03620.1996 · Cited by 344

Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor α

Lu, Q. R., Pallas, D. C., Surks, H. K., Baur, W. E., Mendelsohn, M. E., & Karas, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407492101 · Cited by 266

Mechanism of the Rapid Effect of 17β-Estradiol on Medial Amygdala Neurons

Nabekura, J., Oomura, Y., Minami, T., Mizuno, Y., & Fukuda, A. (1986) · Science · doi:10.1126/science.3726531 · Cited by 262

Emerging diversities in the mechanism of action of steroid hormones

Brann, D. W., Hendry, L. B., & Mahesh, V. B. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)00160-n · Cited by 261

Estrogen-Induced Activation of the Mitogen-Activated Protein Kinase Cascade in the Cerebral Cortex of Estrogen Receptor-α Knock-Out Mice

Singh, M., Sétáló, G., Guan, X., Frail, D. E., & Toran‐Allerand, C. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01694.2000 · Cited by 250

17β-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: A potential initiation mechanism for estrogen-induced neuroprotection

Wu, T.-W., Wang, J.-M., Chen, S.-H., & Brinton, R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.027 · Cited by 249

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

Etienne‐Manneville, S., Adamson, P., Greenwood, J., Strosberg, A. D., Cazaubon, S. M., & Couraud, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5755 · Cited by 248

Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action

Harrington, W. R., Kim, S. H., Funk, C. C., Madak‐Erdogan, Z., Schiff, R., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0186 · Cited by 246

Skeletal effects of estrogen

Turner, R. T. (1994) · Endocrine Reviews · doi:10.1210/er.15.3.275 · Cited by 242

Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles

Vasudevan, N., & Pfaff, D. W. (2007) · Endocrine Reviews · doi:10.1210/er.2005-0021 · Cited by 231

Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways

Kelly, M. J. (1999) · Steroids · doi:10.1016/s0039-128x(98)00095-6 · Cited by 227

Rapid modulation of long‐term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons

Mukai, H., Tsurugizawa, T., Murakami, G., Kominami, S., Ishii, H., Ogiue‐Ikeda, M., Takata, N., Tanabe, N., Furukawa, A., Hojo, Y., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04264.x · Cited by 223

Steering estrogen signals from the plasma membrane to the nucleus: Two sides of the coin

Manavathi, B., & Kumar, R. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20551 · Cited by 222

Protective Effects of Estrogen and Selective Estrogen Receptor Modulators in the Brain1

Dhandapani, K. M., & Brann, D. W. (2002) · Biology of Reproduction · doi:10.1095/biolreprod.102.003848 · Cited by 220

Estrogen Receptor β Mediates Rapid Estrogen Actions on Gonadotropin-Releasing Hormone NeuronsIn Vivo

Ábrahám, I. M., Han, S., Todman, M. G., Korach, K. S., & Herbison, A. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05771.2003 · Cited by 215

Estrogen-containing hormone therapy and Alzheimer’s disease risk: Understanding discrepant inferences from observational and experimental research

Henderson, V. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.017 · Cited by 215

Estrogen Receptor Protein Interaction with Phosphatidylinositol 3-Kinase Leads to Activation of Phosphorylated Akt and Extracellular Signal-Regulated Kinase 1/2 in the Same Population of Cortical Neurons: A Unified Mechanism of Estrogen Action

Mannella, P., & Brinton, R. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-06.2006 · Cited by 213

Estrogen Receptor-Mediated Rapid Signaling

Moriarty, K., Kim, K. H., & Bender, J. R. (2006) · Endocrinology · doi:10.1210/en.2006-0729 · Cited by 205

Direct and Indirect Regulation of Gonadotropin-Releasing Hormone Neurons by Estradiol1

Petersen, S. L., Ottem, E. N., & Carpenter, C. D. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.019745 · Cited by 201

Nonclassical estrogen receptor α signaling mediates negative feedback in the female mouse reproductive axis

Glidewell-Kenney, C., Hurley, L., Pfaff, L. E., Weiss, J., Levine, J. E., & Jameson, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611514104 · Cited by 200

Differential Effects of Estradiol and Estradiol-BSA Conjugates

Stevis, P. E., Deecher, D. C., Suhadolnik, L., Mallis, L. M., & Frail, D. E. (1999) · Endocrinology · doi:10.1210/endo.140.11.7247 · Cited by 197

Critical in Vivo Roles for Classical Estrogen Receptors in Rapid Estrogen Actions on Intracellular Signaling in Mouse Brain

Ábrahám, I. M., Todman, M. G., Korach, K. S., & Herbison, A. E. (2004) · Endocrinology · doi:10.1210/en.2003-1676 · Cited by 197

Molecular Cloning and Characterization of PELP1, a Novel Human Coregulator of Estrogen Receptor α

Vadlamudi, R. K., Wang, R., Mazumdar, A., Şahin, A. A., Kumar, R., Kim, Y.-S., & Shin, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103783200 · Cited by 193

The effects of microelectrophoretically applied estrogen, cortisol and acetylcholine on medial preoptic-septal unit activity throughout the estrous cycle of the female rat

Kelly, M. J., Moss, R. L., & Dudley, C. A. (1977) · Experimental Brain Research · doi:10.1007/bf00237858 · Cited by 185

S-palmitoylation modulates human estrogen receptor-α functions

Acconcia, F., Ascenzi, P., Fabozzi, G., Visca, P., & Marino, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.129 · Cited by 180

Receptor Mechanisms Mediating Non-Genomic Actions of Sex Steroids

Boonyaratanakornkit, V., & Edwards, D. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-973427 · Cited by 178

The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions

Kow, L., & Pfaff, D. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404889101 · Cited by 171

Differential sensitivity of preoptic-septal neurons to microelectrophoressed estrogen during the estrous cycle

Kelly, M. J., Moss, R. L., & Dudley, C. A. (1976) · Brain Research · doi:10.1016/0006-8993(76)91017-9 · Cited by 170

Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line

Vasudevan, N., Kow, L., & Pfaff, D. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221449798 · Cited by 159

Single unit recording in hypothalamus and preoptic area of estrogen-treated and untreated ovariectomized female rats

Bueno, J., & Pfaff, D. W. (1976) · Brain Research · doi:10.1016/0006-8993(76)90988-4 · Cited by 157

Estradiol Stimulates Progesterone Synthesis in Hypothalamic Astrocyte Cultures

Micevych, P. E., Chaban, V. V., Ogi, J., Dewing, P., Lu, J. K. H., & Sinchak, K. (2006) · Endocrinology · doi:10.1210/en.2006-0774 · Cited by 138

Nongenomic effects of oestrogen: embryonic mouse midbrain neurones respond with a rapid release of calcium from intracellular stores

Beyer, C., & Raab, H. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00045.x · Cited by 138

The specificity of the response of preoptic-septal area neurons to estrogen: 17?-estradiol versus 17?-estradiol and the response of extrahypothalamic neurons

Kelly, M. J., Moss, R. L., Dudley, C. A., & Fawcett, C. P. (1977) · Experimental Brain Research · doi:10.1007/bf00237857 · Cited by 137

Estrogen Modulation of G‐Protein‐Coupled Receptor Activation of Potassium Channels in the Central Nervous System

Kelly, M. J., Qiu, J., & Rønnekleiv, O. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.001 · Cited by 135

MAPK Signaling Is Critical to Estradiol Protection of CA1 Neurons in Global Ischemia

Jover‐Mengual, T., Zukin, R. S., & Etgen, A. M. (2006) · Endocrinology · doi:10.1210/en.2006-1137 · Cited by 131

17β-estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: A potential initiation mechanism for estrogen neurotrophism

Zhao, L.-Q., Chen, S.-H., Wang, M. J., & Brinton, R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.054 · Cited by 129

A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons

Castets, F., Bartoli, M., Barnier, J. V., Baillat, G., Salin, P., Moqrich, A., Bourgeois, J. P., Denizot, F., Rougon, G., Calothy, G., et al. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.1051 · Cited by 129

p130Cas interacts with estrogen receptor α and modulates non-genomic estrogen signaling in breast cancer cells

Cabodi, S., Moro, L., Baj, G., Smeriglio, M., Stefano, P. D., Gippone, S., Surico, N., Silengo, L., Turco, E., Tarone, G., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.01025 · Cited by 128

Zinedin, SG2NA, and Striatin Are Calmodulin-binding, WD Repeat Proteins Principally Expressed in the Brain

Castets, F., Rakitina, T. V., Gaillard, S., Moqrich, A., Mattéi, M., & Monneron, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909782199 · Cited by 127

Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons

Honda, K., Shimohama, S., Sawada, H., Kihara, T., Nakamizo, T., Shibasaki, H., & Akaike, A. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1098 · Cited by 126

Putative membrane-bound estrogen receptors possibly stimulate mitogen-activated protein kinase in the rat hippocampus

Kuroki, Y., Fukushima, K., Kanda, Y., Mizuno, K., & Watanabe, Y. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00425-8 · Cited by 126

Estrogen induces a rapid secretion of amyloid β precursor protein via the mitogen‐activated protein kinase pathway

Manthey, D., Heck, S., Engert, S., & Behl, C. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02346.x · Cited by 122

Comparative distribution of mRNA encoding the growth hormone secretagogue‐receptor (GHS‐R) in Microcebus murinus (Primate, Lemurian) and rat forebrain and pituitary

Mitchell, V. A., Bouret, S. G., Beauvillain, J., Schilling, A., Perret, M., Kordon, C., & Epelbaum, J. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010115)429:3 · Cited by 119

Changes in firing rates of single preoptic and hypothalamic units following an intravenous administration of estrogen in the castrated female rat

Yagi, K. (1973) · Brain Research · doi:10.1016/0006-8993(73)90219-9 · Cited by 116

Sex Differences in Hippocampal Estradiol-Induced N-Methyl-D-Aspartic Acid Binding and Ultrastructural Localization of Estrogen Receptor-Alpha

Romeo, R. D., McCarthy, J. B., Wang, A. C., Milner, T. A., & McEwen, B. S. (2005) · Neuroendocrinology · doi:10.1159/000089557 · Cited by 115

Requirements for estrogen receptor α membrane localization and function

Evinger, A. J., & Levin, E. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.015 · Cited by 108

Estrogen as Neuroprotectant of Nigrostriatal Dopaminergic System: Laboratory and Clinical Studies

Dluzen, D. E., & Horstink, M. W. I. M. (2003) · Endocrine · doi:10.1385/endo:21:1:67 · Cited by 106

Caveolin-1 Mutations in Human Breast Cancer

Li, T., Sotgia, F., Vuolo, M. A., Li, M., Yang, W., Pestell, R. G., Sparano, J. A., & Lisanti, M. P. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051089 · Cited by 105

The striatin family: A new signaling platform in dendritic spines

Benoist, M., Gaillard, S., & Castets, F. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2005.12.006 · Cited by 104

Diversity of ovarian steroid signaling in the hypothalamus

Rønnekleiv, O. K., & Kelly, M. J. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.05.001 · Cited by 102

Neuroprotection by estrogen via extracellular signal‐regulated kinase against quinolinic acid‐induced cell death in the rat hippocampus

Kuroki, Y., Fukushima, K., Kanda, Y., Mizuno, K., & Watanabe, Y. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01409.x · Cited by 98

Estrogen activates rapid signaling in the brain: Role of estrogen receptor α and estrogen receptor β in neurons and glia

Mhyre, A. J., & Dorsa, D. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.019 · Cited by 97

Regulation of Cyclic Adenosine 3′,5′-Monophosphate Signaling and Pulsatile Neurosecretion by Gi-coupled Plasma Membrane Estrogen Receptors in Immortalized Gonadotropin-Releasing Hormone Neurons

Navarro, C. E., Saeed, S. A., Murdock, C. M., Martínez‐Fuentes, A. J., Arora, K. K., Krsmanović, L. Z., & Catt, K. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0040 · Cited by 93

Estradiol enhances Akt activation in cortical explant cultures following neuronal injury

Wilson, M. E., Liu, Y., & Wise, P. M. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00181-x · Cited by 89

Cortical inputs to m2‐immunoreactive striatal interneurons in rat and monkey

Thomas, T. M., Smith, Y., Levey, A., & Hersch, S. (2000) · Synapse · doi:10.1002/1098-2396(20000915)37:4 · Cited by 84

Binding of estrogen receptor with estrogen conjugated to bovine serum albumin (BSA)

Taguchi, Y., Koslowski, M., & Bodenner, D. (2004) · Nuclear Receptor · doi:10.1186/1478-1336-2-5 · Cited by 82

UNIT ACTIVITY IN THE HYPOTHALAMUS, SEPTUM AND PREOPTIC AREA OF THE RAT: CHARACTERISTICS OF SPONTANEOUS ACTIVITY AND THE EFFECT OF OESTROGEN

LINCOLN, D. W. (1967) · Journal of Endocrinology · doi:10.1677/joe.0.0370177 · Cited by 82

Plasma membrane oestrogen receptor mediates neuroprotection against β‐amyloid toxicity through activation of Raf‐1/MEK/ERK cascade in septal‐derived cholinergic SN56 cells

Guerra, B., Díaz, M. L., Alonso, R., & Marín, R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02695.x · Cited by 82

Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR

Vadlamudi, R. K., & Kumar, R. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05004 · Cited by 79

Estrogen receptor-α mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons

Chaban, V. V., & Micevych, P. E. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20524 · Cited by 78

Photoreceptor phagocytosis selectively activates PPAR? expression in retinal pigment epithelial cells

Ershov, A. V., & Bazan, N. G. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000501)60:3 · Cited by 74

Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-?b, and MAP kinases

Chung, K. C., Park, J. H., Kim, C. H., Lee, H. W., Sato, N., Uchiyama, Y., & Ahn, Y. S. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000101)59:1 · Cited by 74

Effects of Estrogen on the Electrical Activity of Identified and Unidentified Hypothalamic Units

DUFY, B., Partouche, C., Poulain, D., Dufy-Barbe, L., & Vincent, J. D. (2008) · Neuroendocrinology · doi:10.1159/000122610 · Cited by 68

Distinctive Actions of Membrane-Targeted Versus Nuclear Localized Estrogen Receptors in Breast Cancer Cells

Rai, D., Frolova, A. I., Frasor, J. M., Carpenter, A. E., & Katzenellenbogen, B. S. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0468 · Cited by 66

Ack1 Mediates Cdc42-dependent Cell Migration and Signaling to p130Cas

Modzelewska, K., Newman, L. P., Desai, R. C., & Keely, P. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604342200 · Cited by 65

Interaction of Calmodulin with Striatin, a WD-repeat Protein Present in Neuronal Dendritic Spines

Bartoli, M., Monneron, A., & Ladant, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22248 · Cited by 63

17-β Estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain

Bryant, D. N., Bosch, M. A., Rønnekleiv, O. K., & Dorsa, D. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.024 · Cited by 62

p130CASIs Required for Netrin Signaling and Commissural Axon Guidance

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Moqrich, A., Mattei, M. G., Bartoli, M., Rakitina, T., Baillat, G., Monneron, A., & Castets, F. (1998) · Genomics · doi:10.1006/geno.1998.5342 · Cited by 32

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Untitled work

Salin (1998) · doi:10.1002/(sici)1096-9861(19980720)397:1

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