The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?
Abstract
Background: Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer’s disease (AD), their effect on cognitive status has been only rarely assessed. Methods: The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up. Results: Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms. Conclusion: These observations suggest that ATD may reduce cognitive decline in depressed older AD patients.
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Mossello et al. suggested that cognitive protection was possibly via a reduction in depressive symptoms after taking antidepressants.
“They further suggested that cognitive protection was possibly via a reduction in depressive symptoms after taking antidepressants”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [54]
Mossello et al. mentioned that antidepressant treatment would protect cognitive function in depressed older patients with AD.
“Mossello et al. mentioned that antidepressant treatment would protect cognitive function in depressed older patients with AD [54].”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [54]
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Lyketsos, C. G., DelCampo, L., Steinberg, M., Miles, Q., Steele, C. D., Munro, C., Baker, A. S., Sheppard, J.-M. E., Frangakis, C., Brandt, J., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.7.737 · Cited by 398
Guidelines for the treatment of Alzheimer’s disease from the Italian Association of Psychogeriatrics
Caltagirone, C., Bianchetti, A., Luca, M. D., Mecocci, P., Padovani, A., Pirfo, E., Scapicchio, P., Senin, U., Trabucchi, M., & Musicco, M. (2005) · Drugs & Aging · doi:10.2165/00002512-200522001-00002 · Cited by 55 · cited 1×
“Adding to these uncertainties, the clinical effects of pharmacologic treatment of depression associated with AD are controversial. Although a consensus exists that a treatment is usually indicated and that selective serotonin reuptake inhibitors (SSRI) are the first-line agents in this setting [”
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Cited by
Sorted by citations
Orgeta, V., Tabet, N., Nilforooshan, R., & Howard, R. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161247 · Cited by 203
Then, C.-K., Chi, N.-F., Chung, K.-H., Kuo, L., Liu, K.-H., Hu, C.-J., Shen, S.-C., & Lin, Y.-K. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175187 · Cited by 35
Metadata
- Authors
- Mossello, E., Boncinelli, M., Caleri, V., Cavallini, M. C., Palermo, E., Di Bari, M., Tilli, S., Sarcone, E., Simoni, D., Biagini, C. A., Masotti, G., & Marchionni, N.
- Affiliations
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2008
- Volume
- 25
- Issue
- 4
- Pages
- 372-379
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2047425535
- Cited by
- 61
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 6
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- antidepressants, Alzheimer's disease, cognitive decline, depressive symptoms, geriatric depression, cholinesterase inhibitors, treatment continuity
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Antidepressive Agents, Cognition, Cognition Disorders, Depression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, Severity of Illness Index, Treatment Outcome
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