A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia

Nyth, A. L.; Gottfries, C. G.; Lyby, K.; Smedegaard‐Andersen, L.; Gylding‐Sabroe, J.; Kristensen, M.; Refsum, H.‐E.; Öfsti, E.; Eriksson, S.; Syversen, S.

doi:10.1111/j.1600-0447.1992.tb03242.x

Cited by 258Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesDementia and Cognitive Impairment Research

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A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia

Nyth, A. L., Gottfries, C. G., Lyby, K., Smedegaard‐Andersen, L., Gylding‐Sabroe, J., Kristensen, M., Refsum, H.‐E., Öfsti, E., Eriksson, S., Syversen, S.·1992·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.1992.tb03242.x

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Abstract

A total of 149 patients in 7 centers in Denmark, Norway and Sweden entered a 6‐week double‐blind trial intended to assess the antidepressant effect and safety of citalopram vs placebo in depressed elderly patients (65 years of age or older) who might also suffer from somatic disorders and/or senile dementia. Results of ratings on the Hamilton Rating Scale for Depression, the Montgomery‐Åsberg Depression Rating Scale and the Clinical Global Impression Scale provided consistent evidence that the citalopram‐treated patients improved more than the placebo‐treated patients. Results of ratings on the Gottfries‐Bråne‐Steen dementia rating scale indicated that both cognitive and emotional functioning improved significantly more in the citalopram‐treated subgroup of patients with dementia than in the placebo‐treated subgroup.

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Authors: Nyth, A. L., Gottfries, C. G., Lyby, K., Smedegaard‐Andersen, L., Gylding‐Sabroe, J., Kristensen, M., Refsum, H. ‐., Öfsti, E., Eriksson, S., & Syversen, S.
Affiliations: University of Gothenburg (SE)
Lundbeck (Denmark) (DK)
Drammen Hospital (NO)
Umeå University (SE)
Ryhov Hospital Jönköping (SE)
Corresponding author: Nyth, A. L.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 1992-08
Volume: 86
Issue: 2
Pages: 138-145
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1111/j.1600-0447.1992.tb03242.x
OpenAlex: W2133710857
Cited by: 258
References: 3
Citations by year: 2026: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 4 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 6
FWCI: 6.93
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5500 d)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: citalopram, depression, elderly patients, dementia, antidepressant efficacy, antidepressant safety, cognitive function, emotional functioning, somatic diseases, placebo comparison
MeSH terms: Aged, Cognition, Dementia, Depressive Disorder, Double-Blind Method, Humans, Placebos, Citalopram

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A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia

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