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Cited by 1,144Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHistorical and Modern Theater Studies

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Mental and Behavioral Disturbances in Dementia: Findings From the Cache County Study on Memory in Aging

Lyketsos, Constantine G., Steinberg, Martin, Tschanz, JoAnn T., Norton, Maria C., Steffens, David C., Breitner, John C.S.·2000·American Journal of Psychiatry
DOI 10.1176/appi.ajp.157.5.708
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Abstract

Objective The authors report findings from a study of 5,092 community residents who constituted 90% of the elderly resident population of Cache County, Utah. Method The 5,092 participants, who were 65 years old or older, were screened for dementia. Based on the results of this screen, 1,002 participants (329 with dementia and 673 without dementia) underwent comprehensive neuropsychiatric examinations and were rated on the Neuropsychiatric Inventory, a widely used method for ascertainment and classification of dementia-associated mental and behavioral disturbances. Results Of the 329 participants with dementia, 214 (65%) had Alzheimer's disease, 62 (19%) had vascular dementia, and 53 (16%) had another DSM-IV dementia diagnosis; 201 (61%) had exhibited one or more mental or behavioral disturbances in the past month. Apathy (27%), depression (24%), and agitation/aggression (24%) were the most common in participants with dementia. These disturbances were almost four times more common in participants with dementia than in those without. Only modest differences were observed in the prevalence of mental or behavioral disturbances in different types of dementia or at different stages of illness: participants with Alzheimer's disease were more likely to have delusions and less likely to have depression. Agitation/aggression and aberrant motor behavior were more common in participants with advanced dementia. Conclusions On the basis of their findings in this large community population…

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  • Agitation is common, persistent, difficult to treat, costly, and associated with severe adverse consequences for patients and caregivers.

    “Agitation is common, persistent, difficult to treat, costly, and associated with severe adverse consequences for patients and caregivers1–5.”

    From Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial (2014) · cites this paper as [3]

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Metadata

Authors
Lyketsos, C. G., Steinberg, M., Tschanz, J. T., Norton, M. C., Steffens, D. C., & Breitner, J. C. S.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2000-05-01
Volume
157
Issue
5
Pages
708-714
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.157.5.708
OpenAlex
W2122813545
Cited by
1,144
References
2
Citations by year
2026: 11 · 2025: 25 · 2024: 29 · 2023: 23 · 2022: 36 · 2021: 45 · 2020: 37 · 2019: 47 · 2018: 44 · 2017: 42 · 2016: 56 · 2015: 57 · 2014: 51 · 2013: 71 · 2012: 62
FWCI
20.38
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Commons - USU (Utah State University) (submittedVersion)
Funders
  • National Institute on Aging (R01AG011380)
  • National Institute of Mental Health (R01MH056511)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
dementia, neuropsychiatric symptoms, behavioral problems, Alzheimer's disease, vascular dementia, apathy, depression, agitation, aggression, delusions, aberrant motor behavior, dementia severity, older adults
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Mental Disorders, Delusions, Dementia, Depressive Disorder, Female, Humans, Male, Psychiatric Status Rating Scales, Sampling Studies, Severity of Illness Index, Utah, Dementia, Vascular, Geriatric Assessment, Comorbidity, Prevalence

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