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Cited by 274Stress Responses and CortisolMemory and Neural MechanismsNeuropeptides and Animal Physiology

Local circuit regulation of paraventricular nucleus stress integration

Herman, James P., Tasker, Jeffrey G., Ziegler, Dana R., Cullinan, William E.·2002·Pharmacology Biochemistry and Behavior
DOI 10.1016/s0091-3057(01)00681-5
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Abstract

Limbic neurocircuits play a central role in regulation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Limbic influences on adrenocortical hormone secretion are mediated by transynaptic activation or inhibition of hypophysiotrophic neurons in the medial parvocellular paraventricular nucleus (PVN). Projections from the ventral subiculum, prefrontal cortex, medial amygdala, lateral septum, paraventricular thalamus and suprachiasmatic nucleus (SN) terminate in the immediate surround of the PVN, an area heavily populated by GABAergic interneurons. As such, these regions are positioned to modulate paraventricular output via excitation or inhibition of interneuronal projections into the PVN. In addition, the same limbic and diencephalic regions have projections to local PVN-projecting hypothalamic and basal telencephalic nuclei, including the dorsomedial and medial preoptic nuclei and the bed nucleus of the stria terminalis. These regions are involved in both inhibitory and excitatory regulation of the stress axis, indicating that they contain heterogeneous neuronal populations whose relative impact on the PVN is determined by the nature of afferent stimuli. Thus, limbic modulation of the pituitary-adrenocortical system appears to be a multisynaptic process integrated at the level of local PVN-projecting neurocircuits. Local circuits are likely the primary integrators of anticipatory stress responses, and may indeed be the focus of HPA dysfunction seen with aging or affective disease.

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Crossref · 10.1016/s0091-3057(01)00681-5

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  • There are no direct hippocampal, prefrontal, or amygdalar connections to the PVN; feedback from these regions is instead relayed via the BNST, lateral septum, and ventromedial hypothalamus, which are all predominantly GABAergic.

    “Because there are no direct hippocampal, prefrontal, or amygdalar connections to the PVN, feedback from these regions are instead relayed via the BNST, lateral septum, and ventromedial hypothalamus (VMH), which are all predominantly GABAergic (Herman et al., 2002(Herman et al., , 2004)).”

    From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Herman et al., 2002

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Authors
Herman, J. P., Tasker, J. G., Ziegler, D. R., & Cullinan, W. E.
Affiliations
  • University of Cincinnati (US)
  • Tulane University (US)
  • Marquette University (US)
Corresponding author
Herman, James P.
ORCID
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2002-03
Volume
71
Issue
3
Pages
457-468
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/s0091-3057(01)00681-5
OpenAlex
W1265796269
Cited by
274
References
103
Citations by year
2026: 10 · 2025: 10 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 12 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 4 · 2016: 10 · 2015: 13 · 2014: 13 · 2013: 15 · 2012: 9
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ns031187-05, 5r03mh060819-03)
  • National Institute of Mental Health (R01 MH56577, MH 60819, R01MH049698, R01 MH11980, R01 MH49698)
  • National Institute of Neurological Disorders and Stroke (NS31187)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
paraventricular nucleus, hypothalamic-pituitary-adrenal axis, stress response, GABAergic interneurons, limbic system, ventral subiculum, medial amygdala, suprachiasmatic nucleus, bed nucleus of the stria terminalis, dorsomedial hypothalamus, medial preoptic nucleus, anticipatory stress, aging, mood disorders
MeSH terms
Animals, gamma-Aminobutyric Acid, Humans, Nerve Net, Neural Pathways, Paraventricular Hypothalamic Nucleus, Stress, Physiological, Glutamic Acid

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