Amygdaloid Lesions: Differential Effect on Conditioned Stress and Immobilization-Induced Increases in Corticosterone and Renin Secretion
Abstract
The purpose of this study was to examine the contribution of the central nucleus of the amygdala to the expression of stress-induced increase in corticosterone and renin secretion. Neurons in the central amygdaloid nucleus of male rats were destroyed by bilateral injections of ibotenic acid, a neurotoxin that destroys cells but leaves fibers of passage intact. Two weeks later, the rats were subjected to immobilization for 20 min or to a conditioned stress (conditioned emotional response) procedure. Central amygdala lesions inhibited the increases in plasma corticosterone after exposure to both conditioned stress and immobilization. Lesions in the lateral amygdala had no effect on the corticosterone response to either stressor. Lesions in the central amygdala attenuated the renin response to conditioned stress but not to immobilization. In contrast, lateral amygdala lesions potentiated the renin response to immobilization but did not affect the renin response to conditioned stress. The results confirm previous studies that demonstrate the importance of the central amygdaloid nucleus in the expression of corticosterone to immobilization stress. In addition, the results show that neurons within the central amygdaloid nucleus are necessary for the full expression of conditioned stress-induced increase in corticosterone and renin secretion. The results are discussed with respect to the potential pathways that mediate stress-induced increases in corticosterone and renin secretion.
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Lesions to the central and corticomedial groups of the amygdala reduce ACTH and corticosterone secretion following stress.
“Lesions to these groups have been shown to reduce ACTH and corticosterone secretion following stress (66, 67).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [67]
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“Lesions to these groups have been shown to reduce ACTH and corticosterone secretion following stress (66, 67).”
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- Authors
- Van de Kar, L. D., Piechowski, R. A., Rittenhouse, P. A., & Gray, T. S.
- Affiliations
- Loyola University Chicago (US)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-07
- Volume
- 54
- Issue
- 2
- Pages
- 89-95
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2088083940
- Cited by
- 190
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 6
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- central amygdala, lateral amygdala, corticosterone, renin secretion, restraint stress, conditioned emotional response, ibotenic acid lesions
- MeSH terms
- Amygdala, Animals, Conditioning, Psychological, Corticosterone, Ibotenic Acid, Male, Rats, Inbred Strains, Renin, Restraint, Physical, Stress, Physiological, Rats
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