A Pilot Study with Very Low-Intensity, Intermediate-Frequency Electric Fields in Patients with Locally Advanced and/or Metastatic Solid Tumors
Open accessAbstract
BACKGROUND: The transmission of electric fields using insulated electrodes has demonstrated that very low-intensity, properly tuned, intermediate-frequency electric fields, termed tumor-treating fields (TTFields), selectively stunts tumor cell growth and is accompanied by a decrease in tumor angiogenesis. PATIENTS AND METHODS: This open, prospective pilot study was designed to evaluate the safety, tolerability, and efficacy profile of TTFields treatment in patients with locally advanced and/or metastatic solid tumors using the NovoTTF100A(TM) device. All 6 patients were heavily pre-treated with several lines of therapy; no additional standard treatment option was available to them. TTFields treatment using continuous NovoTTF-100A lasted a minimum of 14 days and was very well tolerated. RESULTS: No related serious adverse events occurred. Outcomes showed 1 partial response of a treated skin metastasis from a primary breast cancer, 3 cases where tumor growth was arrested during treatment, and 1 case of disease progression. One mesothelioma patient experienced lesion regression near TTFields with simultaneous tumor stability or progression in distal areas. CONCLUSION: Although the number of patients in this study is small, the lack of therapy toxicity and the efficacy observed in data gathered to date indicate the potential of TTFields as a new treatment modality for solid tumors, definitely warranting further investigation.
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TTFields have been demonstrated to be highly effective when applied to cell cultures, animal cancer models, and patients with locally advanced and/or metastatic solid tumors.
“A new physical cancer treatment modality termed Tumor Treating Fields, or TTFields, has recently been demonstrated to be highly effective when applied to cell cultures, animal cancer models, as well as to patients suffering from locally advanced and or metastatic solid tumors [1-3].”
From Chemotherapeutic treatment efficacy and sensitivity are increased by adjuvant alternating electric fields (TTFields) (2009) · cites this paper as [3]
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- Authors
- Salzberg, M., Kirson, E., Palti, Y., & Rochlitz, C.
- Affiliations
- University Hospital of Basel (CH)
- Novocure (United States) (US)
- Venue
- Onkologie
- Publisher
- S. Karger AG
- Published
- 2008
- Volume
- 31
- Issue
- 7
- Pages
- 362-365
- ISSN
- 0378-584X (ISSN-L)
- 1423-0240
- OpenAlex
- W1995972041
- Cited by
- 68
- References
- 6
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Onkologie (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- edoc (University of Basel)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- tumor treating fields, solid tumors, metastatic breast cancer, cutaneous metastasis, mesothelioma, tumor growth arrest, safety and tolerability, tumor angiogenesis
- MeSH terms
- Adult, Aged, Breast Neoplasms, Electricity, Electromagnetic Fields, Electric Stimulation Therapy, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasms, Pilot Projects, Skin Neoplasms, Treatment Outcome
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