Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine
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Intestinal permeability was estimated in healthy subjects after ingestion of aspirin (1.2+1.2 g), ibuprofen (400+400 mg) and indomethacin (75+50 mg) at midnight and an hour before starting a 51chromium labelled ethylenediaminetetraacetate absorption test. Intestinal permeability increased significantly from control levels following each drug and the effect was related to drug potency to inhibit cyclooxygenase. Intestinal permeability increased to a similar extent after oral and rectal administration of indomethacin showing that the effect is systemically mediated. Prostaglandin E2 decreased intestinal permeability significantly but failed to prevent the indomethacin induced increased intestinal permeability. These studies show that non-steroidal anti-inflammatory drugs disrupt the intestinal barrier function in man and suggest that the morphological correlates of the damage may reside at the level of the intercellular junctions.
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Many daily therapies and interventions in intensive care increase intestinal permeability, bacterial translocation, and bacterial virulence.
“Many daily therapies and interventions in intensive care increase intestinal permeability (eg, nonsteroidal anti-inflammatory drugs109 and parenteral feeding55,82), bacterial translocation (eg, antibiotics,65 corticosteroids,110 and opiates111), and bacterial virulence (eg, opiates19 and catecholamines22,51).”
From The microbiome and critical illness (2016) · cites this paper as [109]
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- Authors
- Bjarnason, I., Williams, P., Smethurst, P., Peters, T. J., & Levi, A. J.
- Affiliations
- Medical Research Council (GB)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1986-11
- Volume
- 27
- Issue
- 11
- Pages
- 1292-1297
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1434083
- OpenAlex
- W1985739635
- Cited by
- 267
- References
- 53
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- intestinal permeability, nonsteroidal anti-inflammatory drugs, aspirin, ibuprofen, indomethacin, prostaglandin E2, cyclooxygenase inhibition, intestinal barrier function, intercellular junctions
- MeSH terms
- Adult, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Humans, Ibuprofen, Indomethacin, Intestine, Small, Permeability, Prostaglandins E, Ranitidine, Dinoprostone
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