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Relationship between Plasma Profiles of Oxytocin and Adrenocorticotropic Hormone during Suckling or Breast Stimulation in Women
Open accessAbstract
Oxytocin (OT) administration has been shown to inhibit adrenocorticotropic hormone (ACTH)/cortisol secretion in several experimental conditions. In the present study, the plasma OT responses to suckling in 7 lactating women or to mechanical breast stimulation in 6 normally menstruating women (experimental tests) or to sham stimuli in the same subjects (control tests) were measured and correlated with the simultaneous changes in plasma ACTH/cortisol levels. All women showed similar basal levels of OT, ACTH and cortisol, which remained unmodified after sham stimulation. In contrast, both suckling and breast stimulation produced a significant increase in plasma OT levels and a significant decrease in plasma ACTH concentrations. When OT and ACTH data were considered together, a significant negative correlation was found between the OT increase and the simultaneous ACTH decline. Plasma cortisol levels were lower during suckling or breast stimulation than in control conditions. These data show an inverse relationship between plasma OT and ACTH levels during suckling and breast stimulation in humans, suggesting an inhibitory influence of OT on ACTH/cortisol secretion in a physiological condition.
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“On the other hand, plasma CORT decreases in human mothers (54), potentially through the suckling-induced OT (55) that can inhibit ACTH secretion (56).”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [55]
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“Altemus, Deuster, Galliven, Carter, and Gold (1995) found that lactating women showed suppressed HPA responses to stress, which is consistent with the animal literature showing reduced HPA activity in response to oxytocin (see also Chiodera et al., 1991; Lightman & Young, 1989).”
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“The observed negative correlation of both hormones indicates an inhibitory influence of OT on ACTH/ cortisol secretion under a certain physiological condition in humans (11, 107).”
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“…prolactin release and decreases basal plasma levels of adrenocorticotropin (ACTH) and cortisol, suggesting an inhibitory influence of both peptides on stress-responsive neurohormonal systems (Amico et al 1994; Chiodera et al 1991; Heinrichs et al 2001, 2002; Nissen et al 1996; Russell et al 2001).”
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“Furthermore, suckling decreases basal levels of ACTH and total plasma cortisol in lactating women (Chiodera et al., 1991; Amico et al., 1994).”
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Metadata
- Authors
- Chiodera, P., Salvarani, C., Bacchi-Modena, A., Spallanzani, R., Cigarini, C., Alboni, A., Gardini, E., & Coiro, V.
- Affiliations
- University of Parma (IT)
- ORCID
- Salvarani, C.
- Venue
- Hormone Research
- Publisher
- S. Karger AG
- Published
- 2008-12-02
- Volume
- 35
- Issue
- 3-4
- Pages
- 119-123
- ISSN
- 0301-0163 (ISSN-L)
- 1423-0046
- OpenAlex
- W2089029246
- Cited by
- 154
- References
- 0
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 1 · 2018: 19 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Hormone Research (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, ACTH, cortisol, suckling, breast stimulation, lactation, hypothalamic-pituitary-adrenal axis, negative feedback, plasma hormone levels, women
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Breast, Humans, Hydrocortisone, Infant, Newborn, Lactation, Oxytocin, Reference Values, Sucking Behavior, Postpartum Period
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