Actions of intravenous injections of AVP and oxytocin on plasma ACTH, GH, insulin and glucagon concentrations in goats
Abstract
This study was conducted to investigate the arginine-vasopressin (AVP)- and oxytocin-induced changes in plasma adrenocorticotropic hormone (ACTH), growth hormone (GH), insulin and glucagon levels and their metabolite concentrations in goats. In this study, five goats were intravenously injected with either AVP (0.3 nmol/kg body weight (BW)) or oxytocin (0.7 IU/kg BW). AVP injection significantly increased ACTH and GH secretions compared to controls, although insulin and glucagon concentrations were not altered. The incremental areas (ICAs) of the ACTH and GH concentrations were higher in the AVP group than in the saline group. Oxytocin injections increased insulin and glucagon secretions, while ACTH level was not altered. GH levels became elevated 30 min after the oxytocin injection. The ICAs of insulin and glucagon after oxytocin was injected were higher than those of the control. Results indicate that AVP is a potent stimulant of ACTH and GH secretions, while oxytocin uses different pathways to regulate insulin and glucagon secretions in goats.
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In dogs, intranasal oxytocin increases glucagon and insulin secretion, probably through peripheral actions, since intravenous oxytocin has similar effects in goats and dogs.
“Intranasal application in dogs increases glucagon and insulin secretion (37), and this is probably mediated peripherally as intravenous oxytocin has a similar effect in goats (38) and dogs (39).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [38]
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Intranasal Oxytocin: Myths and Delusions
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- Authors
- Roh, S., Koiwa, K., Sato, K., Ohtani, Y., Takahashi, T., & Katoh, K.
- Affiliations
- Laboratory of Animal Physiology Graduate School of Agricultural Science Tohoku University Sendai Japan
- Tohoku University (JP)
- Mito Research Center Meiji Feed Co., Ltd Ibaraki Japan
- Kitasato University (JP)
- Venue
- Animal Science Journal
- Publisher
- Wiley
- Published
- 2013-11-10
- Volume
- 85
- Issue
- 3
- Pages
- 286-292
- ISSN
- 1344-3941 (ISSN-L)
- 1740-0929
- OpenAlex
- W1935692682
- Cited by
- 7
- References
- 36
- Citations by year
- 2022: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Animal Science Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23658217)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- vasopressin, oxytocin, goats, ACTH, growth hormone, insulin, glucagon, plasma hormone levels, pituitary hormone secretion, intravenous injection
- MeSH terms
- Insulin Secretion, Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Glucagon, Goats, Injections, Intravenous, Insulin, Male, Oxytocin, Growth Hormone
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