15-Hydroxyeicosatetraenoic Acid (15-HETE) Specifically Inhibits LTB 4 -Induced Chemotaxis of Human Neutrophils

Ternowitz, Thomas; Fogh, Karsten; Kragballe, Knud

doi:10.1159/000210754

15-Hydroxyeicosatetraenoic Acid (15-HETE) Specifically Inhibits LTB 4 -Induced Chemotaxis of Human Neutrophils

15-Hydroxyeicosatetraenoic acid (15-HETE), a 15-lipoxygenase (15-LO) product of arachidonic acid has the potential to inhibit leukotriene formation. In the present study the effect of 15-HETE on leukotriene B 4 (LTB 4 )-induced polymorphonuclear leukocytes (PMN) and monocyte chemotaxis was invest…