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Lipid Peroxidation and Free Radical Scavengers in Alzheimer’s Disease
Abstract
Lipid peroxidation products and defenses against free radical damage were determined in serum of 55 patients with senile dementia of the Alzheimer type (SDAT) and compared with values in 24 age-matched healthy control subjects. The following parameters were evaluated: lipid-conjugated dienes and trienes, malondialdehyde, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in erythrocytes, vitamins E, C and A, zinc, selenium and copper, ceruloplasmin, transferrin and albumin. The results showed a statistically significant decrease in the levels of GSH-Px, vitamins E, C and A, zinc, transferrin and albumin in the SDAT group. On the other hand, most of the deficiencies concern the malnourished subgroup of the SDAT population (SOD, GSH-Px, vitamins E and C, selenium, zinc, transferrin and albumin). Such an alteration of free radical scavengers in the malnourished subgroup of the SDAT population could combine the radical and nutritional hypothesis advanced by some authors.
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Cited by
Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease
Marcus, D. L., Thomas, C., Rodriguez, C., Simberkoff, K., Tsai, J. S., Strafaci, J. A., & Freedman, M. L. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6750 · Cited by 513
The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease
Miranda, S., Opazo, C., Larrondo, L. F., Muñoz, F. J., Ruiz, F., Leighton, F., & Inestrosa, N. C. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00015-0 · Cited by 369
Biological variability of superoxide dismutase, glutathione peroxidase, and catalase in blood
Guemouri, L., Artur, Y., Herbeth, B., Jeandel, C., Cuny, G., & Siest, G. (1991) · Clinical Chemistry · doi:10.1093/clinchem/37.11.1932 · Cited by 363
Self-citationAssociation of vitamin E and C supplement use with cognitive function and dementia in elderly men
Masaki, K. H., Losonczy, K. G., Izmirlian, G., Foley, D. J., Ross, G. W., Petrovitch, H., Havlik, R., & White, L. R. (2000) · Neurology · doi:10.1212/wnl.54.6.1265 · Cited by 330
Zinc homeostasis and neurodegenerative disorders
Szewczyk, B. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00033 · Cited by 288
Metadata
- Authors
- Jeandel, C., Nicolas, M. B., Dubois, F., Nabet-Belleville, F., Penin, F., & Cuny, G.
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 1989
- Volume
- 35
- Issue
- 5-6
- Pages
- 275-282
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2016787732
- Cited by
- 250
- References
- 0
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jeandel, C., Nicolas, M. B., Dubois, F., Nabet-Belleville, F., Penin, F., & Cuny, G. (1989). Lipid Peroxidation and Free Radical Scavengers in Alzheimer’s Disease. Gerontology. https://doi.org/10.1159/000213037
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
