Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease
Open accessAbstract
The overall peroxidation activity in brain tissue by region from patients with Alzheimer's disease (AD) and age-matched controls was determined employing the thiobarbituric acid-reactive substances (TBARS) assay, a measure of lipid peroxidation, followed by a determination the activities of the antioxidant enzymes Cu/Zn superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), in the frontal, temporal, and cerebellar cortex of 10 AD and 9 control brains. The level of TBARS was elevated in all regions, with particular statistical significance in the temporal cortex when compared to age-matched controls. SOD activity was significantly decreased in AD frontal and AD temporal cortex, while catalase activity was significantly decreased in AD temporal cortex. There was no significant difference in GSH-Px activity found in any of the regions examined. This study supports the theory that in AD the brain is affected by increased oxidative stress which, when combined with a decrease in SOD activity, produces oxidative alterations, seen most significantly in temporal cortex in AD, where the pathophysiologic changes are most severe.
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Oxidative stress from mitochondrial dysfunction occurs in the early stage of AD.
“Oxidative stress from mitochondrial dysfunction occurs in the early stage of AD [7,8].”
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- Authors
- Marcus, D. L., Thomas, C., Rodriguez, C., Simberkoff, K., Tsai, J. S., Strafaci, J. A., & Freedman, M. L.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Marcus, David L.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 150
- Issue
- 1
- Pages
- 40-44
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1986783906
- Cited by
- 513
- References
- 32
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 10 · 2023: 30 · 2022: 22 · 2021: 24 · 2020: 15 · 2019: 21 · 2018: 21 · 2017: 12 · 2016: 28 · 2015: 24 · 2014: 23 · 2013: 23 · 2012: 24
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Experimental Neurology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (T35DK007421, T35-DK07421-12)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lipid peroxidation, oxidative stress, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, TBARS, temporal cortex, frontal cortex, cerebellum, brain tissue
- MeSH terms
- Aged, Alzheimer Disease, Antioxidants, Brain Chemistry, Cerebellum, Frontal Lobe, Glutathione Peroxidase, Humans, Nerve Tissue Proteins, Superoxide Dismutase, Temporal Lobe, Lipid Peroxidation, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Acatalasia
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