The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta
Abstract
Recent human studies have shown that a wide variety of prenatal stressors, from anxiety and partner relationship problems, to natural disasters, increase the risk for a diverse range of adverse neurodevelopmental outcomes in the child. These include impaired cognitive development and behavioral problems, autism and schizophrenia. However, many questions remain about the underlying processes. Much of the research, based on animal studies, has focussed on the maternal HPA axis, with mixed results. Maternal stress or anxiety during pregnancy has been found to be weakly associated with raised maternal cortisol, if at all. The placenta may be a more promising programming vector, because it controls fetal exposure to the maternal environment. Animal studies indicate that prenatal stress can affect the activity of the placental barrier enzyme 11-βHSD2, which metabolises cortisol. We review the evidence for a similar mechanism in humans and how maternal stress may cause other changes in the placenta which affect fetal neurodevelopment.
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Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
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Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years
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Self-citationPredictive adaptive responses and human evolution
Gluckman, P. D., Hanson, M. A., & Spencer, H. G. (2005) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2005.08.001 · Cited by 713
Prenatal exposure to maternal depression and cortisol influences infant temperament
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Self-citationStress During Pregnancy Affects General Intellectual and Language Functioning in Human Toddlers
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Maternal stress alters endocrine function of the feto-placental unit in rats
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Cited by
Dunkel Schetter, C., & Tanner, L. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283503680 · Cited by 1,268
Early Life Programming and Neurodevelopmental Disorders
Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961
Glucocorticoids, prenatal stress and the programming of disease
Harris, A., & Seckl, J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.007 · Cited by 871
Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done
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Self-citationFetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
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Metadata
- Authors
- O’Donnell, K., O’Connor, T. G., & Glover, V.
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 31
- Issue
- 4
- Pages
- 285-292
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W1978611831
- Cited by
- 510
- References
- 18
- FWCI
- 29.95
- Type
- journal article
- Language
- en
- Open access
- closed
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